The Distinct Roles of Sialyltransferases in Cancer Biology and Onco-Immunology

Aberrant glycosylation is a key feature of malignant transformation. Hypersialylation, the enhanced expression of sialic acid-terminated glycoconjugates on the cell surface, has been linked to immune evasion and metastatic spread, eventually by interaction with sialoglycan-binding lectins, including...

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Published in	Frontiers in immunology Vol. 12; p. 799861
Main Authors	Hugonnet, Marjolaine, Singh, Pushpita, Haas, Quentin, von Gunten, Stephan
Format	Journal Article
Language	English
Published	Switzerland Frontiers Media S.A 17.12.2021
Subjects	Animals cancer Glycosylation Humans Immunology Isoenzymes Neoplasms - enzymology Neoplasms - immunology Neoplasms - metabolism Protein Processing, Post-Translational Selectins - metabolism sialic acid Sialic Acid Binding Immunoglobulin-like Lectins - metabolism Sialic Acids - metabolism sialyltransferases Sialyltransferases - metabolism Substrate Specificity tumor glycosylation tumor immunology cancer tumor immunology sialic acid tumor glycosylation sialyltransferases
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Abstract	Aberrant glycosylation is a key feature of malignant transformation. Hypersialylation, the enhanced expression of sialic acid-terminated glycoconjugates on the cell surface, has been linked to immune evasion and metastatic spread, eventually by interaction with sialoglycan-binding lectins, including Siglecs and selectins. The biosynthesis of tumor-associated sialoglycans involves sialyltransferases, which are differentially expressed in cancer cells. In this review article, we provide an overview of the twenty human sialyltransferases and their roles in cancer biology and immunity. A better understanding of the individual contribution of select sialyltransferases to the tumor sialome may lead to more personalized strategies for the treatment of cancer.
AbstractList	Aberrant glycosylation is a key feature of malignant transformation. Hypersialylation, the enhanced expression of sialic acid-terminated glycoconjugates on the cell surface, has been linked to immune evasion and metastatic spread, eventually by interaction with sialoglycan-binding lectins, including Siglecs and selectins. The biosynthesis of tumor-associated sialoglycans involves sialyltransferases, which are differentially expressed in cancer cells. In this review article, we provide an overview of the twenty human sialyltransferases and their roles in cancer biology and immunity. A better understanding of the individual contribution of select sialyltransferases to the tumor sialome may lead to more personalized strategies for the treatment of cancer.
Author	Hugonnet, Marjolaine Singh, Pushpita von Gunten, Stephan Haas, Quentin
AuthorAffiliation	1 Institute of Pharmacology, University of Bern , Bern , Switzerland 2 Bern Center for Precision Medicine (BCPM), University of Bern , Bern , Switzerland
AuthorAffiliation_xml	– name: 2 Bern Center for Precision Medicine (BCPM), University of Bern , Bern , Switzerland – name: 1 Institute of Pharmacology, University of Bern , Bern , Switzerland
Author_xml	– sequence: 1 givenname: Marjolaine surname: Hugonnet fullname: Hugonnet, Marjolaine organization: Bern Center for Precision Medicine (BCPM), University of Bern, Bern, Switzerland – sequence: 2 givenname: Pushpita surname: Singh fullname: Singh, Pushpita organization: Institute of Pharmacology, University of Bern, Bern, Switzerland – sequence: 3 givenname: Quentin surname: Haas fullname: Haas, Quentin organization: Institute of Pharmacology, University of Bern, Bern, Switzerland – sequence: 4 givenname: Stephan surname: von Gunten fullname: von Gunten, Stephan organization: Bern Center for Precision Medicine (BCPM), University of Bern, Bern, Switzerland
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/34975914$$D View this record in MEDLINE/PubMed
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Keywords	cancer tumor immunology sialic acid tumor glycosylation sialyltransferases
Language	English
License	Copyright © 2021 Hugonnet, Singh, Haas and von Gunten. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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Notes	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Reviewed by: Behjatolah Monzavi-Karbassi, University of Arkansas for Medical Sciences, United States; Valeria I. Segatori, Universidad Nacional de Quilmes (UNQ), Argentina; Vered Padler-Karavani, Tel Aviv University, Israel; Thomas Boltje, Radboud University Nijmegen, Netherlands Edited by: Heinz Laubli, University Hospital of Basel, Switzerland This article was submitted to Cancer Immunity and Immunotherapy, a section of the journal Frontiers in Immunology
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SubjectTerms	Animals cancer Glycosylation Humans Immunology Isoenzymes Neoplasms - enzymology Neoplasms - immunology Neoplasms - metabolism Protein Processing, Post-Translational Selectins - metabolism sialic acid Sialic Acid Binding Immunoglobulin-like Lectins - metabolism Sialic Acids - metabolism sialyltransferases Sialyltransferases - metabolism Substrate Specificity tumor glycosylation tumor immunology
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Title	The Distinct Roles of Sialyltransferases in Cancer Biology and Onco-Immunology
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