Asymptomatic Transmissibility Calls for Implementing a Zero-COVID Strategy to End the Current Global Crisis

The coronavirus disease 2019 (COVID-19) pandemic has led to unprecedented global challenges. A zero-COVID strategy is needed to end the crisis, but there is a lack of biological evidence. In the present study, we collected available data on SARS, MERS, and COVID-19 to perform a comprehensive compara...

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Published inFrontiers in cellular and infection microbiology Vol. 12; p. 836409
Main Authors Zhang, Chaobao, Wang, Hongzhi, Wen, Zilu, Gu, Mingjun, Liu, Lianyong, Li, Xiangqi
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 19.04.2022
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Abstract The coronavirus disease 2019 (COVID-19) pandemic has led to unprecedented global challenges. A zero-COVID strategy is needed to end the crisis, but there is a lack of biological evidence. In the present study, we collected available data on SARS, MERS, and COVID-19 to perform a comprehensive comparative analysis and visualization. The study results revealed that the fatality rate of COVID-19 is low, whereas its death toll is high compared to SARS and MERS. Moreover, COVID-19 had a higher asymptomatic rate. In particular, COVID-19 exhibited unique asymptomatic transmissibility. Further, we developed a foolproof operating software in Python language to simulate COVID-19 spread in Wuhan, showing that the cumulative cases of existing asymptomatic spread would be over 100 times higher than that of only symptomatic spread. This confirmed the essential role of asymptomatic transmissibility in the uncontrolled global spread of COVID-19, which enables the necessity of implementing the zero-COVID policy. In conclusion, we revealed the triggering role of the asymptomatic transmissibility of COVID-19 in this unprecedented global crisis, which offers support to the zero-COVID strategy against the recurring COVID-19 spread.
AbstractList The coronavirus disease 2019 (COVID-19) pandemic has led to unprecedented global challenges. A zero-COVID strategy is needed to end the crisis, but there is a lack of biological evidence. In the present study, we collected available data on SARS, MERS, and COVID-19 to perform a comprehensive comparative analysis and visualization. The study results revealed that the fatality rate of COVID-19 is low, whereas its death toll is high compared to SARS and MERS. Moreover, COVID-19 had a higher asymptomatic rate. In particular, COVID-19 exhibited unique asymptomatic transmissibility. Further, we developed a foolproof operating software in Python language to simulate COVID-19 spread in Wuhan, showing that the cumulative cases of existing asymptomatic spread would be over 100 times higher than that of only symptomatic spread. This confirmed the essential role of asymptomatic transmissibility in the uncontrolled global spread of COVID-19, which enables the necessity of implementing the zero-COVID policy. In conclusion, we revealed the triggering role of the asymptomatic transmissibility of COVID-19 in this unprecedented global crisis, which offers support to the zero-COVID strategy against the recurring COVID-19 spread.
Author Li, Xiangqi
Wen, Zilu
Zhang, Chaobao
Wang, Hongzhi
Gu, Mingjun
Liu, Lianyong
AuthorAffiliation 5 Department of Scientific Research, Shanghai Public Health Clinical Center , Shanghai , China
6 Department of Endocrinology, Gongli Hospital, The Second Military Medical University , Shanghai , China
1 Department of Geriatric Medicine, Huadong Hospital, Shanghai Medical College, Fudan University , Shanghai , China
4 Shanghai Key Laboratory of Magnetic Resonance, East China Normal University , Shanghai , China
2 Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital , Shanghai , China
7 Department of Endocrinology, Punan Hospital , Shanghai , China
3 Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences , Shanghai , China
AuthorAffiliation_xml – name: 5 Department of Scientific Research, Shanghai Public Health Clinical Center , Shanghai , China
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– name: 7 Department of Endocrinology, Punan Hospital , Shanghai , China
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– name: 4 Shanghai Key Laboratory of Magnetic Resonance, East China Normal University , Shanghai , China
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Cites_doi 10.1126/science.abb3221
10.1016/S2468-2667(20)30082-7
10.1038/d41586-020-00822-x
10.1038/s41392-021-00525-3
10.2807/1560-7917.ES.2020.25.13.2000323
10.1001/jama.2020.2565
10.1016/S0140-6736(20)30154-9
10.1093/epirev/mxz009
10.1126/science.abb7015
10.1016/j.csbj.2021.04.004
10.1016/j.clinimag.2020.02.008
10.1096/fj.202000502
10.2807/1560-7917.ES.2020.25.10.2000180
10.1007/s11427-020-1661-4
10.7554/eLife.55570.sa2
10.1016/S2214-109X(20)30074-7
10.3201/eid0911.030421
10.1016/S1473-3099(20)30162-6
10.1093/infdis/jiaa119
10.1136/bmj.m3859
10.1056/NEJMc2001468
10.1016/j.chom.2021.04.007
10.1016/j.cell.2021.02.037
10.4103/ijmr.IJMR_504_20
10.1126/science.acx9657
10.1126/science.abb7314
10.2174/0929867327666201103162810
10.1093/abbs/gmab120
10.3760/cma.j.issn.0254-6450.2020.02.003
10.1007/s11684-020-0766-9
10.1093/cid/ciaa424
10.1001/jama.2020.1585
10.3201/eid2607.200718
10.1056/NEJMc2001899
10.1016/j.micinf.2020.02.006
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Keywords COVID-19
software, artificial intelligence
asymptomatic spread
SARS-CoV-2
containment measure
zero-COVID strategy
Language English
License Copyright © 2022 Zhang, Wang, Wen, Gu, Liu and Li.
