Diagnostic power of diffuse reflectance spectroscopy for targeted detection of breast lesions with microcalcifications
Microcalcifications geographically target the location of abnormalities within the breast and are of critical importance in breast cancer diagnosis. However, despite stereotactic guidance, core needle biopsy fails to retrieve microcalcifications in up to 15% of patients. Here, we introduce an approa...
Saved in:
Published in | Proceedings of the National Academy of Sciences - PNAS Vol. 110; no. 2; pp. 471 - 476 |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
National Academy of Sciences
08.01.2013
National Acad Sciences |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Microcalcifications geographically target the location of abnormalities within the breast and are of critical importance in breast cancer diagnosis. However, despite stereotactic guidance, core needle biopsy fails to retrieve microcalcifications in up to 15% of patients. Here, we introduce an approach based on diffuse reflectance spectroscopy for detection of microcalcifications that focuses on variations in optical absorption stemming from the calcified clusters and the associated cross-linking molecules. In this study, diffuse reflectance spectra are acquired ex vivo from 203 sites in fresh biopsy tissue cores from 23 patients undergoing stereotactic breast needle biopsies. By correlating the spectra with the corresponding radiographic and histologie assessment, we have developed a support vector machine-derived decision algorithm, which shows high diagnostic power (positive predictive value and negative predictive value of 97% and 88%, respectively) for diagnosis of lesions with microcalcifications. We further show that these results are robust and not due to any spurious correlations. We attribute our findings to the presence of proteins (such as elastin), and desmosine and isodesmosine cross-linkers in the microcalcifications. It is important to note that the performance of the diffuse reflectance decision algorithm is comparable to one derived from the corresponding Raman spectra, and the considerably higher intensity of the reflectance signal enables the detection of the targeted lesions in a fraction of the spectral acquisition time. Our findings create a unique landscape for spectroscopic validation of breast core needle biopsy for detection of microcalcifications that can substantially improve the likelihood of an adequate, diagnostic biopsy in the first attempt. |
---|---|
AbstractList | Microcalcifications geographically target the location of abnormalities within the breast and are of critical importance in breast cancer diagnosis. However, despite stereotactic guidance, core needle biopsy fails to retrieve microcalcifications in up to 15% of patients. Here, we introduce an approach based on diffuse reflectance spectroscopy for detection of microcalcifications that focuses on variations in optical absorption stemming from the calcified clusters and the associated cross-linking molecules. In this study, diffuse reflectance spectra are acquired ex vivo from 203 sites in fresh biopsy tissue cores from 23 patients undergoing stereotactic breast needle biopsies. By correlating the spectra with the corresponding radiographic and histologic assessment, we