The fractalkine/Cx3CR1 system is implicated in the development of metabolic visceral adipose tissue inflammation in obesity

• Published in: Brain, behavior, and immunity Vol. 38; pp. 25 - 35
• Main Authors: Polyák, Ágnes, Ferenczi, Szilamér, Dénes, Ádám, Winkler, Zsuzsanna, Kriszt, Rókus, Pintér-Kübler, Bernadett, Kovács, Krisztina J
• Format: Journal Article
• Language: English
• Published: Netherlands 01.05.2014
• Subjects: Adipose Tissue - metabolism; Allergy and Immunology; Animals; Chemokine CX3CL1 - metabolism; Diet, High-Fat; Hypothalamo-Hypophyseal System - metabolism; Inflammation - metabolism; Male; Mice; Mice, Knockout; Obesity - metabolism; Pituitary-Adrenal System - metabolism; Psychiatry; TNFα; GTT; Liver; HFD; neuropeptide Y; ACTH; subcutaneous white adipose tissue; adrenocorticotropic hormone; high fat diet; interleukin-6; HSD1, 11βHSD1; monocyte chemotactic protein-1; RT-PCR; ethylenediaminetetraacetic acid; HSD1; deoxyribonuclease; Cx3CR1; ARG1; pro-opiomelanocortin; FKN; IL-1β; green fluorescent protein; IL-1α; IBAT; IL-10; IL-6; SWAT; uncoupling protein 1; CORT; radioimmunoassay; ND; adipose tissue macrophages; CRH; IL-1α and β; 11β-hydroxysteroid dehydrogenase type 1; GAPDH; arginase 1; glyceraldehyde 3-phosphate dehydrogenase; Interleukin-1; MCP-1; epididymal white adipose tissue; glucose tolerance test; interscapular brown adipose tissue; white adipose tissue; EWAT; UCP1; fat-enriched diet; WAT; Hypothalamus; NACHT, LRR and PYD domains-containing protein 3; fractalkine receptor; interleukin-10; FatED; GFP; tumor necrosis factor alpha; fractalkine; interleukin-1 alpha; NPY; NLRP3; MCP-1, CCL2; corticotropin-releasing hormone; real-time polymerase chain reaction; ACK; RIA; EDTA; Cx3CL1; NLR family, pyrin domain containing 3; POMC; interleukin-1 beta; brown adipose tissue; BAT; NALP3; Dnase; ATM; ammonium–chloride–potassium lysing buffer; corticosterone; normal diet; White adipose tissue; Brown adipose tissue; High fat diet
• ISSN: 0889-1591; 1090-2139
• DOI: 10.1016/j.bbi.2014.01.010

Highlight • Mice with impaired fractalkine signaling are protected from diet-induced obesity and related metabolic inflammation in the visceral adipose tissue.