Comparative Analysis of Gene Expression Profiles in the Adipose Tissue of Obese Adult Mice With Rapid Infantile Growth After Undernourishment In Utero

• Published in: Frontiers in endocrinology (Lausanne) Vol. 13; p. 818064
• Main Authors: Suzuki, Misako, Kohmura-Kobayashi, Yukiko, Ueda, Megumi, Furuta-Isomura, Naomi, Matsumoto, Masako, Oda, Tomoaki, Kawai, Kenta, Itoh, Toshiya, Matsuya, Madoka, Narumi, Megumi, Tamura, Naoaki, Uchida, Toshiyuki, Mochizuki, Kazuki, Itoh, Hiroaki
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 24.02.2022
• Subjects: adipose tissue; Adipose Tissue - metabolism; Animals; catch-up growth; Developmental Origins of Health and Disease (DOHaD); Diet, High-Fat - adverse effects; Endocrinology; inflammation; Inflammation - metabolism; Malnutrition; Metabolic Diseases - metabolism; Mice; Mice, Obese; obesity; Obesity - genetics; Obesity - metabolism; pregnancy; Transcriptome; Developmental Origins of Health and Disease (DOHaD); inflammation; pregnancy; adipose tissue; macrophage; low birth weight; catch-up growth; obesity

Rapid infantile growth (RG) markedly increases the risk of obesity and metabolic disorders in adulthood, particularly among neonates born small. To elucidate the molecular mechanisms by which RG following undernourishment (UN) contributes to the deterioration of adult fat deposition, we developed a...