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These authors have contributed equally to this work
This article was submitted to Microbiome in Health and Disease, a section of the journal Frontiers in Cellular and Infection Microbiology
Edited by: Carlo Contini, University of Ferrara, Italy
Reviewed by: Agustin Valenzuela-Fernandez, University of La Laguna, Spain; Zeinab Abdelrahman, Zhejiang University, China; Sk. Abdus Samad, Khulna University, Bangladesh
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References Gao (B6) 2021; 6
Li (B15) 2020; 368
Zhang (B34) 2020
Koo (B12) 2020
Qiu (B23) 2020
Wang (B30) 2020
Wang (B32) 2021; 19
Li (B13) 2020; 26
Verelst (B28) 2020; 25
Liu (B16) 2021; 28
Zhou (B35) 2021; 184
Li (B17) 2020; 34
Bayham (B2) 2020
Xiao (B33) 2021; 53
Hu (B11) 2020
Tetro (B27) 2020; 22
Hellewell (B9) 2020; 8
Mizumoto (B20) 2020; 25
Chan (B4) 2020
Grant (B8) 2019
Lin (B14) 2020; 63
Bai (B1) 2020; 323
Mandal (B18) 2020
Normile (B21) 2021; 374
Rothe (B25) 2020; 382
Chan (B3) 2003; 9
Shi (B26) 2020
Rockx (B24) 2020
Wang (B29) 2021; 29
McKee (B19) 2020; 371
Danis (B5) 2020
(B22) 2020; 41
Wang (B31) 2020
Gostic (B7) 2020; 9
Hoehl (B10) 2020; 382
References_xml – volume: 368
  start-page: 489
  year: 2020
  ident: B15
  article-title: Substantial Undocumented Infection Facilitates the Rapid Dissemination of Novel Coronavirus (SARS-Cov-2)
  publication-title: Science
  doi: 10.1126/science.abb3221
  contributor:
    fullname: Li
– year: 2020
  ident: B2
  article-title: Impact of School Closures for COVID-19 on the US Health-Care Workforce and Net Mortality: A Modelling Study
  publication-title: Lancet Public Health
  doi: 10.1016/S2468-2667(20)30082-7
  contributor:
    fullname: Bayham
– year: 2020
  ident: B23
  article-title: Covert Coronavirus Infections Could be Seeding New Outbreaks
  publication-title: Nature
  doi: 10.1038/d41586-020-00822-x
  contributor:
    fullname: Qiu
– volume: 6
  start-page: 113
  year: 2021
  ident: B6
  article-title: The Dichotomous and Incomplete Adaptive Immunity in COVID-19 Patients With Different Disease Severity
  publication-title: Signal Transduct. Target Ther.
