Integrated Analysis of Prognostic Genes Associated With Ischemia-Reperfusion Injury in Renal Transplantation

• Published in: Frontiers in immunology Vol. 12; p. 747020
• Main Authors: Zhang, Di, Wang, Yicun, Zeng, Song, Zhang, Min, Zhang, Xin, Wang, Yuxuan, Zhang, Zijian, Wang, Xi, Hu, Xiaopeng
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 07.09.2021
• Subjects: Animals; Female; Gene Expression Profiling; graft survival; Humans; Immediate-Early Proteins - genetics; immune cell; Immunology; ischemia–reperfusion injury; Kidney Transplantation - adverse effects; Male; Mice; Mice, Inbred C57BL; NF-κB signaling; Prognosis; renal transplantation; Reperfusion Injury - genetics; rhoB GTP-Binding Protein - genetics; Transcriptome; Tumor Suppressor Proteins - genetics; NF-κB signaling; graft survival; immune cell; ischemia–reperfusion injury; renal transplantation

Ischemia-reperfusion injury (IRI) remains an inevitable and major challenge in renal transplantation. The current study aims to obtain deep insights into underlying mechanisms and seek prognostic genes as potential therapeutic targets for renal IRI (RIRI). After systematically screening the Gene Exp...