uhrf1 and dnmt1 Loss Induces an Immune Response in Zebrafish Livers Due to Viral Mimicry by Transposable Elements

• Published in: Frontiers in immunology Vol. 12; p. 627926
• Main Authors: Magnani, Elena, Macchi, Filippo, Madakashira, Bhavani P., Zhang, Chi, Alaydaroos, Fatima, Sadler, Kirsten C.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 29.03.2021
• Subjects: dnmt1; Immunology; interferon; TNFa; transposable element; uhrf1; zebrafish; TNFa; dnmt1; transposable element; DNA methylation; uhrf1; zebrafish; interferon

Activation of transposable elements (TEs) can cause cellular damage. Cytoplasmic nucleic acid sensing pathways evolved to detect pathogens, but can also serve to cull cells with inappropriate TE activation as TEs can be viral mimetics. Epigenetic silencing of TEs is mediated in part by DNA methylati...