have developed a support vector machine-derived decision algorithm, which shows high diagnostic power (positive predictive value and negative predictive value of 97% and 88%, respectively) for diagnosis of lesions with microcalcifications. We further show that these results are robust and not due to any spurious correlations. We attribute our findings to the presence of proteins (such as elastin), and desmosine and isodesmosine cross-linkers in the microcalcifications. It is important to note that the performance of the diffuse reflectance decision algorithm is comparable to one derived from the corresponding Raman spectra, and the considerably higher intensity of the reflectance signal enables the detection of the targeted lesions in a fraction of the spectral acquisition time. Our findings create a unique landscape for spectroscopic validation of breast core needle biopsy for detection of microcalcifications that can substantially improve the likelihood of an adequate, diagnostic biopsy in the first attempt. Microcalcifications geographically target the location of abnormalities within the breast and are of critical importance in breast cancer diagnosis. However, despite stereotactic guidance, core needle biopsy fails to retrieve microcalcifications in up to 15% of patients. Here, we introduce an approach based on diffuse reflectance spectroscopy for detection of microcalcifications that focuses on variations in optical absorption stemming from the calcified clusters and the associated cross-linking molecules. In this study, diffuse reflectance spectra are acquired ex vivo from 203 sites in fresh biopsy tissue cores from 23 patients undergoing stereotactic breast needle biopsies. By correlating the spectra with the corresponding radiographic and histologic assessment, we have developed a support vector machine-derived decision algorithm, which shows high diagnostic power (positive predictive value and negative predictive value of 97% and 88%, respectively) for diagnosis of lesions with microcalcifications. We further show that these results are robust and not due to any spurious correlations. We attribute our findings to the presence of proteins (such as elastin), and desmosine and isodesmosine cross-linkers in the microcalcifications. It is important to note that the performance of the diffuse reflectance decision algorithm is comparable to one derived from the corresponding Raman spectra, and the considerably higher intensity of the reflectance signal enables the detection of the targeted lesions in a fraction of the spectral acquisition time. Our findings create a unique landscape for spectroscopic validation of breast core needle biopsy for detection of microcalcifications that can substantially improve the likelihood of an adequate, diagnostic biopsy in the first attempt. [PUBLICATION ABSTRACT] Microcalcifications geographically target the location of abnormalities within the breast and are of critical importance in breast cancer diagnosis. However, despite stereotactic guidance, core needle biopsy fails to retrieve microcalcifications in up to 15% of patients. Here, we introduce an approach based on diffuse reflectance spectroscopy for detection of microcalcifications that focuses on variations in optical absorption stemming from the