Glutamine Deprivation Promotes the Generation and Mobilization of MDSCs by Enhancing Expression of G-CSF and GM-CSF

• Published in: Frontiers in immunology Vol. 11; p. 616367
• Main Authors: Sun, Hong-Wei, Wu, Wen-Chao, Chen, Hai-Tian, Xu, Yi-Tuo, Yang, Yan-Yan, Chen, Jing, Yu, Xing-Juan, Wang, Zilian, Shuang, Ze-Yu, Zheng, Limin
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 02.02.2021
• Subjects: bone marrow; G-CSF; glutamine; GM-CSF; Immunology; MDSC; MDSC; glutamine; GM-CSF; G-CSF; bone marrow

Solid tumors are often challenged by hypoxic and nutrient-deprived tumor microenvironments (TME) as tumors progress, due to limited perfusion and rapid nutrient consumption. While cancer cells can demonstrate the ability to survive in nutrient-deprived conditions through multiple intrinsic alteratio...