p53 genotypes and haplotypes associated with risk of breast cancer
Abstract Introduction : The biological significance of sequence variants in form of SNPs needs to be carefully evaluated, as conflicting associations with cancer predisposition have been reported. Haplotypes, the combination of closely linked alleles on a chromosome, play key roles in the study of t...
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Published in | Cancer detection and prevention Vol. 31; no. 3; pp. 207 - 213 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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England
Elsevier Ltd
01.01.2007
Elsevier Limited |
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Abstract | Abstract Introduction : The biological significance of sequence variants in form of SNPs needs to be carefully evaluated, as conflicting associations with cancer predisposition have been reported. Haplotypes, the combination of closely linked alleles on a chromosome, play key roles in the study of the genetic basis of disease. There is strong evidence that different polymorphisms within a single gene in cis position can interact to create a large effect on the observed phenotype. Several polymorphisms have been reported in the p53 gene. Some of these are within the coding region and may affect the function of the p53 protein, others are within introns or non-coding regions, and their significance is unclear. In this study, we investigated the association of specific p53 genotypes and haplotypes with risk of breast cancer. Methods : One hundred and fifteen patients with breast cancer and 63 healthy individuals were analyzed. DNA was isolated by salting out. The polymorphic sites were analyzed by PCR RFLP. Pearson's χ2 and Kolmogorof Simirnow tests were used for statistical analyses. Extended haplotype frequencies were estimated. Results : The distribution of the genotypes was similar for all three polymorphisms in the cases and the controls. Our estimated haplotype results indicate that the intron 3 (+16 bp) | exon 4 (Arg) diplotype and the intron 3 (+16 bp) | exon 4 (Arg) | intron 6 (G) haplotype combinations are overrepresented in the breast cancer group, suggesting that the intron 3 (+16 bp) | exon 4 (Arg) alleles may play a role in breast carcinogenesis. Conclusion : We conclude that two haplotypes harboring the intron 3 polymorphic (+16 bp) allele are associated with a higher risk of breast cancer in the Turkish population. |
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AbstractList | The biological significance of sequence variants in form of SNPs needs to be carefully evaluated, as conflicting associations with cancer predisposition have been reported. Haplotypes, the combination of closely linked alleles on a chromosome, play key roles in the study of the genetic basis of disease. There is strong evidence that different polymorphisms within a single gene in cis position can interact to create a large effect on the observed phenotype. Several polymorphisms have been reported in the p53 gene. Some of these are within the coding region and may affect the function of the p53 protein, others are within introns or non-coding regions, and their significance is unclear. In this study, we investigated the association of specific p53 genotypes and haplotypes with risk of breast cancer.
One hundred and fifteen patients with breast cancer and 63 healthy individuals were analyzed. DNA was isolated by salting out. The polymorphic sites were analyzed by PCR RFLP. Pearson's chi(2) and Kolmogorof Simirnow tests were used for statistical analyses. Extended haplotype frequencies were estimated.
The distribution of the genotypes was similar for all three polymorphisms in the cases and the controls. Our estimated haplotype results indicate that the intron 3 (+16bp)|exon 4 (Arg) diplotype and the intron 3 (+16bp)|exon 4 (Arg)|intron 6 (G) haplotype combinations are overrepresented in the breast cancer group, suggesting that the intron 3 (+16bp)|exon 4 (Arg) alleles may play a role in breast carcinogenesis.
We conclude that two haplotypes harboring the intron 3 polymorphic (+16bp) allele are associated with a higher risk of breast cancer in the Turkish population. Introduction: The biological significance of sequence variants in form of SNPs needs to be carefully evaluated, as conflicting associations with cancer predisposition have been reported. Haplotypes, the combination of closely linked alleles on a chromosome, play key roles in the study of the genetic basis of disease. There is strong evidence that different polymorphisms within a single gene incisposition can interact to create a large effect on the observed phenotype. Several polymorphisms have been reported in the p53 gene. Some of these are within the coding region and may affect the function of the p53 protein, others are within introns or non-coding regions, and their significance is