Axon loss is responsible for chronic neurological deficit following inflammatory demyelination in the rat

• Published in: Experimental neurology Vol. 197; no. 2; pp. 373 - 385
• Main Authors: Papadopoulos, Dimitrios, Pham-Dinh, Danielle, Reynolds, Richard
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.02.2006; Elsevier
• Subjects: Animals; Atrophy; Axonal loss; Axons - metabolism; Axons - pathology; Biological and medical sciences; CD11b Antigen - metabolism; Demyelination; Disease Models, Animal; EAE; Encephalomyelitis, Autoimmune, Experimental - chemically induced; Encephalomyelitis, Autoimmune, Experimental - metabolism; Encephalomyelitis, Autoimmune, Experimental - pathology; Encephalomyelitis, Autoimmune, Experimental - physiopathology; Female; Injuries of the nervous system and the skull. Diseases due to physical agents; Medical sciences; MOG; Multiple sclerosis; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Multiple Sclerosis, Relapsing-Remitting - pathology; Multiple Sclerosis, Relapsing-Remitting - physiopathology; Myelin Proteins; Myelin Sheath - metabolism; Myelin Sheath - pathology; Myelin-Associated Glycoprotein; Myelin-Oligodendrocyte Glycoprotein; Myelitis - etiology; Myelitis - pathology; Nerve Degeneration - metabolism; Nerve Degeneration - pathology; Nerve Degeneration - physiopathology; Neurology; Rats; Remyelination; Spinal Cord - pathology; Spinal cord atrophy; Statistics as Topic; Time Factors; Traumas. Diseases due to physical agents; Multiple sclerosis; MOG; Demyelination; EAE; Spinal cord atrophy; Axonal loss; Remyelination; Autoimmunity; Immunohistochemistry; Spinal cord; Relapse; Rat; Pathogenesis; Central nervous system; Ox; Inflammatory disease; Atrophy; Disability; Irreversible; Neurological disorder; Ungulata; Evaluation; Nervous system diseases; Mimic; Myelin; Rodentia; Axon; Inflammation; Section; Vertebrata; Anatomic pathology; Chronic; Mammalia; Onset time; Treatment; Mouse; Animal; Central nervous system disease; Severity score; Models; Artiodactyla; Macrophage

Axonal loss is now considered a consistent feature of MS pathology and evidence suggests that its accumulation may be the pathological correlate for the development of irreversible disability. In this study, we investigated the features of axonal loss in myelin autoimmunity and tested the hypothesis...