GABA in the central amygdaloid nucleus modulates the electrolyte excretion and hormonal responses to blood volume expansion in rats

• Published in: Brazilian journal of medical and biological research Vol. 42; no. 1; pp. 114 - 121
• Main Authors: Margatho, L O, Elias, L L K, Antunes-Rodrigues, J
• Format: Journal Article
• Language: English; Portuguese
• Published: Brazil Associação Brasileira de Divulgação Científica 01.01.2009
• Subjects: Amygdala - drug effects; Amygdala - physiology; Animals; Atrial Natriuretic Factor - blood; Atrial natriuretic peptide; Bicuculline - administration & dosage; Bicuculline - pharmacology; BIOLOGY; Blood Volume - drug effects; Blood Volume - physiology; Central amygdaloid nucleus; Diuresis - drug effects; Diuresis - physiology; GABA Agonists - administration & dosage; GABA Agonists - pharmacology; GABA Antagonists - administration & dosage; GABA Antagonists - pharmacology; Male; MEDICINE, RESEARCH & EXPERIMENTAL; Muscimol - administration & dosage; Muscimol - pharmacology; Natriuresis; Oxytocin; Oxytocin - blood; Rats; Rats, Wistar; Sodium - urine; Urine output; Central amygdaloid nucleus; Atrial natriuretic peptide; Natriuresis; Oxytocin; Urine output

We investigated the involvement of GABAergic mechanisms of the central amygdaloid nucleus (CeA) in unanesthetized rats subjected to acute isotonic or hypertonic blood volume expansion (BVE). Male Wistar rats bearing cannulas unilaterally implanted in the CeA were treated with vehicle, muscimol (0.2...