Aryloxyalkanoic Acids as Non-Covalent Modifiers of the Allosteric Properties of Hemoglobin

• Published in: Molecules (Basel, Switzerland) Vol. 21; no. 8; p. 1057
• Main Authors: Omar, Abdelsattar M, Mahran, Mona A, Ghatge, Mohini S, Bamane, Faida H A, Ahmed, Mostafa H, El-Araby, Moustafa E, Abdulmalik, Osheiza, Safo, Martin K
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 13.08.2016; MDPI AG
• Subjects: Allosteric Regulation - drug effects; antisickling; Antisickling Agents - chemical synthesis; Antisickling Agents - chemistry; Antisickling Agents - pharmacology; aryloxyalkanoic acids; Binding Sites; Clofibric Acid - chemistry; Clofibric Acid - pharmacology; crystal structure; halogenated benzene; hemoglobin; Hemoglobins - chemistry; Hemoglobins - metabolism; high affinity; imidazole; low affinity; Models, Molecular; Molecular Conformation; oxygen equilibrium curve; Protein Binding; sickle cell disease; Structure-Activity Relationship; aryloxyalkanoic acids; high affinity; imidazole; low affinity; crystal structure; oxygen equilibrium curve; halogenated benzene; antisickling; hemoglobin; sickle cell disease

Hemoglobin (Hb) modifiers that stereospecifically inhibit sickle hemoglobin polymer formation and/or allosterically increase Hb affinity for oxygen have been shown to prevent the primary pathophysiology of sickle cell disease (SCD), specifically, Hb polymerization and red blood cell sickling. Severa...