Untargeted and Targeted Metabolomics Reveal the Underlying Mechanism of Aspirin Eugenol Ester Ameliorating Rat Hyperlipidemia via Inhibiting FXR to Induce CYP7A1

• Published in: Frontiers in pharmacology Vol. 12; p. 733789
• Main Authors: Xiao-Rong, Lu, Ning, Ma, Xi-Wang, Liu, Shi-Hong, Li, Zhe, Qin, Li-Xia, Bai, Ya-Jun, Yang, Jian-Yong, Li
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 25.11.2021
• Subjects: aspirin eugenol ester; bile acids; cholesterol; hyperlipidemia; metabolomics; Pharmacology; aspirin eugenol ester; cholesterol; hyperlipidemia; bile acids; metabolomics

Hyperlipidemia is an important lipid disorder and a risk factor for health. Aspirin eugenol ester (AEE) is a novel synthetic compound which is made up of two chemical structural units from aspirin and eugenol. Therapeutic effect of AEE on hyperlipidemia has been confirmed in animal model. But the ac...