calcified clusters and the associated cross-linking molecules. In this study, diffuse reflectance spectra are acquired ex vivo from 203 sites in fresh biopsy tissue cores from 23 patients undergoing stereotactic breast needle biopsies. By correlating the spectra with the corresponding radiographic and histologie assessment, we have developed a support vector machine-derived decision algorithm, which shows high diagnostic power (positive predictive value and negative predictive value of 97% and 88%, respectively) for diagnosis of lesions with microcalcifications. We further show that these results are robust and not due to any spurious correlations. We attribute our findings to the presence of proteins (such as elastin), and desmosine and isodesmosine cross-linkers in the microcalcifications. It is important to note that the performance of the diffuse reflectance decision algorithm is comparable to one derived from the corresponding Raman spectra, and the considerably higher intensity of the reflectance signal enables the detection of the targeted lesions in a fraction of the spectral acquisition time. Our findings create a unique landscape for spectroscopic validation of breast core needle biopsy for detection of microcalcifications that can substantially improve the likelihood of an adequate, diagnostic biopsy in the first attempt. |
Author | Dasari, Ramachandra R. Liu, Wendy Dingari, Narahara Chari Soares, Jaqueline S. Klein, Nina Barman, Ishan Volynskaya, Zoya Fitzmaurice, Maryann Plecha, Donna |
Author_xml | – sequence: 1 givenname: Jaqueline S. surname: Soares fullname: Soares, Jaqueline S. – sequence: 2 givenname: Ishan surname: Barman fullname: Barman, Ishan – sequence: 3 givenname: Narahara Chari surname: Dingari fullname: Dingari, Narahara Chari – sequence: 4 givenname: Zoya surname: Volynskaya fullname: Volynskaya, Zoya – sequence: 5 givenname: Wendy surname: Liu fullname: Liu, Wendy – sequence: 6 givenname: Nina surname: Klein fullname: Klein, Nina – sequence: 7 givenname: Donna surname: Plecha fullname: Plecha, Donna – sequence: 8 givenname: Ramachandra R. surname: Dasari fullname: Dasari, Ramachandra R. – sequence: 9 givenname: Maryann surname: Fitzmaurice fullname: Fitzmaurice, Maryann |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23267090$$D View this record in MEDLINE/PubMed |
BookMark | eNpdkUtv1DAUhS1URKeFNSuQJTZs0l6_4mSDVJWnVIkNrC3Hj6lHmTjYTqv-exx1mAIb2_L57tG995yhkylODqHXBC4ISHY5TzpfEEoEl4wQeIY2BHrStLyHE7QBoLLpOOWn6CznHQD0ooMX6JQy2kroYYPuPga9nWIuweA53ruEo8c2eL9kh5PzozNFT8bhPNdXitnE-QH7mHDRaeuKs9jW05QQp7V0SE7ngkeX60fG96Hc4n0wKRo9muCD0SuZX6LnXo_ZvTrc5-jn508_rr82N9-_fLu-umkMb0VprGMD4yBp3xIAK-XQe80JGMK6wXsuu9YL0Q6W6KHjVZQGCGHWEtFb4Jydow-PvvMy7J01bipJj2pOYa_Tg4o6qH-VKdyqbbxTTHAhu64avD8YpPhrcbmofcjGjaOeXFyyIlQyJjomaUXf_Yfu4pKmOl6l2k4A7_u2UpePVN1JznXDx2YIqDVTtWaqnjKtFW__nuHI_wmxAm8OwFp5tKt-VHFJnvRdLjEdAU6FYB3h7DelYrVZ |
