The IMMENSE Study: The Interplay Between iMMune and ENdothelial Cells in Mediating Cardiovascular Risk in Systemic Lupus Erythematosus

• Published in: Frontiers in immunology Vol. 11; p. 572876
• Main Authors: Bortoluzzi, Alessandra, Chighizola, Cecilia Beatrice, Fredi, Micaela, Raschi, Elena, Bodio, Caterina, Privitera, Daniela, Gonelli, Arianna, Silvagni, Ettore, Govoni, Marcello, Cavazzana, Ilaria, Airò, Paolo, Meroni, Pier Luigi, Tincani, Angela, Franceschini, Franco, Piantoni, Silvia, Casciano, Fabio
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 29.10.2020
• Subjects: Adult; angiogenic T cells; Animals; Cardiovascular Diseases - immunology; cardiovascular risk; Endothelial Cells - physiology; endothelial progenitor cells; Female; Human Umbilical Vein Endothelial Cells; Humans; Immunology; Immunophenotyping; Immunosenescence; Interleukin-8 - metabolism; Lupus Erythematosus, Systemic - immunology; Male; Risk; systemic lupus erythematosus; T-Lymphocyte Subsets - immunology; T-Lymphocytes - immunology; immunosenescence; systemic lupus erythematosus; angiogenic T cells; cardiovascular risk; endothelial progenitor cells

Patients with systemic lupus erythematosus (SLE) have a significant increase in cardiovascular (CV) risk although they display a preserved number of circulating angiogenic CD3 CD31 CXCR4 T cells (T ), a subpopulation of T cells which promotes repair of damaged endothelium. This happens due to the co...