Microbial Phagocytic Receptors and Their Potential Involvement in Cytokine Induction in Macrophages

• Published in: Frontiers in immunology Vol. 12; p. 662063
• Main Authors: Fu, Yan Lin, Harrison, Rene E
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 29.04.2021
• Subjects: Animals; Antigens, Bacterial - immunology; cytokine; Cytokines - biosynthesis; Cytokines - immunology; Humans; Immunity, Innate; Immunology; inflammation; macrophage; Macrophages - immunology; Mice; NF-kappa B p50 Subunit - immunology; phagocyte; Phagocytes - immunology; Phagocytes - microbiology; Phagocytosis - immunology; Phagosomes - immunology; Phagosomes - microbiology; receptor; Signal Transduction - immunology; Toll-Like Receptors - immunology; cytokine; macrophage; receptor; inflammation; phagocyte

Phagocytosis is an essential process for the uptake of large (>0.5 µm) particulate matter including microbes and dying cells. Specialized cells in the body perform phagocytosis which is enabled by cell surface receptors that recognize and bind target cells. Professional phagocytes play a prominen...