Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease

• Published in: The New England journal of medicine Vol. 361; no. 26; pp. 2518 - 2528
• Main Authors: Clarke, Robert, Peden, John F, Hopewell, Jemma C, Kyriakou, Theodosios, Goel, Anuj, Heath, Simon C, Parish, Sarah, Barlera, Simona, Franzosi, Maria Grazia, Rust, Stephan, Bennett, Derrick, Silveira, Angela, Malarstig, Anders, Green, Fiona R, Lathrop, Mark, Gigante, Bruna, Leander, Karin, de Faire, Ulf, Seedorf, Udo, Hamsten, Anders, Collins, Rory, Watkins, Hugh, Farrall, Martin
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 24.12.2009
• Subjects: Apolipoproteins; Cardiovascular disease; Case-Control Studies; Coronary Disease - blood; Coronary Disease - genetics; Coronary vessels; Genes; Genetic Markers; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Kringles - genetics; Likelihood Functions; Lipoprotein(a) - blood; Lipoprotein(a) - chemistry; Lipoprotein(a) - genetics; Lipoproteins; Myocardial Infarction - genetics; Oligonucleotide Array Sequence Analysis; Polymorphism, Single Nucleotide; Regression Analysis; Risk Factors; Systematic review

Using a novel gene chip, investigators identified single-nucleotide polymorphisms (SNPs) from three chromosomal regions, including the LPA locus, that were associated with the risk of coronary disease. Two SNPs in LPA were strongly associated with both the level of Lp(a) lipoprotein and the risk of...