HLA-A11:01:01:01, HLA-C12:02:02:01-HLA-B52:01:02:02, Age and Sex Are Associated With Severity of Japanese COVID-19 With Respiratory Failure

• Published in: Frontiers in immunology Vol. 12; p. 658570
• Main Authors: Khor, Seik-Soon, Omae, Yosuke, Nishida, Nao, Sugiyama, Masaya, Kinoshita, Noriko, Suzuki, Tetsuya, Suzuki, Michiyo, Suzuki, Satoshi, Izumi, Shinyu, Hojo, Masayuki, Ohmagari, Norio, Mizokami, Masashi, Tokunaga, Katsushi
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 22.04.2021
• Subjects: Age Factors; allele; case-control analysis; Case-Control Studies; Comorbidity; COVID-19; COVID-19 - immunology; COVID-19 - pathology; Female; Gene Frequency - genetics; Genetic Association Studies; haplotype; Haplotypes - genetics; High-Throughput Nucleotide Sequencing; HLA; HLA-A11 Antigen - genetics; HLA-B52 Antigen - genetics; HLA-C Antigens - genetics; Humans; Immunology; Japan; Male; Middle Aged; Respiratory Insufficiency - genetics; Respiratory Insufficiency - virology; SARS-CoV-2 - immunology; Severity of Illness Index; Sex Factors; susceptibility genes; Japan; COVID-19; haplotype; HLA; susceptibility genes; allele; case-control analysis

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing coronavirus disease 2019 (COVID-19) was announced as an outbreak by the World Health Organization (WHO) in January 2020 and as a pandemic in March 2020. The majority of infected individuals have experienced no or only mi...