Hydrogen Sulfide Promotes Thyroid Hormone Synthesis and Secretion by Upregulating Sirtuin-1

• Published in: Frontiers in pharmacology Vol. 13; p. 838248
• Main Authors: Zhao, Xue, Cao, Yedi, Jin, Hongfang, Wang, Xiuli, Zhang, Lanbo, Zhang, Yang, Yu, Yang, Huang, Youyuan, Gao, Ying, Zhang, Junqing
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 10.02.2022
• Subjects: hydrogen sulfide; hypothyroidism; Pharmacology; sirtuin-1; thyrocytes; thyroid hormone synthesis and secretion; thyroid hormone synthesis and secretion; hydrogen sulfide; thyrocytes; hypothyroidism; sirtuin-1

Objective: One mechanism of hypothyroidism involves the disruption of thyroid hormone synthesis and secretion by thyrocytes. Hydrogen sulfide (H 2 S), as a gas signaling molecule, participates in many physiopathologic processes by upregulating sirtuin-1 (SIRT1). The aim of the current study was to e...