Dose optimization of β-lactams antibiotics in pediatrics and adults: A systematic review

Background: β-lactams remain the cornerstone of the empirical therapy to treat various bacterial infections. This systematic review aimed to analyze the data describing the dosing regimen of β-lactams. Methods: Systematic scientific and grey literature was performed in accordance with Preferred Item...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in pharmacology Vol. 13; p. 964005
Main Authors Haseeb, Abdul, Faidah, Hani Saleh, Alghamdi, Saleh, Alotaibi, Amal F., Elrggal, Mahmoud Essam, Mahrous, Ahmad J., Abuhussain, Safa S. Almarzoky, Obaid, Najla A., Algethamy, Manal, AlQarni, Abdullmoin, Khogeer, Asim A., Saleem, Zikria, Iqbal, Muhammad Shahid, Ashgar, Sami S., Radwan, Rozan Mohammad, Mutlaq, Alaa, Fatani, Nayyra, Sheikh, Aziz
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 21.09.2022
Subjects
beta-Lactams
carbapenems
cephalosporins
dose optimization
penicillins
Pharmacology
carbapenems
beta-Lactams
dose optimization
cephalosporins
penicillins
Online AccessGet full text

Cover

Abstract Background: β-lactams remain the cornerstone of the empirical therapy to treat various bacterial infections. This systematic review aimed to analyze the data describing the dosing regimen of β-lactams. Methods: Systematic scientific and grey literature was performed in accordance with Preferred Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The studies were retrieved and screened on the basis of pre-defined exclusion and inclusion criteria. The cohort studies, randomized controlled trials (RCT) and case reports that reported the dosing schedule of β-lactams are included in this study. Results: A total of 52 studies met the inclusion criteria, of which 40 were cohort studies, 2 were case reports and 10 were RCTs. The majority of the studies (34/52) studied the pharmacokinetic (PK) parameters of a drug. A total of 20 studies proposed dosing schedule in pediatrics while 32 studies proposed dosing regimen among adults. Piperacillin (12/52) and Meropenem (11/52) were the most commonly used β-lactams used in hospitalized patients. As per available evidence, continuous infusion is considered as the most appropriate mode of administration to optimize the safety and efficacy of the treatment and improve the clinical outcomes. Conclusion: Appropriate antibiotic therapy is challenging due to pathophysiological changes among different age groups. The optimization of pharmacokinetic/pharmacodynamic parameters is useful to support alternative dosing regimens such as an increase in dosing interval, continuous infusion, and increased bolus doses.
AbstractList β-lactams remain the cornerstone of the empirical therapy to treat various bacterial infections. This systematic review aimed to analyze the data describing the dosing regimen of β-lactams. Systematic scientific and grey literature was performed in accordance with Preferred Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The studies were retrieved and screened on the basis of pre-defined exclusion and inclusion criteria. The cohort studies, randomized controlled trials (RCT) and case reports that reported the dosing schedule of β-lactams are included in this study. A total of 52 studies met the inclusion criteria, of which 40 were cohort studies, 2 were case reports and 10 were RCTs. The majority of the studies (34/52) studied the pharmacokinetic (PK) parameters of a drug. A total of 20 studies proposed dosing schedule in pediatrics while 32 studies proposed dosing regimen among adults. Piperacillin (12/52) and Meropenem (11/52) were the most commonly used β-lactams used in hospitalized patients. As per available evidence, continuous infusion is considered as the most appropriate mode of administration to optimize the safety and efficacy of the treatment and improve the clinical outcomes. Appropriate antibiotic therapy is challenging due to pathophysiological changes among different age groups. The optimization of pharmacokinetic/pharmacodynamic parameters is useful to support alternative dosing regimens such as an increase in dosing interval, continuous infusion, and increased bolus doses.
Background: β-lactams remain the cornerstone of the empirical therapy to treat various bacterial infections. This systematic review aimed to analyze the data describing the dosing regimen of β-lactams. Methods: Systematic scientific and grey literature was performed in accordance with Preferred Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The studies were retrieved and screened on the basis of pre-defined exclusion and inclusion criteria. The cohort studies, randomized controlled trials (RCT) and case reports that reported the dosing schedule of β-lactams are included in this study. Results: A total of 52 studies met the inclusion criteria, of which 40 were cohort studies, 2 were case reports and 10 were RCTs. The majority of the studies (34/52) studied the pharmacokinetic (PK) parameters of a drug. A total of 20 studies proposed dosing schedule in pediatrics while 32 studies proposed dosing regimen among adults. Piperacillin (12/52) and Meropenem (11/52) were the most commonly used β-lactams used in hospitalized patients. As per available evidence, continuous infusion is considered as the most appropriate mode of administration to optimize the safety and efficacy of the treatment and improve the clinical outcomes. Conclusion: Appropriate antibiotic therapy is challenging due to pathophysiological changes among different age groups. The optimization of pharmacokinetic/pharmacodynamic parameters is useful to support alternative dosing regimens such as an increase in dosing interval, continuous infusion, and increased bolus doses.