  doi: 10.1038/s41392-021-00525-3
  contributor:
    fullname: Gao
– volume: 25
  year: 2020
  ident: B28
  article-title: Indications for Healthcare Surge Capacity in European Countries Facing an Exponential Increase in Coronavirus Disease (COVID-19) Cases, March 2020
  publication-title: Euro. Surveill
  doi: 10.2807/1560-7917.ES.2020.25.13.2000323
  contributor:
    fullname: Verelst
– volume: 323
  start-page: 1406
  year: 2020
  ident: B1
  article-title: Presumed Asymptomatic Carrier Transmission of COVID-19
  publication-title: JAMA
  doi: 10.1001/jama.2020.2565
  contributor:
    fullname: Bai
– year: 2020
  ident: B4
  article-title: A Familial Cluster of Pneumonia Associated With the 2019 Novel Coronavirus Indicating Person-to-Person Transmission: A Study of a Family Cluster
  publication-title: Lancet
  doi: 10.1016/S0140-6736(20)30154-9
  contributor:
    fullname: Chan
– year: 2019
  ident: B8
  article-title: A Review of Asymptomatic and Sub-Clinical Middle East Respiratory Syndrome Coronavirus Infections
  publication-title: Epidemiol. Rev
  doi: 10.1093/epirev/mxz009
  contributor:
    fullname: Grant
– year: 2020
  ident: B26
  article-title: Susceptibility of Ferrets, Cats, Dogs, and Other Domesticated Animals to SARS-Coronavirus 2
  publication-title: Science
  doi: 10.1126/science.abb7015
  contributor:
    fullname: Shi
– volume: 19
  start-page: 1966
  year: 2021
  ident: B32
  article-title: K-SEIR-Sim: A Simple Customized Software for Simulating the Spread of Infectious Diseases
  publication-title: Comput. Struct. Biotechnol. J.
  doi: 10.1016/j.csbj.2021.04.004
  contributor:
    fullname: Wang
– volume: 63
  start-page: 7
  year: 2020
  ident: B14
  article-title: Asymptomatic Novel Coronavirus Pneumonia Patient Outside Wuhan: The Value of CT Images in the Course of the Disease
  publication-title: Clin. Imaging
  doi: 10.1016/j.clinimag.2020.02.008
  contributor:
    fullname: Lin
– volume: 34
  start-page: 6008
  year: 2020
  ident: B17
  article-title: Existing Bitter Medicines for Fighting 2019-nCoV-Associated Infectious Diseases
  publication-title: FASEB J
  doi: 10.1096/fj.202000502
  contributor:
    fullname: Li
– volume: 25
  year: 2020
  ident: B20
  article-title: Estimating the Asymptomatic Proportion of Coronavirus Disease 2019 (COVID-19) Cases on Board the Diamond Princess Cruise Ship, Yokohama, Japan 2020
  publication-title: Euro. Surveill
  doi: 10.2807/1560-7917.ES.2020.25.10.2000180
  contributor:
    fullname: Mizumoto
– year: 2020
  ident: B11
  article-title: Clinical Characteristics of 24 Asymptomatic Infections With COVID-19 Screened Among Close Contacts in Nanjing, China
  publication-title: Sci. China Life Sci
  doi: 10.1007/s11427-020-1661-4
  contributor:
    fullname: Hu
– volume: 9
  year: 2020
  ident: B7
  article-title: Estimated Effectiveness of Symptom and Risk Screening to Prevent the Spread of COVID-19
  publication-title: Elife
  doi: 10.7554/eLife.55570.sa2
  contributor:
    fullname: Gostic
– volume: 8
  start-page: e488
  year: 2020
  ident: B9
  article-title: Feasibility of Controlling COVID-19 Outbreaks by Isolation of Cases and Contacts
  publication-title: Lancet Glob. Health
  doi: 10.1016/S2214-109X(20)30074-7
  contributor:
    fullname: Hellewell
– volume: 9
  start-page: 1453
  year: 2003
  ident: B3
  article-title: Severe Acute Respiratory Syndrome-Associated Coronavirus Infection
  publication-title: Emerg. Infect. Dis.
  doi: 10.3201/eid0911.030421
  contributor:
    fullname: Chan
– year: 2020
  ident: B12
  article-title: Interventions to Mitigate Early Spread of SARS-Cov-2 in Singapore: A Modelling Study
  publication-title: Lancet Infect. Dis
  doi: 10.1016/S1473-3099(20)30162-6
  contributor:
    fullname: Koo
– year: 2020
  ident: B31
  article-title: Clinical Outcome of 55 Asymptomatic Cases at the Time of Hospital Admission Infected With SARS-Coronavirus-2 in Shenzhen, China
  publication-title: J. Infect. Dis
  doi: 10.1093/infdis/jiaa119
  contributor:
    fullname: Wang
– volume: 371
  start-page: m3859
  year: 2020
  ident: B19
  article-title: Achieving Zero Covid is Not Easy, But the Alternative is Far Worse
  publication-title: BMJ
  doi: 10.1136/bmj.m3859
  contributor:
    fullname: McKee
– volume: 382
  start-page: 970
  year: 2020
  ident: B25
  article-title: Transmission of 2019-NCoV Infection From an Asymptomatic Contact in Germany
  publication-title: N Engl. J. Med.