unclear. In this study, we investigated the association of specific p53 genotypes and haplotypes with risk of breast cancer.Methods: One hundred and fifteen patients with breast cancer and 63 healthy individuals were analyzed. DNA was isolated by salting out. The polymorphic sites were analyzed by PCR RFLP. Pearson'sχ2and Kolmogorof Simirnow tests were used for statistical analyses. Extended haplotype frequencies were estimated.Results: The distribution of the genotypes was similar for all three polymorphisms in the cases and the controls. Our estimated haplotype results indicate that the intron 3 (+16bp)|exon 4 (Arg) diplotype and the intron 3 (+16bp)|exon 4 (Arg)|intron 6 (G) haplotype combinations are overrepresented in the breast cancer group, suggesting that the intron 3 (+16bp)|exon 4 (Arg) alleles may play a role in breast carcinogenesis.Conclusion: We conclude that two haplotypes harboring the intron 3 polymorphic (+16bp) allele are associated with a higher risk of breast cancer in the Turkish population. Abstract Introduction : The biological significance of sequence variants in form of SNPs needs to be carefully evaluated, as conflicting associations with cancer predisposition have been reported. Haplotypes, the combination of closely linked alleles on a chromosome, play key roles in the study of the genetic basis of disease. There is strong evidence that different polymorphisms within a single gene in cis position can interact to create a large effect on the observed phenotype. Several polymorphisms have been reported in the p53 gene. Some of these are within the coding region and may affect the function of the p53 protein, others are within introns or non-coding regions, and their significance is unclear. In this study, we investigated the association of specific p53 genotypes and haplotypes with risk of breast cancer. Methods : One hundred and fifteen patients with breast cancer and 63 healthy individuals were analyzed. DNA was isolated by salting out. The polymorphic sites were analyzed by PCR RFLP. Pearson's χ2 and Kolmogorof Simirnow tests were used for statistical analyses. Extended haplotype frequencies were estimated. Results : The distribution of the genotypes was similar for all three polymorphisms in the cases and the controls. Our estimated haplotype results indicate that the intron 3 (+16 bp) | exon 4 (Arg) diplotype and the intron 3 (+16 bp) | exon 4 (Arg) | intron 6 (G) haplotype combinations are overrepresented in the breast cancer group, suggesting that the intron 3 (+16 bp) | exon 4 (Arg) alleles may play a role in breast carcinogenesis. Conclusion : We conclude that two haplotypes harboring the intron 3 polymorphic (+16 bp) allele are associated with a higher risk of breast cancer in the Turkish population. Introduction: The biological significance of sequence variants in form of SNPs needs to be carefully evaluated, as conflicting associations with cancer predisposition have been reported. Haplotypes, the combination of closely linked alleles on a chromosome, play key roles in the study of the genetic basis of disease. There is strong evidence that different polymorphisms within a single gene in cis position can interact to create a large effect on the observed phenotype. Several polymorphisms have been reported in the p53 gene. Some of these are within the coding region and may affect the function of the p53 protein, others are within introns or non-coding regions, and their significance is unclear. In this study, we investigated the association of specific p53 genotypes and haplotypes with risk of breast cancer. Methods: One hundred and fifteen patients with breast cancer and 63 healthy individuals were analyzed. DNA was isolated by salting out. The polymorphic sites were analyzed by PCR RFLP. Pearson's χ 2 and Kolmogorof Simirnow tests were used for statistical analyses. Extended haplotype frequencies were estimated. Results: The distribution of the genotypes was similar for all three polymorphisms in the cases and the controls. Our estimated haplotype results indicate that the intron 3 (+16 bp) | exon 4 (Arg) diplotype and the intron 3 (+16 bp) | exon 4 (Arg) | intron 6 (G) haplotype combinations are overrepresented in the breast cancer group, suggesting that the intron 3 (+16 bp) | exon 4 (Arg) alleles may play a role in breast carcinogenesis. Conclusion: We conclude that two haplotypes harboring the intron 3 polymorphic (+16 bp) allele are associated with a higher risk of breast cancer in the Turkish population. Introduction: The biological significance of sequence variants in form of SNPs needs to be carefully evaluated, as conflicting associations with cancer predisposition have been reported. Haplotypes, the combination of closely linked alleles on a chromosome, play key roles in the study of the genetic sis of disease. There is strong evidence that different polymorphisms within a single gene in cis position