Recombinant Protein Filovirus Vaccines Protect Cynomolgus Macaques From Ebola, Sudan, and Marburg Viruses

• Published in: Frontiers in immunology Vol. 12; p. 703986
• Main Authors: Lehrer, Axel T., Chuang, Eleanore, Namekar, Madhuri, Williams, Caitlin A., Wong, Teri Ann S., Lieberman, Michael M., Granados, Alex, Misamore, John, Yalley-Ogunro, Jake, Andersen, Hanne, Geisbert, Joan B., Agans, Krystle N., Cross, Robert W., Geisbert, Thomas W.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 18.08.2021
• Subjects: Animals; Ebola Vaccines - genetics; Ebola Vaccines - immunology; Ebola Vaccines - pharmacology; Ebola virus; Ebolavirus - genetics; Ebolavirus - immunology; filovirus; Hemorrhagic Fever, Ebola - epidemiology; Hemorrhagic Fever, Ebola - genetics; Hemorrhagic Fever, Ebola - immunology; Hemorrhagic Fever, Ebola - prevention & control; Humans; Immunology; Macaca fascicularis; Marburg virus; Marburg Virus Disease - epidemiology; Marburg Virus Disease - genetics; Marburg Virus Disease - immunology; Marburg Virus Disease - prevention & control; Marburgvirus - genetics; Marburgvirus - immunology; preclinical efficacy studies; Sudan virus; vaccine; Vaccines, Synthetic; Ebola virus; Sudan virus; vaccine; preclinical efficacy studies; Marburg virus; non-human primates; filovirus

Ebola (EBOV), Marburg (MARV) and Sudan (SUDV) viruses are the three filoviruses which have caused the most fatalities in humans. Transmission from animals into the human population typically causes outbreaks of limited scale in endemic regions. In contrast, the 2013-16 outbreak in several West Afric...