Nonhematopoietic Nrf2 dominantly impedes adult progression of sickle cell anemia in mice

• Published in: JCI insight Vol. 1; no. 4
• Main Authors: Ghosh, Samit, Ihunnah, Chibueze A., Hazra, Rimi, Walker, Aisha L., Hansen, Jason M., Archer, David R., Owusu-Ansah, Amma T., Ofori-Acquah, Solomon F.
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 07.04.2016

The prevention of organ damage and early death in young adults is a major clinical concern in sickle cell disease (SCD). However, mechanisms that control adult progression of SCD during the transition from adolescence are poorly defined with no cognate prophylaxis. Here, we demonstrate in a longitud...