can interact to create a large effect on the observed phenotype. Several polymorphisms have been reported in the p53 gene. Some of these are within the coding region and may affect the function of the p53 protein, others are within introns or non-coding regions, and their significance is unclear. In this study, we investigated the association of specific p53 genotypes and haplotypes with risk of breast cancer. Methods: One hundred and fifteen patients with breast cancer and 63 healthy individuals were analyzed. DNA was isolated by salting out. The polymorphic sites were analyzed by PCR RFLP. Pearson's [chi] super(2) and Kolmogorof Simirnow tests were used for statistical analyses. Extended haplotype frequencies were estimated. Results: The distribution of the genotypes was similar for all three polymorphisms in the cases and the controls. Our estimated haplotype results indicate that the intron 3 (+16 bp) exon 4 (Arg) diplotype and the intron 3 (+16 bp) exon 4 (Arg) intron 6 (G) haplotype combinations are overrepresented in the breast cancer group, suggesting that the intron 3 (+16 bp) exon 4 (Arg) alleles may play a role in breast carcinogenesis. Conclusion: We conclude that two haplotypes harboring the intron 3 polymorphic (+16 bp) allele are associated with a higher risk of breast cancer in the Turkish population. |
Author | Altinisik, Julide, MSc Demokan, Semra, PhD Buyru, Nur, PhD Dalay, Nejat, PhD |
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Cites_doi | 10.1006/gyno.1995.1244 10.1007/BF00210619 10.1089/dna.1995.14.983 10.1093/nar/25.1.151 10.1002/humu.20283 10.1093/carcin/16.9.2205 10.1159/000154325 10.1158/1078-0432.CCR-05-0173 10.1002/ijc.11548 10.1093/nar/19.17.4799-a 10.1016/S0165-4608(01)00428-9 10.1093/carcin/16.7.1461 10.1093/carcin/17.6.1313 10.1016/0092-8674(92)90421-8 10.1002/mc.2940040103 10.1016/S0140-6736(95)90745-9 10.1128/MCB.19.2.1092 10.1002/1097-0215(20000920)89:5<458::AID-IJC10>3.0.CO;2-R 10.1038/sj.onc.1207305 10.1136/jcp.2004.019315 10.1038/sj.bjc.6600595 10.1186/bcr319 10.1093/nar/16.3.1215 10.1093/clinchem/39.3.549b 10.1093/nar/19.24.6969-a 10.1093/jnci/94.9.681 10.1093/carcin/16.9.2233 10.1128/MCB.14.12.7805 10.1016/S0027-5107(97)00169-3 10.1016/S0140-6736(95)91239-8 10.1007/BF00201559 |
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Keywords | Breast cancer risk Genotype combinations Haplotype frequencies Functional p53 polymorphisms Single nucleotide changes DNA repair p53 |
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References | Roy, Beaman, Balint, Reisman (bib3) 1994; 14 Tommiska, Eerola, Heinonen, Salonen, Kaare, Tallila (bib16) 2005; 11 Fan, Wu, Miller, Wain, Kelsey, Wiencke (bib35) 2000; 9 Hahn, Serth, Fislage, Wolfes, Allhoff, Jonas (bib6) 1993; 39 Birgander, Själander, Zhou, Fan, Beckman, Beckman (bib42) 1996; 46 Lozano, Levine (bib5) 1991; 4 Chumakov, Jenkins (bib10) 1991; 19 Hillebrandt, Streffer, Demidchik, Biko, Reiners (bib15) 1997; 381 Lazar, Hazard, Bertin, Janin, Bellet, Bressac (bib13) 1993; 8 Prosser, Candic (bib11) 1991; 19 Buyru, Tezol, Dalay (bib22) 2005; 25 Själander, Birgander, Hallmans, Cajander, Lenner, Athlin (bib24) 1996; 17 Marsh, Spurdle, Turner, Fereday, Thorne, Pupo (bib19) 2001; 3 Gemignani, Moreno, Landi, Moullan, Chabrier, Gutierrez-Enriquez (bib18) 2004; 23 Själander, Birgander, Athlin, Stenling, Rutegard, Beckman (bib26) 1995; 16 Weston, Pan, Ksiesk, Wallenstein, Berkowitz, Tartter (bib38) 1997; 6 Thomas, Kalita, Labrecque, Pim, Banks, Matlashewski (bib27) 1999; 19 Lehman, Haffty, Carbone, Bishop, Gumbs, Krishnan (bib31) 2000; 60 Biros, Kalina, Kohut, Bogyiova, Salagovic, Sulla (bib44) 2002; 51 Fiszer-Maliszewska, Kazanowska, Kusnierczyk, Manczak, Nicpieklo, Pachron-Zeman (bib17) 2003; 44 Lancester, Brownlee, Wiseman, Taylor (bib34) 1995; 346 Buyru, Tigli, Dalay (bib28) 2003; 10 Buller, Skilling, Kaliszewski, Niemann, Anderson (bib9) 1995; 58 Mitra, Misra, Singh, Panda, Roychoudhury (bib43) 2005; 58 Sayhan, Yazici, Budak, Bitisik, Dalay (bib21) 2001; 109 Miller, Dykes, Polesky (bib33) 1988; 16 Peller, Kopilova, Slutzki, Halevy, Kvitko, Rotter (bib8) 1995; 14 Hainaut, Soussi, Shomer, Hollstein, Greenblatt, Hovig (bib4) 1997; 25 Plesants, Hansen (bib14) 1994; 93 Birgander, Själander, Rannug, Alexandrie, Sundberg, Seidegard (bib25) 1995; 16 Pim, Banks (bib29) 2004; 108 Harris (bib1) 1991; 253 Osorio, Martinez-Delgado, Pollan, Cuadros, Urioste, Torrenteras (bib40) 2006; 27 Wang-Gohrke, Rebbeck, Bessenfelder, Krienberg, Runnebaum (bib41) 1998; 18 Vogelstein, Kinzler (bib2) 1992; 70 Runnebaum, Tong, Konig, Zhao, Korner, Atkinson (bib23) 1995; 345 Varley, McGown, Thorncraft, Kelsey, Birch (bib32) 2001; 29 Lee, Lee, Yang, Shi, Lee, Luh (bib36) 2000; 89 Ito, Seyama, Hayashi, Mizuno, Iwamoto, Tsuyama (bib7) 1994; 93 Jin, Wu, Roth, Amos, King, Branch (bib30) 1995; 16 Wu, Zhao, Amos, Shete, Makan, Hong (bib20) 2002; 94 Papadakis, Soulitzis, Spandidos (bib37) 2002; 