CitedBy_id | crossref_primary_10_1364_BOE_493179 crossref_primary_10_1039_c3an00245d crossref_primary_10_3390_diagnostics13091633 crossref_primary_10_3390_cancers14225715 crossref_primary_10_1007_s10103_015_1830_6 crossref_primary_10_1038_srep02822 crossref_primary_10_1140_epjti_s40485_015_0018_6 crossref_primary_10_1088_1612_202X_abafbf crossref_primary_10_1177_0967033518806637 crossref_primary_10_1364_AO_58_00A135 crossref_primary_10_4155_bio_13_126 crossref_primary_10_1364_AO_58_00A112 crossref_primary_10_1007_s10103_022_03524_0 crossref_primary_10_1016_j_bbadis_2018_08_022 crossref_primary_10_1021_ac500592y crossref_primary_10_1364_BOE_10_006096 crossref_primary_10_3390_diagnostics13030457 crossref_primary_10_1002_jbio_202000280 crossref_primary_10_1117_1_JBO_22_12_121609 crossref_primary_10_1016_j_saa_2024_124046 crossref_primary_10_1021_acs_analchem_1c00522 crossref_primary_10_1364_BOE_10_000961 crossref_primary_10_1364_BOE_505153 crossref_primary_10_1186_s12967_018_1747_5 crossref_primary_10_1002_jbio_202300001 crossref_primary_10_1016_j_jneumeth_2019_108466 crossref_primary_10_1063_1_5144483 crossref_primary_10_1080_00032719_2021_2017948 crossref_primary_10_1002_jbio_201500248 crossref_primary_10_1021_cbmi_3c00021 crossref_primary_10_1007_s40010_018_0519_1 crossref_primary_10_1038_srep41357 crossref_primary_10_1002_EXP_20230033 crossref_primary_10_1186_s12967_019_2083_0 crossref_primary_10_1021_ac503647x crossref_primary_10_1117_1_JBO_20_10_105002 crossref_primary_10_1186_1476_4598_12_48 crossref_primary_10_1038_s41598_020_79517_2 crossref_primary_10_1088_1361_6463_ac0c4c |
Cites_doi | 10.1117/1.429978 10.1039/b705029a 10.1118/1.596777 10.1002/lsm.1900100305 10.1366/12-06801 10.1146/annurev.physchem.47.1.555 10.1117/1.3247154 10.1364/AO.38.006628 10.1200/JCO.2007.14.3065 10.1158/0008-5472.CAN-08-3370 10.1016/0002-8703(92)90767-P 10.1117/1.2909672 10.1117/1.3656732 10.1148/radiol.2383041953 10.1093/bioinformatics/btg182 10.1117/1.2975962 10.1016/S1054-8807(01)00064-3 10.1007/978-1-4757-3061-6 10.3949/ccjm.75.Suppl_1.S2 10.1161/01.ATV.0000225699.36212.23 10.1007/BF02524348 10.1186/bcr1358 10.1016/0002-8703(89)90239-1 10.1073/pnas.071511098 10.1073/pnas.0501390102 10.1364/OE.15.006696 10.1158/0008-5472.CAN-07-6557 10.1158/0008-5472.CAN-05-2815 10.1364/BOE.2.002792 10.1021/ac203266a 10.1021/ac3011439 10.1201/b14001 10.1053/gast.2001.24842 10.1063/1.3117832 10.1088/0031-9155/35/9/010 |
ContentType | Journal Article |
Copyright | copyright © 1993-2008 National Academy of Sciences of the United States of America Copyright National Academy of Sciences Jan 8, 2013 |
Copyright_xml | – notice: copyright © 1993-2008 National Academy of Sciences of the United States of America – notice: Copyright National Academy of Sciences Jan 8, 2013 |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QG 7QL 7QP 7QR 7SN 7SS 7T5 7TK 7TM 7TO 7U9 8FD C1K FR3 H94 M7N P64 RC3 7X8 5PM |
DOI | 10.1073/pnas.1215473110 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database AIDS and Cancer Research Abstracts Algology Mycology and Protozoology Abstracts (Microbiology C) Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Virology and AIDS Abstracts Oncogenes and Growth Factors Abstracts Technology Research Database Nucleic Acids Abstracts Ecology Abstracts Neurosciences Abstracts Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management Entomology Abstracts Genetics Abstracts Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts Chemoreception Abstracts Immunology Abstracts Engineering Research Database Calcium & Calcified Tissue Abstracts MEDLINE - Academic |
DatabaseTitleList | Virology and AIDS Abstracts MEDLINE CrossRef |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Sciences (General) |
