Case Report: Markedly Long-Term Preservation of Pancreatic β‐Cell Function in a Subject With Elderly Onset of Type 1 Diabetes Mellitus Showing High-Titer Autoimmune Antibodies for Over 4 Years

• Published in: Frontiers in immunology Vol. 12; p. 752423
• Main Authors: Shigemoto, Ryo, Anno, Takatoshi, Kawasaki, Fumiko, Kaku, Kohei, Kaneto, Hideaki
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 25.11.2021
• Subjects: Aged; anti-GAD antibody; anti-IA-2 antibody; Autoantibodies - immunology; Autoantigens - immunology; autoimmune antibody; Diabetes Mellitus, Type 1 - immunology; Diabetes Mellitus, Type 1 - pathology; Disease Progression; elderly onset; Humans; Immunology; Insulin-Secreting Cells - pathology; Male; type 1 diabetes mellitus; β-cell function; anti-GAD antibody; type 1 diabetes mellitus; elderly onset; β-cell function; anti-IA-2 antibody; autoimmune antibody

Type 1 diabetes mellitus (T1DM) is mainly triggered by autoimmune β-cell destruction, usually leading to absolute insulin deficiency. Regarding the speed of β-cell destruction, there are large variations depending on age. In some adult cases, sufficient β-cell function is sometimes retained for a re...