Arachidonic Acid in Adipose Tissue Is Associated with Nonfatal Acute Myocardial Infarction in the Central Valley of Costa Rica

• Published in: The Journal of nutrition Vol. 134; no. 11; pp. 3095 - 3099
• Main Authors: Baylin, Ana, Campos, Hannia
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.11.2004; American Society for Nutritional Sciences
• Subjects: adipose tissue; Adipose Tissue - chemistry; administration & dosage; age; Age Factors; Aged; analysis; arachidonic acid; Arachidonic Acid - analysis; atherogenesis; Biological and medical sciences; Body Size; Body Weight; chemistry; Chromatography, Gas; Costa Rica; Costa Rica - epidemiology; Diabetes Mellitus; Diabetes Mellitus - metabolism; Diet; Dietary Fats, Unsaturated; Dietary Fats, Unsaturated - administration & dosage; epidemiological studies; epidemiology; fat intake; fatty acids; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Humans; Hypertension; Hypertension - metabolism; linoleic acid; Linoleic Acid - administration & dosage; Linoleic Acid - analysis; linolenic acid; Logistic Models; Male; men; metabolism; Middle Aged; myocardial infarction; Myocardial Infarction - epidemiology; Myocardial Infarction - metabolism; Odds Ratio; omega-3 fatty acids; omega-6 fatty acids; Risk Factors; Sex Factors; sociodemographic characteristics; trans fatty acids; Vertebrates: anatomy and physiology, studies on body, several organs or systems; women; Costa Rica; arachidonic acid; AA; risk factors; fatty acids; myocardial infarction; adipose tissue; FA; MI; CHD; Myocardial infarction; Adipose tissue; Nutrition; Acute; Polyunsaturated fatty acid; Cardiovascular disease; Lipids; Arachidonic acid; Myocardial disease; Fatty acids; n-6 fatty acid; Heart disease; Risk factor; Unsaturated fatty acid
• DOI: 10.1093/jn/134.11.3095
• ISSN: 0022-3166

Arachidonic acid (AA), a precursor of prothrombotic eicosanoids, is potentially atherogenic, but epidemiologic data are scarce. We evaluated the hypothesis that increased AA in adipose tissue is associated with increased risk of nonfatal acute myocardial infarction (MI), and if so, whether this association is related to dietary or adipose tissue linoleic acid. We studied the association between AA and MI in 466 cases of a first nonfatal acute MI, matched on age, gender, and residence to 466 population controls. Fatty acids (FA) were assessed by GC in adipose tissue samples collected from all subjects. Odds ratios (OR) and 95% CI were calculated from multivariate conditional logistic regression models. Subjects in the highest quintile of adipose tissue AA (0.64% of total FA) had a higher risk of nonfatal acute MI than those in the lowest quintile (0.29% of total FA), after adjusting for potential confounders including (n-3) and trans FAs (OR = 1.94, 95% CI: 1.07, 3.53, P for trend = 0.026). Adipose tissue AA was not correlated with dietary AA (r = 0.07), linoleic acid (r = 0.04), or other dietary (n-6) FAs, or with adipose tissue linoleic acid (r = −0.07). These data suggest that the association between MI and adipose tissue AA is not related to dietary intake of (n-6) FAs including linoleic acid. Better understanding of the metabolic factors that increase AA in adipose tissue is urgently needed.