DocumentTitleAlternate | Reflectance spectra detect breast calcifications |
EISSN | 1091-6490 |
EndPage | 476 |
ExternalDocumentID | 2862147801 10_1073_pnas_1215473110 23267090 110_2_471 42553814 |
Genre | Comparative Study Clinical Trial Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural Feature |
GeographicLocations | Ohio |
GeographicLocations_xml | – name: Ohio |
GrantInformation_xml | – fundername: NCI NIH HHS grantid: R01 CA140288 – fundername: NCI NIH HHS grantid: R01-CA140288 – fundername: NCRR NIH HHS grantid: P41 RR002594 – fundername: NCRR NIH HHS grantid: P41-RR02594 – fundername: NIBIB NIH HHS grantid: P41 EB015871 |
GroupedDBID | --- -DZ -~X .55 0R~ 123 29P 2AX 2FS 2WC 4.4 53G 5RE 5VS 79B 85S AACGO AAFWJ AANCE ABBHK ABOCM ABPLY ABPPZ ABTLG ABXSQ ABZEH ACGOD ACIWK ACNCT ACPRK ADULT ADZLD AENEX AEUPB AEXZC AFFNX AFOSN AFRAH ALMA_UNASSIGNED_HOLDINGS AQVQM ASUFR BKOMP CS3 D0L DCCCD DIK DNJUQ DOOOF DU5 DWIUU E3Z EBS EJD F5P FRP GX1 HH5 HYE JAAYA JBMMH JENOY JHFFW JKQEH JLS JLXEF JPM JSG JSODD JST KQ8 L7B LU7 MVM N9A N~3 O9- OK1 PNE PQQKQ R.V RHF RHI RNA RNS RPM RXW SA0 SJN TAE TN5 UKR VQA W8F WH7 WOQ WOW X7M XSW Y6R YBH YKV YSK ZA5 ZCA ~02 ~KM - 02 0R 1AW 55 AAPBV ABFLS ABPTK ADACO AJYGW DZ F20 H13 KM PQEST X XHC ADACV CGR CUY CVF ECM EIF IPSME NPM AAYXX CITATION 7QG 7QL 7QP 7QR 7SN 7SS 7T5 7TK 7TM 7TO 7U9 8FD C1K FR3 H94 M7N P64 RC3 7X8 ADQXQ 5PM HTVGU P-O |
ID | FETCH-LOGICAL-c465t-de3b3407296100d77b9fa410c138bff4786f556bd1ab84b9f7c0113dd159d0443 |
IEDL.DBID | RPM |
ISSN | 0027-8424 |
IngestDate | Tue Sep 17 21:21:26 EDT 2024 Fri Aug 16 00:34:53 EDT 2024 Thu Oct 10 20:38:00 EDT 2024 Fri Aug 23 03:01:01 EDT 2024 Sat Sep 28 07:52:01 EDT 2024 Wed Nov 11 00:29:50 EST 2020 Fri Feb 02 07:04:29 EST 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 2 |
Language | English |
License | Freely available online through the PNAS open access option. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c465t-de3b3407296100d77b9fa410c138bff4786f556bd1ab84b9f7c0113dd159d0443 |
Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 Author contributions: J.S.S., I.B., N.C.D., Z.V., R.R.D., and M.F. designed research; J.S.S., I.B., N.C.D., Z.V., W.L., N.K., D.P., and M.F. performed research; J.S.S., I.B., and N.C.D. analyzed data; and J.S.S., I.B., N.C.D., and M.F. wrote the paper. 1J.S.S., I.B., and N.C.D. contributed equally to this work. 2Present address: Aperio Technologies, Inc., Vista, CA, 92081. Edited* by Mildred S. Dresselhaus, Massachusetts Institute of Technology, Cambridge, MA, and approved November 14, 2012 (received for review September 5, 2012) |
OpenAccessLink | https://www.pnas.org/content/pnas/110/2/471.full.pdf |
PMID | 23267090 |
PQID | 1268504996 |
PQPubID | 42026 |
PageCount | 6 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_3545788 proquest_journals_1268504996 pnas_primary_110_2_471 jstor_primary_42553814 pubmed_primary_23267090 proquest_miscellaneous_1273358372 crossref_primary_10_1073_pnas_1215473110 |
ProviderPackageCode | RNA PNE |
PublicationCentury | 2000 |
PublicationDate | 2013-01-08 |
PublicationDateYYYYMMDD | 2013-01-08 |
PublicationDate_xml | – month: 01 year: 2013 text: 2013-01-08 day: 08 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States – name: Washington |
