Diagnostic power of diffuse reflectance spectroscopy for targeted detection of breast lesions with microcalcifications

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 110; no. 2; pp. 471 - 476
• Main Authors: Soares, Jaqueline S., Barman, Ishan, Dingari, Narahara Chari, Volynskaya, Zoya, Liu, Wendy, Klein, Nina, Plecha, Donna, Dasari, Ramachandra R., Fitzmaurice, Maryann
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 08.01.2013; National Acad Sciences
• Subjects: Adult; Aged; Algorithms; Biological Sciences; Biopsies; Biopsy; Biopsy, Needle - methods; Breast cancer; Breast Neoplasms - diagnosis; Breast Neoplasms - pathology; Calcinosis - diagnosis; Calcinosis - pathology; Correlation analysis; Female; Humans; Lesions; Medical diagnosis; Middle Aged; Needle biopsies; Ohio; Optical reflection; Principal Component Analysis; Radiography; Raman scattering; Raman spectroscopy; Spectral reflectance; Spectroscopy; Spectrum Analysis - methods; Tissues; Ultraviolet reflection; Ohio

Microcalcifications geographically target the location of abnormalities within the breast and are of critical importance in breast cancer diagnosis. However, despite stereotactic guidance, core needle biopsy fails to retrieve microcalcifications in up to 15% of patients. Here, we introduce an approa...