Intestinal Fibrosis in Inflammatory Bowel Disease and the Prospects of Mesenchymal Stem Cell Therapy

Intestinal fibrosis is an important complication of inflammatory bowel disease (IBD). In the course of the development of fibrosis, certain parts of the intestine become narrowed, significantly destroying the structure and function of the intestine and affecting the quality of life of patients. Chro...

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Published inFrontiers in immunology Vol. 13; p. 835005
Main Authors Wang, Yifei, Huang, Bin, Jin, Tao, Ocansey, Dickson Kofi Wiredu, Jiang, Jiajia, Mao, Fei
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 18.03.2022
Subjects
Fibrosis
Humans
IBD
immune cells
Immunology
Inflammatory Bowel Diseases - metabolism
intestinal fibrosis
Intestines - pathology
mechanism
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells - metabolism
MSC
Quality of Life
therapy
immune cells
IBD
MSC
intestinal fibrosis
mechanism
therapy
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Abstract Intestinal fibrosis is an important complication of inflammatory bowel disease (IBD). In the course of the development of fibrosis, certain parts of the intestine become narrowed, significantly destroying the structure and function of the intestine and affecting the quality of life of patients. Chronic inflammation is an important initiating factor of fibrosis. Unfortunately, the existing anti-inflammatory drugs cannot effectively prevent and alleviate fibrosis, and there is no effective anti-fibrotic drug, which makes surgical treatment the mainstream treatment for intestinal fibrosis and stenosis. Mesenchymal stem cells (MSCs) are capable of tissue regeneration and repair through their self-differentiation, secretion of cytokines, and secretion of extracellular vesicles. MSCs have been shown to play an important therapeutic role in the fibrosis of many organs. However, the role of MSC in intestinal fibrosis largely remained unexplored. This review summarizes the mechanism of intestinal fibrosis, including the role of immune cells, TGF-β, and the gut microbiome and metabolites. Available treatment options for fibrosis, particularly, MSCs are also discussed.
AbstractList Intestinal fibrosis is an important complication of inflammatory bowel disease (IBD). In the course of the development of fibrosis, certain parts of the intestine become narrowed, significantly destroying the structure and function of the intestine and affecting the quality of life of patients. Chronic inflammation is an important initiating factor of fibrosis. Unfortunately, the existing anti-inflammatory drugs cannot effectively prevent and alleviate fibrosis, and there is no effective anti-fibrotic drug, which makes surgical treatment the mainstream treatment for intestinal fibrosis and stenosis. Mesenchymal stem cells (MSCs) are capable of tissue regeneration and repair through their self-differentiation, secretion of cytokines, and secretion of extracellular vesicles. MSCs have been shown to play an important therapeutic role in the fibrosis of many organs. However, the role of MSC in intestinal fibrosis largely remained unexplored. This review summarizes the mechanism of intestinal fibrosis, including the role of immune cells, TGF-β, and the gut microbiome and metabolites. Available treatment options for fibrosis, particularly, MSCs are also discussed.
Author Ocansey, Dickson Kofi Wiredu
Wang, Yifei
Jin, Tao
Huang, Bin
Jiang, Jiajia
Mao, Fei
AuthorAffiliation 5 Directorate of University Health Services, University of Cape Coast , Cape Coast , Ghana
1 Aoyang Institute of Cancer, Affiliated Aoyang Hospital of Jiangsu University , Suzhou , China
4 Department of Gastrointestinal and Endoscopy, The Affiliated Yixing Hospital of Jiangsu University , Yixing , China
3 General Surgery Department, Affiliated Aoyang Hospital of Jiangsu University , Suzhou , China
2 Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University , Zhenjiang , China
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  surname: Jin
  fullname: Jin, Tao
  organization: Department of Gastrointestinal and Endoscopy, The Affiliated Yixing Hospital of Jiangsu University, Yixing, China
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  organization: Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, China
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Keywords immune cells
IBD
MSC
intestinal fibrosis
mechanism
therapy
Language English
License Copyright © 2022 Wang, Huang, Jin, Ocansey, Jiang and Mao.
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This article was submitted to Alloimmunity and Transplantation, a section of the journal Frontiers in Immunology
These authors have contributed equally to this work
Reviewed by: Johan Dabrosin Söderholm, Linköping University, Sweden; Shao-wei Li, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, China
Edited by: Hongcui Cao, Zhejiang University, China
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Snippet Intestinal fibrosis is an important complication of inflammatory bowel disease (IBD). In the course of the development of fibrosis, certain parts of the...
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SubjectTerms Fibrosis
Humans
IBD
immune cells
Immunology
Inflammatory Bowel Diseases - metabolism
intestinal fibrosis
Intestines - pathology
mechanism
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells - metabolism
MSC
Quality of Life
therapy
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Title Intestinal Fibrosis in Inflammatory Bowel Disease and the Prospects of Mesenchymal Stem Cell Therapy
URI https://www.ncbi.nlm.nih.gov/pubmed/35370998
https://search.proquest.com/docview/2646942310
https://pubmed.ncbi.nlm.nih.gov/PMC8971815
https://doaj.org/article/ecd47c709bcd4435bc9601f96e927bfd
Volume 13
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