MicroRNA-125a and -b inhibit A20 and MAVS to promote inflammation and impair antiviral response in COPD

• Published in: JCI insight Vol. 2; no. 7; p. e90443
• Main Authors: Hsu, Alan C-Y, Dua, Kamal, Starkey, Malcolm R, Haw, Tatt-Jhong, Nair, Prema M, Nichol, Kristy, Zammit, Nathan, Grey, Shane T, Baines, Katherine J, Foster, Paul S, Hansbro, Philip M, Wark, Peter A
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 06.04.2017

Influenza A virus (IAV) infections lead to severe inflammation in the airways. Patients with chronic obstructive pulmonary disease (COPD) characteristically have exaggerated airway inflammation and are more susceptible to infections with severe symptoms and increased mortality. The mechanisms that c...