87 Fiszer-Maliszewska, Bebenek, Gorski, Kazanowska, Kurzawski, Sikorska (bib39) 2002; Suppl 1 Runnebaum, Tong, Moebus, Heilman, Kreback, Kreinberg (bib12) 1994; 93 Buller (10.1016/j.cdp.2007.04.004_bib9) 1995; 58 Fiszer-Maliszewska (10.1016/j.cdp.2007.04.004_bib17) 2003; 44 Prosser (10.1016/j.cdp.2007.04.004_bib11) 1991; 19 Birgander (10.1016/j.cdp.2007.04.004_bib25) 1995; 16 Gemignani (10.1016/j.cdp.2007.04.004_bib18) 2004; 23 Weston (10.1016/j.cdp.2007.04.004_bib38) 1997; 6 Osorio (10.1016/j.cdp.2007.04.004_bib40) 2006; 27 Lazar (10.1016/j.cdp.2007.04.004_bib13) 1993; 8 Chumakov (10.1016/j.cdp.2007.04.004_bib10) 1991; 19 Lee (10.1016/j.cdp.2007.04.004_bib36) 2000; 89 Varley (10.1016/j.cdp.2007.04.004_bib32) 2001; 29 Runnebaum (10.1016/j.cdp.2007.04.004_bib12) 1994; 93 Mitra (10.1016/j.cdp.2007.04.004_bib43) 2005; 58 Sayhan (10.1016/j.cdp.2007.04.004_bib21) 2001; 109 Harris (10.1016/j.cdp.2007.04.004_bib1) 1991; 253 Lancester (10.1016/j.cdp.2007.04.004_bib34) 1995; 346 Wang-Gohrke (10.1016/j.cdp.2007.04.004_bib41) 1998; 18 Hainaut (10.1016/j.cdp.2007.04.004_bib4) 1997; 25 Buyru (10.1016/j.cdp.2007.04.004_bib28) 2003; 10 Wu (10.1016/j.cdp.2007.04.004_bib20) 2002; 94 Pim (10.1016/j.cdp.2007.04.004_bib29) 2004; 108 Vogelstein (10.1016/j.cdp.2007.04.004_bib2) 1992; 70 Papadakis (10.1016/j.cdp.2007.04.004_bib37) 2002; 87 Birgander (10.1016/j.cdp.2007.04.004_bib42) 1996; 46 Lozano (10.1016/j.cdp.2007.04.004_bib5) 1991; 4 Thomas (10.1016/j.cdp.2007.04.004_bib27) 1999; 19 Marsh (10.1016/j.cdp.2007.04.004_bib19) 2001; 3 Peller (10.1016/j.cdp.2007.04.004_bib8) 1995; 14 Hahn (10.1016/j.cdp.2007.04.004_bib6) 1993; 39 Jin (10.1016/j.cdp.2007.04.004_bib30) 1995; 16 Lehman (10.1016/j.cdp.2007.04.004_bib31) 2000; 60 Fiszer-Maliszewska (10.1016/j.cdp.2007.04.004_bib39) 2002; Suppl 1 Biros (10.1016/j.cdp.2007.04.004_bib44) 2002; 51 Hillebrandt (10.1016/j.cdp.2007.04.004_bib15) 1997; 381 Runnebaum (10.1016/j.cdp.2007.04.004_bib23) 1995; 345 Själander (10.1016/j.cdp.2007.04.004_bib24) 1996; 17 Miller (10.1016/j.cdp.2007.04.004_bib33) 1988; 16 Fan (10.1016/j.cdp.2007.04.004_bib35) 2000; 9 Tommiska (10.1016/j.cdp.2007.04.004_bib16) 2005; 11 Själander (10.1016/j.cdp.2007.04.004_bib26) 1995; 16 Buyru (10.1016/j.cdp.2007.04.004_bib22) 2005; 25 Roy (10.1016/j.cdp.2007.04.004_bib3) 1994; 14 Ito (10.1016/j.cdp.2007.04.004_bib7) 1994; 93 Plesants (10.1016/j.cdp.2007.04.004_bib14) 1994; 93 |
References_xml | – volume: 345 start-page: 994 year: 1995 ident: bib23 article-title: p53 based blood test for p53PIN3 and risk for sporadic ovarian cancer publication-title: Lancet contributor: fullname: Atkinson – volume: 109 start-page: 25 year: 2001 end-page: 34 ident: bib21 article-title: p53 codon 72 genotypes in colon cancer. Association with human papillomavirus infection publication-title: Res Com Mol Pathol Pharmacol contributor: fullname: Dalay – volume: 93 start-page: 620 year: 1994 end-page: 624 ident: bib12 article-title: Multiplex PCR screening detects small p53 deletions and insertions in human ovarian cancer cell lines publication-title: Hum Genet contributor: fullname: Kreinberg – volume: 44 start-page: 547 year: 2003 end-page: 552 ident: bib17 article-title: Is publication-title: J Appl Genet contributor: fullname: Pachron-Zeman – volume: Suppl 1 start-page: 26 year: 2002 ident: bib39 article-title: Screening for predisposing mutations in Polish families with Li-Fraumeni/Li-Fraumeni-like syndrome or with breast and ovarian cancer publication-title: Cancer Detect Prev contributor: fullname: Sikorska – volume: 70 start-page: 523 year: 1992 end-page: 526 ident: bib2 article-title: publication-title: Cell contributor: fullname: Kinzler – volume: 381 start-page: 201 year: 1997 end-page: 207 ident: bib15 article-title: Polymorphisms in the p53 gene in thyroid tumours and blood samples of children from areas in Belarus publication-title: Mutat Res contributor: fullname: Reiners – volume: 108 start-page: 196 year: 2004 end-page: 199 ident: bib29 article-title: p53 polymorphic variants at codon 72 exert different effects on cell cycle progression publication-title: Int J Cancer contributor: fullname: Banks – volume: 346 start-page: 182 year: 1995 ident: bib34 article-title: p53 poymorphism in ovarian and bladder cancer publication-title: Lancet contributor: fullname: Taylor – volume: 23 start-page: 1954 year: 2004 end-page: 1956 ident: bib18 article-title: TP53 polymorphism is associated with increased risk of colorectal cancer and with reduced levels of TP53 mRNA publication-title: Oncogene contributor: fullname: Gutierrez-Enriquez – volume: 25 start-page: 151 year: 1997 end-page: 157 ident: bib4 article-title: Database of publication-title: Nucleic Acids Res contributor: fullname: Hovig – volume: 94 start-page: 681 year: 2002 end-page: 690 ident: bib20 article-title: p53 genotypes and haplotypes associated with lung cancer susceptibility and ethnicity publication-title: J