Molecular structure and function of big calcium-activated potassium channels in skeletal muscle: pharmacological perspectives

• Published in: Physiological genomics Vol. 49; no. 6; pp. 306 - 317
• Main Authors: Maqoud, Fatima, Cetrone, Michela, Mele, Antonietta, Tricarico, Domenico
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.06.2017
• Subjects: Alternative splicing; Alternative Splicing - genetics; Alternative Splicing - physiology; Animals; Calcium (intracellular); Calcium channels; Calcium conductance; Channel gating; Cyclic AMP-Dependent Protein Kinases - genetics; Cyclic AMP-Dependent Protein Kinases - metabolism; Cytoplasm - genetics; Cytoplasm - metabolism; Drug delivery; Drug development; HEK293 Cells; Humans; Hyperkalemia; Hypokalemia; Intracellular; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - genetics; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - metabolism; Large-Conductance Calcium-Activated Potassium Channels - genetics; Large-Conductance Calcium-Activated Potassium Channels - metabolism; Mammalian cells; MCF-7 Cells; Metabolites; Mice; Models, Biological; Molecular Structure; Muscle, Skeletal - metabolism; Musculoskeletal system; Paralysis; Potassium; Potassium channels; Potassium channels (calcium-gated); Potassium conductance; Protein interaction; Skeletal muscle; Structure-function relationships; splicing mechanism; sarcolemma BK channel; potassium channel openers; neuromuscular disorders

The large-conductance Ca 2+ -activated K + (BK) channel is broadly expressed in various mammalian cells and tissues such as neurons, skeletal muscles (sarco-BK), and smooth muscles. These channels are activated by changes in membrane electrical potential and by increases in the concentration of intr...