The metabolism of 4-aminobutyrate (GABA) in fungi

Information on the genetics and metabolism of 4-aminobutyrate (GABA) in yeasts and fungi is reviewed. In spite of ubiquitous occurrence, there is limited information on its function and biological role. Most fungi utilize GABA both as a carbon and a nitrogen source. Fungal endogenous GABA largely or...

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Published inMycological research Vol. 101; no. 4; pp. 403 - 409
Main Authors KUMAR, SANTOSH, PUNEKAR, NARAYAN S.
Format Journal Article
LanguageEnglish
Published Oxford Cambridge University Press 01.04.1997
Elsevier Ltd
Elsevier
Subjects
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Growth, nutrition, metabolism, transports, enzymes. Molecular biology
Metabolism
Metabolism. Physicochemical requirements
Microbiology
Mycology
Plant physiology and development
Fungi
Yeast
Enzymatic activity
Aminoacid
Cell cycle
GABA
Metabolism
Thallophyta
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Summary:Information on the genetics and metabolism of 4-aminobutyrate (GABA) in yeasts and fungi is reviewed. In spite of ubiquitous occurrence, there is limited information on its function and biological role. Most fungi utilize GABA both as a carbon and a nitrogen source. Fungal endogenous GABA largely originates from the decarboxylation of L-glutamate and is associated with sporulation/spore metabolism. Whatever its source, GABA is catabolized to succinate via succinicsemialdehyde. Taken together these steps define a potential bypass outside the classical tricarboxylic acid cycle. Evidence for the existence of such a functional bypass in fungi is reviewed. The role of GABA and its metabolism in various facets of fungal biology is gradually emerging.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:0953-7562
1469-8102
DOI:10.1017/S0953756296002742