Altered maturation of peripheral blood dendritic cells in patients with breast cancer

• Published in: British journal of cancer Vol. 89; no. 8; pp. 1463 - 1472
• Main Authors: DELLA BELLA, S, GENNARO, M, VACCARI, M, FERRARIS, C, NICOLA, S, RIVA, A, CLERICI, M, GRECO, M, VILLA, M. L
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 20.10.2003
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Breast Neoplasms - immunology; Breast Neoplasms - physiopathology; Case-Control Studies; Cell Differentiation; Cytokines - biosynthesis; Dendritic Cells - physiology; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Gynecology. Andrology. Obstetrics; Humans; Mammary gland diseases; Medical sciences; Middle Aged; Molecular and Cellular Pathology; Tumors; Human; Dendritic cell; Immune response; tumour immunity; Accessory cell; Cellular immunity; Malignant tumor; Cell differentiation; Mammary gland diseases; Spermine; Antigen presenting cell; cell surface molecules; cytokines; dendntic cells; Mammary gland

Tumours have at least two mechanisms that can alter dendritic cell (DC) maturation and function. The first affects the ability of haematopoietic progenitors to differentiate into functional DCs; the second affects their differentiation from CD14+ monocytes, promoting an early but dysfunctional matur...