PublicationTitle | Proceedings of the National Academy of Sciences - PNAS |
PublicationTitleAlternate | Proc Natl Acad Sci U S A |
PublicationYear | 2013 |
Publisher | National Academy of Sciences National Acad Sciences |
Publisher_xml | – name: National Academy of Sciences – name: National Acad Sciences |
References | 22025985 - Biomed Opt Express. 2011 Oct 1;2(10):2792-803 19546980 - Opt Express. 2007 May 28;15(11):6696-716 2816687 - Am Heart J. 1989 Nov;118(5 Pt 1):1028-38 11375944 - Gastroenterology. 2001 Jun;120(7):1620-9 23031693 - Appl Spectrosc. 2012 Oct;66(10):1091-120 22112122 - J Biomed Opt. 2011 Nov;16(11):116017 2236211 - Phys Med Biol. 1990 Sep;35(9):1317-34 19293184 - Cancer Res. 2009 Apr 1;69(7):2919-26 1518476 - Med Phys. 1992 Jul-Aug;19(4):879-88 11287650 - Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4420-5 16116095 - Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12371-6 18711192 - J Clin Oncol. 2008 Aug 20;26(24):4012-21 14699036 - Ann Surg Oncol. 2004 Jan;11(1):65-70 19021389 - J Biomed Opt. 2008 Sep-Oct;13(5):054009 17710265 - Analyst. 2007 Sep;132(9):899-905 16567483 - Radiology. 2006 Apr;239(1):61-70 18457191 - Cleve Clin J Med. 2008 Mar;75 Suppl 1:S2-9 10938775 - J Biomed Opt. 2000 Apr;5(2):119-30 1729827 - Am Heart J. 1992 Jan;123(1):208-16 12912828 - Bioinformatics. 2003 Aug 12;19(12):1484-91 18324198 - Appl Opt. 1999 Nov 1;38(31):6628-37 18465975 - J Biomed Opt. 2008 Mar-Apr;13(2):024012 16675721 - Arterioscler Thromb Vasc Biol. 2006 Jul;26(7):1594-600 16540686 - Cancer Res. 2006 Mar 15;66(6):3317-22 2589947 - Arch Pathol Lab Med. 1989 Dec;113(12):1367-9 19895125 - J Biomed Opt. 2009 Sep-Oct;14(5):054023 12235010 - Cancer Res. 2002 Sep 15;62(18):5375-80 18519705 - Cancer Res. 2008 Jun 1;68(11):4424-30 22324826 - Anal Chem. 2012 Mar 6;84(5):2474-82 16457705 - Breast Cancer Res. 2005;7(6):279-85 22746329 - Anal Chem. 2012 Aug 7;84(15):6715-22 8930102 - Annu Rev Phys Chem. 1996;47:555-606 11425600 - Cardiovasc Pathol. 2001 Mar-Apr;10(2):69-82 19405647 - Rev Sci Instrum. 2009 Apr;80(4):043103 2345474 - Lasers Surg Med. 1990;10(3):245-61 Eddaoudi F (e_1_3_3_4_2) 2011; 5 Jones JDC (e_1_3_3_40_2) 2003 e_1_3_3_17_2 American Cancer Society (e_1_3_3_1_2) 2012 e_1_3_3_16_2 e_1_3_3_19_2 e_1_3_3_38_2 e_1_3_3_18_2 e_1_3_3_39_2 e_1_3_3_13_2 e_1_3_3_36_2 e_1_3_3_12_2 e_1_3_3_37_2 e_1_3_3_15_2 e_1_3_3_34_2 e_1_3_3_14_2 e_1_3_3_35_2 e_1_3_3_32_2 e_1_3_3_33_2 e_1_3_3_11_2 e_1_3_3_30_2 e_1_3_3_10_2 e_1_3_3_31_2 Haka AS (e_1_3_3_23_2) 2002; 62 Radi MJ (e_1_3_3_5_2) 1989; 113 e_1_3_3_6_2 e_1_3_3_8_2 e_1_3_3_7_2 e_1_3_3_28_2 e_1_3_3_9_2 e_1_3_3_27_2 e_1_3_3_29_2 e_1_3_3_24_2 e_1_3_3_26_2 e_1_3_3_25_2 e_1_3_3_2_2 e_1_3_3_20_2 e_1_3_3_22_2 e_1_3_3_41_2 e_1_3_3_3_2 e_1_3_3_21_2 |
References_xml | – ident: e_1_3_3_30_2 doi: 10.1117/1.429978 – ident: e_1_3_3_16_2 doi: 10.1039/b705029a – ident: e_1_3_3_28_2 doi: 10.1118/1.596777 – ident: e_1_3_3_38_2 doi: 10.1002/lsm.1900100305 – ident: e_1_3_3_22_2 doi: 10.1366/12-06801 – ident: e_1_3_3_7_2 doi: 10.1146/annurev.physchem.47.1.555 – ident: e_1_3_3_21_2 doi: 10.1117/1.3247154 – ident: e_1_3_3_34_2 doi: 10.1364/AO.38.006628 – ident: e_1_3_3_9_2 doi: 10.1200/JCO.2007.14.3065 – ident: e_1_3_3_20_2 doi: 10.1158/0008-5472.CAN-08-3370 – ident: e_1_3_3_26_2 doi: 10.1016/0002-8703(92)90767-P – ident: e_1_3_3_18_2 doi: 