  doi: 10.1056/NEJMc2001468
  contributor:
    fullname: Rothe
– volume: 29
  start-page: 747
  year: 2021
  ident: B29
  article-title: Increased Resistance of SARS-CoV-2 Variant P.1 to Antibody Neutralization
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2021.04.007
  contributor:
    fullname: Wang
– volume: 184
  start-page: 2348
  year: 2021
  ident: B35
  article-title: Evidence of Escape of SARS-CoV-2 Variant B.1.351 From Natural and Vaccine-Induced Sera
  publication-title: Cell
  doi: 10.1016/j.cell.2021.02.037
  contributor:
    fullname: Zhou
– year: 2020
  ident: B18
  article-title: Prudent Public Health Intervention Strategies to Control the Coronavirus Disease 2019 Transmission in India: A Mathematical Model-Based Approach
  publication-title: Indian J. Med. Res
  doi: 10.4103/ijmr.IJMR_504_20
  contributor:
    fullname: Mandal
– volume: 374
  start-page: 924
  year: 2021
  ident: B21
  article-title: ‘Zero Covid’ is Getting Harder-But China is Sticking With It
  publication-title: Science
  doi: 10.1126/science.acx9657
  contributor:
    fullname: Normile
– year: 2020
  ident: B24
  article-title: Comparative Pathogenesis of COVID-19, MERS, and SARS in a Nonhuman Primate Model
  publication-title: Science
  doi: 10.1126/science.abb7314
  contributor:
    fullname: Rockx
– volume: 28
  start-page: 5449
  year: 2021
  ident: B16
  article-title: Rediscovery of Caffeine: An Excellent Drug for Improving Patient Outcomes While Fighting WARS
  publication-title: Curr. Med. Chem.
  doi: 10.2174/0929867327666201103162810
  contributor:
    fullname: Liu
– volume: 53
  start-page: 1575
  year: 2021
  ident: B33
  article-title: Historic Opportunity: Artificial Intelligence Interventions in COVID-19 and Other Unknown Diseases
  publication-title: Acta Biochim. Biophys. Sin. (Shanghai)
  doi: 10.1093/abbs/gmab120
  contributor:
    fullname: Xiao
– volume: 41
  start-page: 145
  year: 2020
  ident: B22
  article-title: The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19) in China
  publication-title: Zhonghua Liu Xing Bing Xue Za Zhi
  doi: 10.3760/cma.j.issn.0254-6450.2020.02.003
– year: 2020
  ident: B34
  article-title: COVID-19 Containment: China Provides Important Lessons for Global Response
  publication-title: Front. Med
  doi: 10.1007/s11684-020-0766-9
  contributor:
    fullname: Zhang
– year: 2020
  ident: B5
  article-title: Cluster of Coronavirus Disease 2019 (Covid-19) in the French French Alps 2020
  publication-title: Clin. Infect. Dis
  doi: 10.1093/cid/ciaa424
  contributor:
    fullname: Danis
– year: 2020
  ident: B30
  article-title: Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China
  publication-title: JAMA
  doi: 10.1001/jama.2020.1585
  contributor:
    fullname: Wang
– volume: 26
  year: 2020
  ident: B13
  article-title: Asymptomatic and Human-to-Human Transmission of SARS-Cov-2 in a 2-Family Cluster, Xuzhou, China
  publication-title: Emerg. Infect. Dis.
  doi: 10.3201/eid2607.200718
  contributor:
    fullname: Li
– volume: 382
  start-page: 1278
  year: 2020
  ident: B10
  article-title: Evidence of SARS-Cov-2 Infection in Returning Travelers From Wuhan, China
  publication-title: N Engl. J. Med.
  doi: 10.1056/NEJMc2001899
  contributor:
    fullname: Hoehl
– volume: 22
  start-page: 72
  year: 2020
  ident: B27
  article-title: Is COVID-19 Receiving ADE From Other Coronaviruses
  publication-title: Microbes Infect.
  doi: 10.1016/j.micinf.2020.02.006
  contributor:
    fullname: Tetro
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Snippet The coronavirus disease 2019 (COVID-19) pandemic has led to unprecedented global challenges. A zero-COVID strategy is needed to end the crisis, but there is a...
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SubjectTerms asymptomatic spread
Cellular and Infection Microbiology
containment measure
COVID-19
COVID-19 - epidemiology
Humans
Pandemics - prevention & control
SARS-CoV-2
software, artificial intelligence
zero-COVID strategy
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Title Asymptomatic Transmissibility Calls for Implementing a Zero-COVID Strategy to End the Current Global Crisis
URI https://www.ncbi.nlm.nih.gov/pubmed/35521224
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