Natl Cancer Inst contributor: fullname: Hong – volume: 51 start-page: 59 year: 2002 end-page: 64 ident: bib44 article-title: Allelic and haplotype frequencies of the p53 polymorphisms in brain tumor patients publication-title: Physiol Res contributor: fullname: Sulla – volume: 10 start-page: 711 year: 2003 end-page: 714 ident: bib28 article-title: p53 codon 72 polymorphism in breast cancer publication-title: Oncol Rep contributor: fullname: Dalay – volume: 14 start-page: 983 year: 1995 end-page: 990 ident: bib8 article-title: A novel polymorphism in intron 6 of the human publication-title: DNA Cell Biol contributor: fullname: Rotter – volume: 17 start-page: 1313 year: 1996 end-page: 1316 ident: bib24 article-title: p53 polymorphisms and haplotypes in breast cancer publication-title: Carcinogenesis contributor: fullname: Athlin – volume: 87 start-page: 1013 year: 2002 end-page: 1018 ident: bib37 article-title: Association of p53 codon 72 polymorphism with advanced lung cancer: the Arg allele is preferentially retained in tumours arising in Arg/Pro germline heterozygotes publication-title: Br J Cancer contributor: fullname: Spandidos – volume: 60 start-page: 1062 year: 2000 end-page: 1069 ident: bib31 article-title: Elevated frequency and functional activity of a specific germ-line publication-title: Cancer Res contributor: fullname: Krishnan – volume: 16 start-page: 1461 year: 1995 end-page: 1464 ident: bib26 article-title: P53 germline haplotypes associated with increased risk for colorectal cancer publication-title: Carcinogenesis contributor: fullname: Beckman – volume: 39 start-page: 549 year: 1993 end-page: 550 ident: bib6 article-title: Polymerase chain reaction detection of a highly polymorphic VNTR segment in intron 1 of the human p53 gene publication-title: Clin Chem contributor: fullname: Jonas – volume: 16 start-page: 2233 year: 1995 end-page: 2236 ident: bib25 article-title: p53 poymorphisms and haplotypes in lung cancer publication-title: Carcinogenesis contributor: fullname: Seidegard – volume: 16 start-page: 2205 year: 1995 end-page: 2208 ident: bib30 article-title: Higher lung cancer risk for younger African-Americans with the Pro/Pro p53 genotype publication-title: Carcinogenesis contributor: fullname: Branch – volume: 89 start-page: 458 year: 2000 end-page: 464 ident: bib36 article-title: Genetic polymorphisms of p53 and GSTP1, but not NAT2, are associated with susceptibility to squamous-cell carcinoma of the esophagus publication-title: Int J Cancer contributor: fullname: Luh – volume: 93 start-page: 607 year: 1994 end-page: 608 ident: bib14 article-title: Identification of a polymorphism in intron 2 of the p53 gene publication-title: Hum Genet contributor: fullname: Hansen – volume: 11 start-page: 5098 year: 2005 end-page: 5103 ident: bib16 article-title: Breast cancer patients with p53 Pro 72 homozygous genotype have a poorer survival publication-title: Clin Cancer Res contributor: fullname: Tallila – volume: 19 start-page: 6969 year: 1991 ident: bib10 article-title: publication-title: Nucleic Acids Res contributor: fullname: Jenkins – volume: 29 start-page: 85 year: 2001 end-page: 87 ident: bib32 article-title: Significance of intron 6 sequence variations in the TP53 gene in Li-Fraumeni syndrome publication-title: Cancer Genet Cytogenet contributor: fullname: Birch – volume: 58 start-page: 26 year: 2005 end-page: 31 ident: bib43 article-title: Association of specific genotype and haplotype of p53 gene with cervical cancer in India publication-title: J Clin Pathol contributor: fullname: Roychoudhury – volume: 93 start-page: 222 year: 1994 ident: bib7 article-title: Hae III polymorphism in intron 1 of the human p53 gene publication-title: Hum Genet contributor: fullname: Tsuyama – volume: 3 start-page: 346 year: 2001 end-page: 349 ident: bib19 article-title: The intronic G13964C variant in publication-title: Breast Cancer Res contributor: fullname: Pupo – volume: 9 start-page: 1037 year: 2000 end-page: 1042 ident: bib35 article-title: The p53 codon 72 polymorphism and lung cancer risk publication-title: Cancer Epidemiol Biomarkers Prev contributor: fullname: Wiencke – volume: 46 start-page: 49 year: 1996 end-page: 54 ident: bib42 article-title: p53 polymorphisms and haplotypes in nasopharyngeal cancer publication-title: Hum Hered contributor: fullname: Beckman – volume: 19 start-page: 4799 year: 1991 ident: bib11 article-title: Biallelic Apa I polymorphism of the human p53 gene (TP53) publication-title: Nucleic Acids Res contributor: fullname: Candic – volume: 6 start-page: 105 year: 1997 end-page: 112 ident: bib38 article-title: p53 haplotype determination in breast cancer publication-title: Cancer Epidemiol Biomarkers Prev contributor: fullname: Tartter – volume: 16 start-page: 1215 year: 1988 ident: bib33 article-title: A simple salting out procedure for extracting DNA from human nucleated cells publication-title: Nucleic Acid