10.1117/1.2909672 – ident: e_1_3_3_25_2 doi: 10.1117/1.3656732 – ident: e_1_3_3_6_2 doi: 10.1148/radiol.2383041953 – ident: e_1_3_3_33_2 doi: 10.1093/bioinformatics/btg182 – volume: 62 start-page: 5375 year: 2002 ident: e_1_3_3_23_2 article-title: Identifying microcalcifications in benign and malignant breast lesions by probing differences in their chemical composition using Raman spectroscopy publication-title: Cancer Res contributor: fullname: Haka AS – volume-title: Cancer Facts & Figures 2012 year: 2012 ident: e_1_3_3_1_2 contributor: fullname: American Cancer Society – volume: 113 start-page: 1367 year: 1989 ident: e_1_3_3_5_2 article-title: Calcium oxalate crystals in breast biopsies. An overlooked form of microcalcification associated with benign breast disease publication-title: Arch Pathol Lab Med contributor: fullname: Radi MJ – ident: e_1_3_3_17_2 doi: 10.1117/1.2975962 – ident: e_1_3_3_37_2 doi: 10.1016/S1054-8807(01)00064-3 – ident: e_1_3_3_39_2 doi: 10.1007/978-1-4757-3061-6 – ident: e_1_3_3_3_2 doi: 10.3949/ccjm.75.Suppl_1.S2 – ident: e_1_3_3_27_2 doi: 10.1161/01.ATV.0000225699.36212.23 – ident: e_1_3_3_11_2 doi: 10.1007/BF02524348 – ident: e_1_3_3_13_2 doi: 10.1186/bcr1358 – ident: e_1_3_3_2_2 – ident: e_1_3_3_36_2 doi: 10.1016/0002-8703(89)90239-1 – volume: 5 start-page: 381 year: 2011 ident: e_1_3_3_4_2 article-title: Microcalcifications detection in mammography images using texture coding publication-title: Appl Math Sci contributor: fullname: Eddaoudi F – ident: e_1_3_3_8_2 doi: 10.1073/pnas.071511098 – ident: e_1_3_3_12_2 doi: 10.1073/pnas.0501390102 – ident: e_1_3_3_15_2 doi: 10.1364/OE.15.006696 – ident: e_1_3_3_19_2 doi: 10.1158/0008-5472.CAN-07-6557 – ident: e_1_3_3_14_2 doi: 10.1158/0008-5472.CAN-05-2815 – ident: e_1_3_3_24_2 doi: 10.1364/BOE.2.002792 – ident: e_1_3_3_31_2 doi: 10.1021/ac203266a – ident: e_1_3_3_32_2 doi: 10.1021/ac3011439 – volume-title: Handbook of Laser Technology and Applications year: 2003 ident: e_1_3_3_40_2 contributor: fullname: Jones JDC – ident: e_1_3_3_35_2 doi: 10.1201/b14001 – ident: e_1_3_3_29_2 doi: 10.1053/gast.2001.24842 – ident: e_1_3_3_41_2 doi: 10.1063/1.3117832 – ident: e_1_3_3_10_2 doi: 10.1088/0031-9155/35/9/010 |
SSID | ssj0009580 |
Score | 2.3311255 |
Snippet | Microcalcifications geographically target the location of abnormalities within the breast and are of critical importance in breast cancer diagnosis. However,... |
SourceID | pubmedcentral proquest crossref pubmed pnas jstor |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 471 |
SubjectTerms | Adult Aged Algorithms Biological Sciences Biopsies Biopsy Biopsy, Needle - methods Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - pathology Calcinosis - diagnosis Calcinosis - pathology Correlation analysis Female Humans Lesions Medical diagnosis Middle Aged Needle biopsies Ohio Optical reflection Principal Component Analysis Radiography Raman scattering Raman spectroscopy Spectral reflectance Spectroscopy Spectrum Analysis - methods Tissues Ultraviolet reflection |
Title | Diagnostic power of diffuse reflectance spectroscopy for targeted detection of breast lesions with microcalcifications |
