Ferroptosis Enhanced Diabetic Renal Tubular Injury via HIF-1α/HO-1 Pathway in db/db Mice

• Published in: Frontiers in endocrinology (Lausanne) Vol. 12; p. 626390
• Main Authors: Feng, Xiaomeng, Wang, Shuo, Sun, Zhencheng, Dong, Hengbei, Yu, Haitian, Huang, Mengxiu, Gao, Xia
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 18.02.2021
• Subjects: Animals; Diabetes Mellitus, Type 2 - metabolism; Diabetic Nephropathies - metabolism; diabetic nephropathy; Endocrinology; ferroptosis; Ferroptosis - physiology; heme oxygenase-1; Heme Oxygenase-1 - metabolism; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; hypoxia-inducible factor-1α; Kidney Tubules - metabolism; Lipid Peroxidation - physiology; Male; Mice; Oxidative Stress - physiology; Reactive Oxygen Species - metabolism; renal tubular injury; renal tubular injury; ferroptosis; hypoxia-inducible factor-1α; heme oxygenase-1; diabetic nephropathy
• ISSN: 1664-2392; 1664-2392
• DOI: 10.3389/fendo.2021.626390

Ferroptosis is a recently identified iron-dependent form of cell death as a result of increased reactive oxygen species (ROS) and lipid peroxidation. In this study, we investigated whether ferroptosis aggravated diabetic nephropathy (DN) and damaged renal tubules through hypoxia-inducible factor (HI...