Induction of IDO1 and Kynurenine by Serine Proteases Subtilisin, Prostate Specific Antigen, CD26 and HtrA: A New Form of Immunosuppression?

• Published in: Frontiers in immunology Vol. 13; p. 832989
• Main Authors: Clanchy, Felix I L, Huang, Yi-Shu, Ogbechi, Joy, Darlington, L Gail, Williams, Richard O, Stone, Trevor W
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 15.03.2022
• Subjects: Animals; CD26; Cytokines; Dipeptidyl Peptidase 4 - genetics; Humans; IDO1; Immunology; Immunosuppression Therapy; Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism; kynurenine; Kynurenine - metabolism; Male; Mammals - metabolism; Neoplasms; Prostate Specific Antigen; PSA; Serine Proteases; Staphylococcal Protein A; Subtilisin; DPP4; Prostate Specific Antigen; HtrA; CD26; kynurenine; serine proteases; IDO1; PSA

Several serine proteases have been linked to autoimmune disorders and tumour initiation although the mechanisms are not fully understood. Activation of the kynurenine pathway enzyme indoleamine-2,3-dioxygenase (IDO1) modulates cellular activity in the brain, tolerogenesis in the immune system and is...