In vivo Pharmacokinetic and Pharmacodynamic (PK/PD) Modeling and Establishment of the PK/PD Cutoff of Florfenicol Against Pasteurella multocida in Ducks

• Published in: Frontiers in microbiology Vol. 11; p. 616685
• Main Authors: Xiao, Xia, Lan, Weixuan, Zhao, Yaqin, Li, Ruichao, Liu, Yuan, Liu, Juan, Wang, Zhiqiang
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 11.01.2021
• Subjects: dose; florfenicol; Microbiology; P. multocida; PK/PD cutoff; PK/PD modeling; PK/PD modeling; dose; P. multocida; florfenicol; PK/PD cutoff

can invade and translocate through endothelial cells and result in vascular-system infection, which can cause severe economic losses in the poultry industry. Antibacterial therapy (especially florfenicol) plays an important part in controlling infection. To preserve the effect of florfenicol, pharma...