Posttranscriptional Gene Regulatory Networks in Chronic Airway Inflammatory Diseases: In silico Mapping of RNA-Binding Protein Expression in Airway Epithelium

• Published in: Frontiers in immunology Vol. 11; p. 579889
• Main Authors: Ricciardi, Luca, Giurato, Giorgio, Memoli, Domenico, Pietrafesa, Mariagrazia, Dal Col, Jessica, Salvato, Ilaria, Nigro, Annunziata, Vatrella, Alessandro, Caramori, Gaetano, Casolaro, Vincenzo, Stellato, Cristiana
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 16.10.2020
• Subjects: airway epithelium; chronic inflammation; COPD; Immunology; posttranscriptional gene regulation; RNA binding proteins; severe asthma; severe asthma; posttranscriptional gene regulation; chronic inflammation; airway epithelium; COPD; RNA binding proteins
• ISSN: 1664-3224; 1664-3224
• DOI: 10.3389/fimmu.2020.579889

Posttranscriptional gene regulation (PTGR) contributes to inflammation through alterations in messenger RNA (mRNA) turnover and translation rates. RNA-binding proteins (RBPs) coordinate these processes but their role in lung inflammatory diseases is ill-defined. We evaluated the expression of a cura...