Systematic Evaluation of the Effect of Formulation Variables on In Vitro Performance of Mometasone Furoate Suspension-Metered Dose Inhalers

• Published in: The AAPS journal Vol. 24; no. 1; p. 9
• Main Authors: Bachhav, Sagar S., Sheth, Poonam, Sandell, Dennis, Svensson, Mårten, Bhagwat, Sharvari, Conti, Denise S., Oguntimein, Oluwamurewa, Dhapare, Sneha, Saluja, Bhawana, Winner, Lawrence, Bulitta, Jürgen B., Hochhaus, Guenther
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 07.12.2021; Springer
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedicine; Biotechnology; Flat panel displays; Health aspects; Inhalers; Medical research; Medicine, Experimental; Mometasone; Monounsaturated fatty acids; Pharmacology/Toxicology; Pharmacy; Physician and patient; Product development; Research Article; critical quality attributes; metered dose inhalers; empirical correlations; delivered dose; fine particle dose; cascade impactor; mouth-throat models; mean dissolution time

The therapeutic benefits of metered dose inhalers (MDIs) in pulmonary disorders are mainly driven by aerosol performance, which depends on formulation variables (drug and excipients), device design, and patient interactions. The present study provides a comprehensive investigation to better understa...