Res contributor: fullname: Polesky – volume: 18 start-page: 2095 year: 1998 end-page: 2099 ident: bib41 article-title: p53 germline polymorphisms are associated with an increased risk for breast cancer in German women publication-title: Anticancer Res contributor: fullname: Runnebaum – volume: 4 start-page: 3 year: 1991 end-page: 9 ident: bib5 article-title: Tissue-specific expression of publication-title: Mol Carcinog contributor: fullname: Levine – volume: 27 start-page: 242 year: 2006 end-page: 248 ident: bib40 article-title: A haplotype containing the p53 polymorphisms Ins16bp and Arg72Pro modifies cancer risk in BRCA2 mutation carriers publication-title: Hum Mutat contributor: fullname: Torrenteras – volume: 19 start-page: 1092 year: 1999 end-page: 1100 ident: bib27 article-title: Two polymorphic variants of wild-type p53 differ biochemically and biologically publication-title: Mol Cell Biol contributor: fullname: Matlashewski – volume: 58 start-page: 368 year: 1995 end-page: 374 ident: bib9 article-title: Absence of significant germ line publication-title: Gynecol Oncol contributor: fullname: Anderson – volume: 25 start-page: 2767 year: 2005 end-page: 2770 ident: bib22 article-title: p53 intronic G13964C variant in colon cancer and its association with HPV publication-title: Anticancer Res contributor: fullname: Dalay – volume: 14 start-page: 7805 year: 1994 end-page: 7815 ident: bib3 article-title: Transactivation of the human publication-title: Mol Cell Biol contributor: fullname: Reisman – volume: 8 start-page: 1703 year: 1993 end-page: 1705 ident: bib13 article-title: Simple sequence repeat polymorphism within the p53 gene publication-title: Oncogene contributor: fullname: Bressac – volume: 253 start-page: 49 year: 1991 end-page: 53 ident: bib1 article-title: publication-title: Science contributor: fullname: Harris – volume: 58 start-page: 368 year: 1995 ident: 10.1016/j.cdp.2007.04.004_bib9 article-title: Absence of significant germ line p53 mutations in ovarian cancer patients publication-title: Gynecol Oncol doi: 10.1006/gyno.1995.1244 contributor: fullname: Buller – volume: 93 start-page: 222 year: 1994 ident: 10.1016/j.cdp.2007.04.004_bib7 article-title: Hae III polymorphism in intron 1 of the human p53 gene publication-title: Hum Genet doi: 10.1007/BF00210619 contributor: fullname: Ito – volume: 14 start-page: 983 year: 1995 ident: 10.1016/j.cdp.2007.04.004_bib8 article-title: A novel polymorphism in intron 6 of the human p53 gene: a possible association with cancer predisposition and susceptibility publication-title: DNA Cell Biol doi: 10.1089/dna.1995.14.983 contributor: fullname: Peller – volume: 25 start-page: 151 year: 1997 ident: 10.1016/j.cdp.2007.04.004_bib4 article-title: Database of p53 gene somatic mutations in human tumors cell lines: updated compliation and future prospects publication-title: Nucleic Acids Res doi: 10.1093/nar/25.1.151 contributor: fullname: Hainaut – volume: 27 start-page: 242 year: 2006 ident: 10.1016/j.cdp.2007.04.004_bib40 article-title: A haplotype containing the p53 polymorphisms Ins16bp and Arg72Pro modifies cancer risk in BRCA2 mutation carriers publication-title: Hum Mutat doi: 10.1002/humu.20283 contributor: fullname: Osorio – volume: 16 start-page: 2205 year: 1995 ident: 10.1016/j.cdp.2007.04.004_bib30 article-title: Higher lung cancer risk for younger African-Americans with the Pro/Pro p53 genotype publication-title: Carcinogenesis doi: 10.1093/carcin/16.9.2205 contributor: fullname: Jin – volume: 46 start-page: 49 year: 1996 ident: 10.1016/j.cdp.2007.04.004_bib42 article-title: p53 polymorphisms and haplotypes in nasopharyngeal cancer publication-title: Hum Hered doi: 10.1159/000154325 contributor: fullname: Birgander – volume: 93 start-page: 607 year: 1994 ident: 10.1016/j.cdp.2007.04.004_bib14 article-title: Identification of a polymorphism in intron 2 of the p53 gene publication-title: Hum Genet contributor: fullname: Plesants – volume: 11 start-page: 5098 year: 2005 ident: 10.1016/j.cdp.2007.04.004_bib16 article-title: Breast cancer patients with p53 Pro 72 homozygous genotype have a poorer survival publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-05-0173 contributor: fullname: Tommiska – volume: 44 start-page: 547 year: 2003 ident: 10.1016/j.cdp.2007.04.004_bib17 article-title: Is p53 intronic variant G13964C associated with predisposition to cancer? publication-title: J Appl Genet contributor: fullname: Fiszer-Maliszewska – volume: 108 start-page: 196 year: 2004 ident: 10.1016/j.cdp.2007.04.004_bib29 article-title: p53 polymorphic variants at codon 72 exert different effects on cell cycle progression publication-title: Int J Cancer doi: 10.1002/ijc.11548 contributor: fullname: Pim – volume: 19 start-page: 4799 year: 1991 ident: 10.1016/j.cdp.2007.04.004_bib11 article-title: Biallelic Apa I polymorphism of the human p53 gene (TP53) publication-title: Nucleic Acids Res doi: 