Spatiotemporal changes in Netrin/Dscam1 signaling dictate axonal projection direction in Drosophila small ventral lateral clock neurons

• Published in: eLife Vol. 13
• Main Authors: Liu, Jingjing, Wang, Yuedong, Liu, Xian, Han, Junhai, Tian, Yao
• Format: Journal Article
• Language: English
• Published: England eLife Science Publications, Ltd 25.07.2024; eLife Sciences Publications Ltd; eLife Sciences Publications, Ltd
• Subjects: Animals; Axon guidance; axon projection; Axonogenesis; Axons - metabolism; Axons - physiology; Brain; Cell adhesion molecules; Cell Adhesion Molecules - genetics; Cell Adhesion Molecules - metabolism; Developmental Biology; Down's syndrome; Drosophila; Drosophila melanogaster - genetics; Drosophila melanogaster - metabolism; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; DSCAM protein; Dscam1; Growth cones; Horizontal cells; Insects; Larva - metabolism; Microenvironments; Mushroom bodies; Mushroom Bodies - metabolism; Netrin; Netrins - genetics; Netrins - metabolism; Neural cell adhesion molecule; Neurons; Neurons - metabolism; Neurons - physiology; Neuroscience; projection direction switch; s-LNvs; Signal Transduction; Canada; axon projection; s-LNvs; Netrin; developmental biology; neuroscience; D. melanogaster; Dscam1; projection direction switch

Axon projection is a spatial- and temporal-specific process in which the growth cone receives environmental signals guiding axons to their final destination. However, the mechanisms underlying changes in axonal projection direction without well-defined landmarks remain elusive. Here, we present evid...