Co-Expression Networks Unveiled Long Non-Coding RNAs as Molecular Targets of Drugs Used to Treat Bipolar Disorder

• Published in: Frontiers in pharmacology Vol. 13; p. 873271
• Main Authors: Truong, Trang TT, Bortolasci, Chiara C., Spolding, Briana, Panizzutti, Bruna, Liu, Zoe SJ, Kidnapillai, Srisaiyini, Richardson, Mark, Gray, Laura, Smith, Craig M., Dean, Olivia M., Kim, Jee Hyun, Berk, Michael, Walder, Ken
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 08.04.2022
• Subjects: bipolar disorders; co-expression network; lncRNAs; mood stabilizers; Pharmacology; treatments; WGCNA; lncRNAs; mood disorders; bipolar disorders; mood stabilizers; WGCNA; treatments; co-expression network

Long non-coding RNAs (lncRNAs) may play a role in psychiatric diseases including bipolar disorder (BD). We investigated mRNA-lncRNA co-expression patterns in neuronal-like cells treated with widely prescribed BD medications. The aim was to unveil insights into the complex mechanisms of BD medication...