10.1093/nar/19.17.4799-a contributor: fullname: Prosser – volume: 25 start-page: 2767 year: 2005 ident: 10.1016/j.cdp.2007.04.004_bib22 article-title: p53 intronic G13964C variant in colon cancer and its association with HPV publication-title: Anticancer Res contributor: fullname: Buyru – volume: 60 start-page: 1062 year: 2000 ident: 10.1016/j.cdp.2007.04.004_bib31 article-title: Elevated frequency and functional activity of a specific germ-line p53 intron mutation in familial breast cancer publication-title: Cancer Res contributor: fullname: Lehman – volume: 29 start-page: 85 year: 2001 ident: 10.1016/j.cdp.2007.04.004_bib32 article-title: Significance of intron 6 sequence variations in the TP53 gene in Li-Fraumeni syndrome publication-title: Cancer Genet Cytogenet doi: 10.1016/S0165-4608(01)00428-9 contributor: fullname: Varley – volume: 10 start-page: 711 year: 2003 ident: 10.1016/j.cdp.2007.04.004_bib28 article-title: p53 codon 72 polymorphism in breast cancer publication-title: Oncol Rep contributor: fullname: Buyru – volume: 9 start-page: 1037 year: 2000 ident: 10.1016/j.cdp.2007.04.004_bib35 article-title: The p53 codon 72 polymorphism and lung cancer risk publication-title: Cancer Epidemiol Biomarkers Prev contributor: fullname: Fan – volume: 16 start-page: 1461 year: 1995 ident: 10.1016/j.cdp.2007.04.004_bib26 article-title: P53 germline haplotypes associated with increased risk for colorectal cancer publication-title: Carcinogenesis doi: 10.1093/carcin/16.7.1461 contributor: fullname: Själander – volume: 109 start-page: 25 year: 2001 ident: 10.1016/j.cdp.2007.04.004_bib21 article-title: p53 codon 72 genotypes in colon cancer. Association with human papillomavirus infection publication-title: Res Com Mol Pathol Pharmacol contributor: fullname: Sayhan – volume: 17 start-page: 1313 year: 1996 ident: 10.1016/j.cdp.2007.04.004_bib24 article-title: p53 polymorphisms and haplotypes in breast cancer publication-title: Carcinogenesis doi: 10.1093/carcin/17.6.1313 contributor: fullname: Själander – volume: 18 start-page: 2095 year: 1998 ident: 10.1016/j.cdp.2007.04.004_bib41 article-title: p53 germline polymorphisms are associated with an increased risk for breast cancer in German women publication-title: Anticancer Res contributor: fullname: Wang-Gohrke – volume: 70 start-page: 523 year: 1992 ident: 10.1016/j.cdp.2007.04.004_bib2 article-title: p53 function and dysfunction publication-title: Cell doi: 10.1016/0092-8674(92)90421-8 contributor: fullname: Vogelstein – volume: 6 start-page: 105 year: 1997 ident: 10.1016/j.cdp.2007.04.004_bib38 article-title: p53 haplotype determination in breast cancer publication-title: Cancer Epidemiol Biomarkers Prev contributor: fullname: Weston – volume: 51 start-page: 59 year: 2002 ident: 10.1016/j.cdp.2007.04.004_bib44 article-title: Allelic and haplotype frequencies of the p53 polymorphisms in brain tumor patients publication-title: Physiol Res contributor: fullname: Biros – volume: 4 start-page: 3 year: 1991 ident: 10.1016/j.cdp.2007.04.004_bib5 article-title: Tissue-specific expression of p53 in transgenic mice is regulated by intron sequences publication-title: Mol Carcinog doi: 10.1002/mc.2940040103 contributor: fullname: Lozano – volume: 345 start-page: 994 year: 1995 ident: 10.1016/j.cdp.2007.04.004_bib23 article-title: p53 based blood test for p53PIN3 and risk for sporadic ovarian cancer publication-title: Lancet doi: 10.1016/S0140-6736(95)90745-9 contributor: fullname: Runnebaum – volume: 19 start-page: 1092 year: 1999 ident: 10.1016/j.cdp.2007.04.004_bib27 article-title: Two polymorphic variants of wild-type p53 differ biochemically and biologically publication-title: Mol Cell Biol doi: 10.1128/MCB.19.2.1092 contributor: fullname: Thomas – volume: 8 start-page: 1703 year: 1993 ident: 10.1016/j.cdp.2007.04.004_bib13 article-title: Simple sequence repeat polymorphism within the p53 gene publication-title: Oncogene contributor: fullname: Lazar – volume: 89 start-page: 458 year: 2000 ident: 10.1016/j.cdp.2007.04.004_bib36 article-title: Genetic polymorphisms of p53 and GSTP1, but not NAT2, are associated with susceptibility to squamous-cell carcinoma of the esophagus publication-title: Int J Cancer doi: 10.1002/1097-0215(20000920)89:5<458::AID-IJC10>3.0.CO;2-R contributor: fullname: Lee – volume: 253 start-page: 49 year: 1991 ident: 10.1016/j.cdp.2007.04.004_bib1 article-title: p53: at the crossroads of molecular carcinogenesis and risk assessment publication-title: Science contributor: fullname: Harris – volume: 23 start-page: 1954 year: 2004 ident: 10.1016/j.cdp.2007.04.004_bib18 article-title: TP53 polymorphism is associated with increased risk of colorectal cancer and with reduced levels of TP53 mRNA publication-title: Oncogene doi: 10.1038/sj.onc.1207305 contributor: fullname: Gemignani – volume: 58 start-page: 26 year: 2005 ident: 10.1016/j.cdp.2007.04.004_bib43 article-title: Association of specific