URI | https://www.jstor.org/stable/42553814 http://www.pnas.org/content/110/2/471.abstract https://www.ncbi.nlm.nih.gov/pubmed/23267090 https://www.proquest.com/docview/1268504996 https://search.proquest.com/docview/1273358372 https://pubmed.ncbi.nlm.nih.gov/PMC3545788 |
Volume | 110 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwEB4BJy5VoWwbXnKlHughbBLbsXNEUIQqUXEAiVtkx46K1M1GbBaJf8-M8yhUPXGMPLYiz3hmbH_-BuBban2mnU3jzFgRCyeyuBD4WWFswj61qULphOtf-dWd-Hkv7zdAjm9hAmi_sg-nzZ_FafPwO2Ar20U1H3Fi85vrc45hH7du803YVJyPW_SJaVf3704ydL8iEyOfj-LztjGrQKcgFMewR0TAmL2ohBzyq6jUAxOJ7RTl_5d5_gugfBWRLj_ChyGVZGf9L-_Ahm92YWdYrCt2MjBKf_8ETxc9oA4FWUtl0diyZlQaZb3yDH-Gju5J-yy8uyR-y2X7zDCdZT1Q3DvmfBdAWw11tYRk7xjOExkto7NctiBkHyo8YPz6Y8A9uLv8cXt-FQ8FF-JK5LKLneeWE2NagUlV4pSyRW1EmlQp17auhdJ5LWVuXWqsFtioKnQP3DnMiVwiBJ_BVrNs_BdgxARXaKVqQVerUhl08ErbhBtT2ESLCE7GCS_bnlejDPfhipc07eVfNUUwCwqZ5NDNoJtOcYxZEJ364wBZidE2gsNRZ-WwJGnAXEva4OURfJ2acTHRDYlp_HJNMmhPEvfsWQSfexVPo4-mEoF6o_xJgIi637ag_QbC7sFe99_d8wC2s1CGg46zD2Gre1z7I0yGOntMoUgehyXwArPtCoA |
link.rule.ids | 230,315,733,786,790,891,27955,27956,53825,53827 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB6VcoALUGAh0IKROJRDdpPYjp0jaqkW6FYcWtRbFMeOqNrNRmwWCX49M86DtuICx8hjK5bnZfvzNwBvY-MSbU0cJoURobAiCTOBnyXGJuxTFaUvnbA4Sedn4tO5PN8CObyF8aD90lxM66vltL745rGVzbKcDTix2ZfFAcewj1u32R24i_aayGGTPnLt6u7lSYIOWCRiYPRRfNbUxdoTKgjFMfARFTDmLyoil3wtLnXQROI7Rfm_5Z63IZTXYtLRQ_g6zKaDolxON62Zlr9uET3-83QfwYM-S2Xvu-Yd2HL1Y9jp_cCa7fdk1e-ewI_DDquHgqyhimtsVTGqurJZO4azpFsBUizmn3QSdeaq-ckwU2YdBt1ZZl3r8WA1dTUEkm8Z_hPZA6NjYrYk0CDqkocPdieMT-Hs6MPpwTzsazmEpUhlG1rHDScytgzztcgqZbKqEHFUxlybqhJKp5WUqbFxYbTARlWi5-HWYrplIyH4BLbrVe2eAyOSuUwrVQm6tZWqwNihtIl4UWQm0iKA_WEl86aj7Mj9VbviOa1n_mf9A5j4lR7l0IOhRsU4xsSLjv1xgCTHQB7A7qAMeW_tNGCqJe0d0wDejM1op3T5UtRutSEZxbnUXCUBPOt0Zxx90MEA1A2tGgWIA_xmC-qK5wLvdePFf_d8Dffmp4vj_PjjyeeXcD_x1T7o1HwXttvvG7eHOVdrXnkL-w11WiuY |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9QwEB1BkRAXoMBCoICROJRDNh92YueIWlblo1UPVKq4RHacqBVsNmKzSPDrmbGTsK049bjy2FrLbzxj--UNwNvE1KmyJglTbUQorEjDQuDPCmMT9ml05UonHJ_kR2fi03l2vlXqy5H2K3M5b38s5-3lheNWdssqGnli0enxAcewj0e3qLNNdBvuoM-mcjyoT3q7yn99kuImLFIxqvpIHnWtXjtRBSE5Bj-SA8YcRsa0LW_FJk9PJM1TtP9f_nmdRrkVlxYP4Ns4I09H-T7f9GZe_bkm9nijKT-E-0O2yt57k124VbePYHfYD9ZsfxCtfvcYfh16zh4aso4qr7FVw6j6ymZdM5wpvQ4QwJj7tJMkNFfdb4YZM_Nc9NoyW_eOF9ZSV0Nk-Z7h_yK_YHRdzJZEHkRMORqhv2l8AmeLD18PjsKhpkNYiTzrQ1tzw0mUrcC8LbZSmqLRIomrhCvTNEKqvMmy3NhEGyWwUVa4A3FrMe2ysRB8Bjvtqq2fASOxuUJJ2Qh6vc2kxhgilYm51oWJlQhgf1zNsvPSHaV7cpe8pDUt_2EggJlb7ckOdzJEVYJjzJzp1B8HSEsM6AHsjYAoB6-nAXOV0RkyD-DN1Iz-So8wuq1XG7KRnGeKyzSApx4_0-gjDgOQV5A1GZAW-NUWxIvTBB_w8fzGPV_D3dPDRfnl48nnF3AvdUU_6PJ8D3b6n5v6JaZevXnlnOwvzDwuGA |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Diagnostic+power+of+diffuse+reflectance+spectroscopy+for+targeted+detection+of+breast+lesions+with+microcalcifications&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+-+PNAS&rft.au=Soares%2C+Jaqueline+S.&rft.au=Barman%2C+Ishan&rft.au=Dingari%2C+Narahara+Chari&rft.au=Volynskaya%2C+Zoya&rft.date=2013-01-08&rft.pub=National+Academy+of+Sciences&rft.issn=0027-8424&rft.eissn=1091-6490&rft.volume=110&rft.issue=2&rft.spage=471&rft.epage=476&rft_id=info:doi/10.1073%2Fpnas.1215473110&rft_id=info%3Apmid%2F23267090&rft.externalDBID=PMC3545788 |
thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.pnas.org%2Fcontent%2F110%2F2.cover.gif |
thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.pnas.org%2Fcontent%2F110%2F2.cover.gif |