A Tethering Complex Recruits SNAREs and Grabs Vesicles

Protein tethers can bridge gaps between membranes. Ren et al. (2009) now provide evidence that the yeast Dsl1 complex tethers vesicles to the endoplasmic reticulum (ER) by binding ER SNARE proteins at its base and capturing vesicles using a loop region that extends 20 nm from the ER membrane.

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Bibliographic Details
Published inCell Vol. 139; no. 6; pp. 1053 - 1055
Main Authors Schmitt, Hans Dieter, Jahn, Reinhard
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 11.12.2009
Subjects
Endoplasmic Reticulum - metabolism
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae Proteins - metabolism
SNARE Proteins - metabolism
Transport Vesicles - metabolism
Vesicular Transport Proteins - metabolism
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Summary:Protein tethers can bridge gaps between membranes. Ren et al. (2009) now provide evidence that the yeast Dsl1 complex tethers vesicles to the endoplasmic reticulum (ER) by binding ER SNARE proteins at its base and capturing vesicles using a loop region that extends 20 nm from the ER membrane.
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ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2009.11.041