genotype and haplotype of p53 gene with cervical cancer in India publication-title: J Clin Pathol doi: 10.1136/jcp.2004.019315 contributor: fullname: Mitra – volume: 87 start-page: 1013 year: 2002 ident: 10.1016/j.cdp.2007.04.004_bib37 article-title: Association of p53 codon 72 polymorphism with advanced lung cancer: the Arg allele is preferentially retained in tumours arising in Arg/Pro germline heterozygotes publication-title: Br J Cancer doi: 10.1038/sj.bjc.6600595 contributor: fullname: Papadakis – volume: 3 start-page: 346 year: 2001 ident: 10.1016/j.cdp.2007.04.004_bib19 article-title: The intronic G13964C variant in p53 is not a high risk mutation in familial breast cancer in Australia publication-title: Breast Cancer Res doi: 10.1186/bcr319 contributor: fullname: Marsh – volume: 16 start-page: 1215 year: 1988 ident: 10.1016/j.cdp.2007.04.004_bib33 article-title: A simple salting out procedure for extracting DNA from human nucleated cells publication-title: Nucleic Acid Res doi: 10.1093/nar/16.3.1215 contributor: fullname: Miller – volume: 39 start-page: 549 year: 1993 ident: 10.1016/j.cdp.2007.04.004_bib6 article-title: Polymerase chain reaction detection of a highly polymorphic VNTR segment in intron 1 of the human p53 gene publication-title: Clin Chem doi: 10.1093/clinchem/39.3.549b contributor: fullname: Hahn – volume: 19 start-page: 6969 year: 1991 ident: 10.1016/j.cdp.2007.04.004_bib10 article-title: BstNI/NciI polymorphism of the human p53 gene (TP53) publication-title: Nucleic Acids Res doi: 10.1093/nar/19.24.6969-a contributor: fullname: Chumakov – volume: 94 start-page: 681 year: 2002 ident: 10.1016/j.cdp.2007.04.004_bib20 article-title: p53 genotypes and haplotypes associated with lung cancer susceptibility and ethnicity publication-title: J Natl Cancer Inst doi: 10.1093/jnci/94.9.681 contributor: fullname: Wu – volume: Suppl 1 start-page: 26 year: 2002 ident: 10.1016/j.cdp.2007.04.004_bib39 article-title: Screening for predisposing mutations in Polish families with Li-Fraumeni/Li-Fraumeni-like syndrome or with breast and ovarian cancer publication-title: Cancer Detect Prev contributor: fullname: Fiszer-Maliszewska – volume: 16 start-page: 2233 year: 1995 ident: 10.1016/j.cdp.2007.04.004_bib25 article-title: p53 poymorphisms and haplotypes in lung cancer publication-title: Carcinogenesis doi: 10.1093/carcin/16.9.2233 contributor: fullname: Birgander – volume: 14 start-page: 7805 year: 1994 ident: 10.1016/j.cdp.2007.04.004_bib3 article-title: Transactivation of the human p53 tumor suppressor gene by c-myc/max contributes to elevated mutant p53 expression in some tumors publication-title: Mol Cell Biol doi: 10.1128/MCB.14.12.7805 contributor: fullname: Roy – volume: 381 start-page: 201 year: 1997 ident: 10.1016/j.cdp.2007.04.004_bib15 article-title: Polymorphisms in the p53 gene in thyroid tumours and blood samples of children from areas in Belarus publication-title: Mutat Res doi: 10.1016/S0027-5107(97)00169-3 contributor: fullname: Hillebrandt – volume: 346 start-page: 182 year: 1995 ident: 10.1016/j.cdp.2007.04.004_bib34 article-title: p53 poymorphism in ovarian and bladder cancer publication-title: Lancet doi: 10.1016/S0140-6736(95)91239-8 contributor: fullname: Lancester – volume: 93 start-page: 620 year: 1994 ident: 10.1016/j.cdp.2007.04.004_bib12 article-title: Multiplex PCR screening detects small p53 deletions and insertions in human ovarian cancer cell lines publication-title: Hum Genet doi: 10.1007/BF00201559 contributor: fullname: Runnebaum |
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Snippet | Abstract Introduction : The biological significance of sequence variants in form of SNPs needs to be carefully evaluated, as conflicting associations with... Introduction: The biological significance of sequence variants in form of SNPs needs to be carefully evaluated, as conflicting associations with cancer... The biological significance of sequence variants in form of SNPs needs to be carefully evaluated, as conflicting associations with cancer predisposition have... |
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SubjectTerms | Adult Alleles Apoptosis Breast cancer Breast cancer risk Breast Neoplasms - ethnology Breast Neoplasms - genetics Cancer Case-Control Studies Cell cycle Deoxyribonucleic acid DNA DNA repair Epidemiology Exons Female Functional p53 polymorphisms Gene expression Gene Frequency Genes, p53 Genetic Predisposition to Disease Genotype combinations Haplotype frequencies Haplotypes Hematology, Oncology and Palliative Medicine Humans Introns Middle Aged Mutation p53 Polymerase Chain Reaction Polymorphism Polymorphism, Genetic Polymorphism, Restriction Fragment Length Risk Single nucleotide changes Studies Turkey |
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Title | p53 genotypes and haplotypes associated with risk of breast cancer |
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