Enhancing Fatty Acids Oxidation via L-Carnitine Attenuates Obesity-Related Atrial Fibrillation and Structural Remodeling by Activating AMPK Signaling and Alleviating Cardiac Lipotoxicity

• Published in: Frontiers in pharmacology Vol. 12; p. 771940
• Main Authors: Zhang, Yudi, Fu, Yuping, Jiang, Tiannan, Liu, Binghua, Sun, Hongke, Zhang, Ying, Fan, Boyuan, Li, Xiaoli, Qin, Xinghua, Zheng, Qiangsun
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 26.11.2021
• Subjects: AMPK (5′-AMP activated kinase); atrial fibrillation; fatty acids oxidation; l-carnitine; lipotoxicity; obesity; Pharmacology; atrial fibrillation; AMPK (5′-AMP activated kinase); fatty acids oxidation; l-carnitine; obesity; lipotoxicity

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in clinical setting. Its pathogenesis was associated with metabolic disorder, especially defective fatty acids oxidation (FAO). However, whether promoting FAO could prevent AF occurrence and development remains elusive. In this...