The role of peroxiredoxin III in the ototoxic drug-induced mitochondrial apoptosis of cochlear hair cells

• Published in: Acta oto-laryngologica Vol. 128; no. 9; pp. 944 - 951
• Main Authors: Seok Choi, Ho, Joo Park, Kwang, Chul Hwang, Sung, Yi Park, Hun, Sun Kim, Young, Park, Keehyun
• Format: Journal Article
• Language: English
• Published: Stockholm Informa UK Ltd 01.01.2008; Taylor & Francis; Taylor and Francis
• Subjects: Anti-Bacterial Agents - pharmacology; Antineoplastic Agents - pharmacology; antioxidant; Apoptosis - drug effects; Apoptosis - physiology; Biological and medical sciences; Cell Culture Techniques; cisplatin; Cisplatin - pharmacology; Cochlea - drug effects; Cochlea - metabolism; Cochlea - pathology; gentamicin; Gentamicins - pharmacology; Hair Cells, Auditory - drug effects; Hair Cells, Auditory - metabolism; Hair Cells, Auditory - pathology; Humans; In Situ Nick-End Labeling; Medical sciences; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondria - pathology; Otorhinolaryngology. Stomatology; ototoxicity; Oxidative Stress - drug effects; Oxidative Stress - physiology; Peroxiredoxin III; Peroxiredoxins - physiology; Reactive Oxygen Species - metabolism; RNA Interference; ROS; Antineoplastic agent; Drug; Hair cell of the ear; Toxicity; Gentamicin; ENT; Antioxidant; Cisplatin; Alkylating agent; Antibiotic; Mitochondria; Aminoglycoside; ROS; Cochlea; Protein synthesis inhibitor; Antibacterial agent; Platinum II Complexes; Apoptosis; Ototoxicity

Conclusion. Peroxiredoxin (Prx) III plays a protective role in cisplatin- and gentamicin-induced apoptosis via a mitochondria-dependent pathway in cochlear hair cells. Objectives. The aim of the present study was to investigate the effects of the depletion of endogenous Prx III on oxidative damage t...