IL-10 Enhances Human Natural Killer Cell Effector Functions via Metabolic Reprogramming Regulated by mTORC1 Signaling

• Published in: Frontiers in immunology Vol. 12; p. 619195
• Main Authors: Wang, Zixi, Guan, Di, Huo, Jianxin, Biswas, Subhra K, Huang, Yuhan, Yang, Yuansheng, Xu, Shengli, Lam, Kong-Peng
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 23.02.2021
• Subjects: cytotoxicity; IFN-γ; IL-10; Immunology; metabolism; mTOR; NK cell; mTOR; IFN-γ; metabolism; IL-10; cytotoxicity; NK cell

Cell metabolism plays a pivotal role in regulating the effector functions of immune cells. Stimulatory cytokines, such as interleukin (IL)-2 or IL-12 and IL-15, activate glycolysis and oxidative phosphorylation in natural killer (NK) cells to support their enhanced effector functions. IL-10, a pleio...