HBV-Specific CD8+ T-Cell Tolerance in the Liver

• Published in: Frontiers in immunology Vol. 12; p. 721975
• Main Authors: Baudi, Ian, Kawashima, Keigo, Isogawa, Masanori
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 06.08.2021
• Subjects: Animals; Antigens - immunology; Biomarkers; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; co-inhibitory signaling; Cytotoxicity, Immunologic; Energy Metabolism; Epitopes, T-Lymphocyte - immunology; Hepatitis B - immunology; Hepatitis B - metabolism; Hepatitis B - pathology; Hepatitis B - virology; Hepatitis B virus - immunology; Host-Pathogen Interactions - immunology; Humans; Immune Tolerance; Immunology; Immunomodulation; interferon signaling; intrahepatic antigen recognition; Liver - immunology; Liver - metabolism; Liver - pathology; Liver - virology; liver tolerance; Lymphocyte Activation - immunology; metabolic regulation; T cell exhaustion; interferon signaling; intrahepatic antigen recognition; hepatitis B virus; T cell exhaustion; co-inhibitory signaling; liver tolerance; metabolic regulation

Hepatitis B virus (HBV) remains a leading cause of liver-related morbidity and mortality through chronic hepatitis that may progress to liver cirrhosis and cancer. The central role played by HBV-specific CD8+ T cells in the clearance of acute HBV infection, and HBV-related liver injury is now well e...