The Potential Application of Chinese Medicine in Liver Diseases: A New Opportunity

Liver diseases have been a common challenge for people all over the world, which threatens the quality of life and safety of hundreds of millions of patients. China is a major country with liver diseases. Metabolic associated fatty liver disease, hepatitis B virus and alcoholic liver disease are the...

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Published inFrontiers in pharmacology Vol. 12; p. 771459
Main Authors Fu, Ke, Wang, Cheng, Ma, Cheng, Zhou, Honglin, Li, Yunxia
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 04.11.2021
Subjects
Chinese medicine
clinical trials
liver diseases
natural agents
Pharmacology
potential application
toxicity
toxicity
potential application
Chinese medicine
clinical trials
liver diseases
natural agents
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Abstract Liver diseases have been a common challenge for people all over the world, which threatens the quality of life and safety of hundreds of millions of patients. China is a major country with liver diseases. Metabolic associated fatty liver disease, hepatitis B virus and alcoholic liver disease are the three most common liver diseases in our country, and the number of patients with liver cancer is increasing. Therefore, finding effective drugs to treat liver disease has become an urgent task. Chinese medicine (CM) has the advantages of low cost, high safety, and various biological activities, which is an important factor for the prevention and treatment of liver diseases. This review systematically summarizes the potential of CM in the treatment of liver diseases, showing that CM can alleviate liver diseases by regulating lipid metabolism, bile acid metabolism, immune function, and gut microbiota, as well as exerting anti-liver injury, anti-oxidation, and anti-hepatitis virus effects. Among them, Keap1/Nrf2, TGF-β/SMADS, p38 MAPK, NF-κB/IκBα, NF-κB-NLRP3, PI3K/Akt, TLR4-MyD88-NF-κB and IL-6/STAT3 signaling pathways are mainly involved. In conclusion, CM is very likely to be a potential candidate for liver disease treatment based on modern phytochemistry, pharmacology, and genomeproteomics, which needs more clinical trials to further clarify its importance in the treatment of liver diseases.
AbstractList Liver diseases have been a common challenge for people all over the world, which threatens the quality of life and safety of hundreds of millions of patients. China is a major country with liver diseases. Metabolic associated fatty liver disease, hepatitis B virus and alcoholic liver disease are the three most common liver diseases in our country, and the number of patients with liver cancer is increasing. Therefore, finding effective drugs to treat liver disease has become an urgent task. Chinese medicine (CM) has the advantages of low cost, high safety, and various biological activities, which is an important factor for the prevention and treatment of liver diseases. This review systematically summarizes the potential of CM in the treatment of liver diseases, showing that CM can alleviate liver diseases by regulating lipid metabolism, bile acid metabolism, immune function, and gut microbiota, as well as exerting anti-liver injury, anti-oxidation, and anti-hepatitis virus effects. Among them, Keap1/Nrf2, TGF-β/SMADS, p38 MAPK, NF-κB/IκBα, NF-κB-NLRP3, PI3K/Akt, TLR4-MyD88-NF-κB and IL-6/STAT3 signaling pathways are mainly involved. In conclusion, CM is very likely to be a potential candidate for liver disease treatment based on modern phytochemistry, pharmacology, and genomeproteomics, which needs more clinical trials to further clarify its importance in the treatment of liver diseases.
Author Li, Yunxia
Wang, Cheng
Ma, Cheng
Fu, Ke
Zhou, Honglin
AuthorAffiliation State Key Laboratory of Southwestern Chinese Medicine Resources, Key Laboratory of Standardization for Chinese Herbal Medicine, Ministry of Education, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu , China
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Keywords toxicity
potential application
Chinese medicine
clinical trials
liver diseases
natural agents
Language English
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Notes This article was submitted to Gastrointestinal and Hepatic Pharmacology, a section of the journal Frontiers in Pharmacology
Edited by: Annabella Vitalone, Sapienza University of Rome, Italy
These authors have contributed equally to this work
Reviewed by: Luis Enrique Gomez-Quiroz, Autonomous Metropolitan University, Mexico
Maitane Asensio, University of Salamanca, Spain
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600187/
PMID 34803712
ParticipantIDs doaj_primary_oai_doaj_org_article_7d80f57d627a4d41ba9f18062976c7ca
pubmedcentral_primary_oai_pubmedcentral_nih_gov_8600187
crossref_primary_10_3389_fphar_2021_771459
pubmed_primary_34803712
PublicationCentury 2000
PublicationDate 2021-11-04
PublicationDateYYYYMMDD 2021-11-04
PublicationDate_xml – month: 11
  year: 2021
  text: 2021-11-04
  day: 04
PublicationDecade 2020
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
PublicationTitle Frontiers in pharmacology
PublicationTitleAlternate Front Pharmacol
PublicationYear 2021
Publisher Frontiers Media S.A
Publisher_xml – name: Frontiers Media S.A
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Snippet Liver diseases have been a common challenge for people all over the world, which threatens the quality of life and safety of hundreds of millions of patients....
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SubjectTerms Chinese medicine
clinical trials
liver diseases
natural agents
Pharmacology
potential application
toxicity
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Title The Potential Application of Chinese Medicine in Liver Diseases: A New Opportunity
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https://pubmed.ncbi.nlm.nih.gov/PMC8600187
https://doaj.org/article/7d80f57d627a4d41ba9f18062976c7ca
Volume 12
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