Background: β-lactams remain the cornerstone of the empirical therapy to treat various bacterial infections. This systematic review aimed to analyze the data describing the dosing regimen of β-lactams. Methods: Systematic scientific and grey literature was performed in accordance with Preferred Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The studies were retrieved and screened on the basis of pre-defined exclusion and inclusion criteria. The cohort studies, randomized controlled trials (RCT) and case reports that reported the dosing schedule of β-lactams are included in this study. Results: A total of 52 studies met the inclusion criteria, of which 40 were cohort studies, 2 were case reports and 10 were RCTs. The majority of the studies (34/52) studied the pharmacokinetic (PK) parameters of a drug. A total of 20 studies proposed dosing schedule in pediatrics while 32 studies proposed dosing regimen among adults. Piperacillin (12/52) and Meropenem (11/52) were the most commonly used β-lactams used in hospitalized patients. As per available evidence, continuous infusion is considered as the most appropriate mode of administration to optimize the safety and efficacy of the treatment and improve the clinical outcomes. Conclusion: Appropriate antibiotic therapy is challenging due to pathophysiological changes among different age groups. The optimization of pharmacokinetic/pharmacodynamic parameters is useful to support alternative dosing regimens such as an increase in dosing interval, continuous infusion, and increased bolus doses.Background: β-lactams remain the cornerstone of the empirical therapy to treat various bacterial infections. This systematic review aimed to analyze the data describing the dosing regimen of β-lactams. Methods: Systematic scientific and grey literature was performed in accordance with Preferred Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The studies were retrieved and screened on the basis of pre-defined exclusion and inclusion criteria. The cohort studies, randomized controlled trials (RCT) and case reports that reported the dosing schedule of β-lactams are included in this study. Results: A total of 52 studies met the inclusion criteria, of which 40 were cohort studies, 2 were case reports and 10 were RCTs. The majority of the studies (34/52) studied the pharmacokinetic (PK) parameters of a drug. A total of 20 studies proposed dosing schedule in pediatrics while 32 studies proposed dosing regimen among adults. Piperacillin (12/52) and Meropenem (11/52) were the most commonly used β-lactams used in hospitalized patients. As per available evidence, continuous infusion is considered as the most appropriate mode of administration to optimize the safety and efficacy of the treatment and improve the clinical outcomes. Conclusion: Appropriate antibiotic therapy is challenging due to pathophysiological changes among different age groups. The optimization of pharmacokinetic/pharmacodynamic parameters is useful to support alternative dosing regimens such as an increase in dosing interval, continuous infusion, and increased bolus doses.
Background: β-lactams remain the cornerstone of the empirical therapy to treat various bacterial infections. This systematic review aimed to analyze the data describing the dosing regimen of β-lactams.Methods: Systematic scientific and grey literature was performed in accordance with Preferred Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The studies were retrieved and screened on the basis of pre-defined exclusion and inclusion criteria. The cohort studies, randomized controlled trials (RCT) and case reports that reported the dosing schedule of β-lactams are included in this study.Results: A total of 52 studies met the inclusion criteria, of which 40 were cohort studies, 2 were case reports and 10 were RCTs. The majority of the studies (34/52) studied the pharmacokinetic (PK) parameters of a drug. A total of 20 studies proposed dosing schedule in pediatrics while 32 studies proposed dosing regimen among adults. Piperacillin (12/52) and Meropenem (11/52) were the most commonly used β-lactams used in hospitalized patients. As per available evidence, continuous infusion is considered as the most appropriate mode of administration to optimize the safety and efficacy of the treatment and improve the clinical outcomes.Conclusion: Appropriate antibiotic therapy is challenging due to pathophysiological changes among different age groups. The optimization of pharmacokinetic/pharmacodynamic parameters is useful to support alternative dosing regimens such as an increase in dosing interval, continuous infusion, and increased bolus doses.
Author Obaid, Najla A.
Radwan, Rozan Mohammad
Alghamdi, Saleh
Faidah, Hani Saleh
Mutlaq, Alaa
Abuhussain, Safa S. Almarzoky
Algethamy, Manal
Elrggal, Mahmoud Essam
Fatani, Nayyra
Saleem, Zikria
AlQarni, Abdullmoin
Ashgar, Sami S.
Mahrous, Ahmad J.
Iqbal, Muhammad Shahid
Khogeer, Asim A.
Sheikh, Aziz
Haseeb, Abdul
Alotaibi, Amal F.
AuthorAffiliation 9 Department of Pharmacy Practice , Faculty of Pharmacy , Bahauddin Zakariya Univrsity , Multan , Pakistan
11 Pharmaceutical Care Department , Alnoor Specialist Hospital , Ministry of Health , Makkah , Saudi Arabia
4 Department of Pharmaceutics , College of Pharmacy , Umm Al-Qura University , Makkah , Saudi Arabia
1 Department of Clinical Pharmacy , College of Pharmacy , Umm Al-Qura University , Makkah , Saudi Arabia
2 Department of Microbiology , Faculty of Medicine , Umm Al-Qura University , Makkah , Saudi Arabia
5 Department of Infection Prevention and Control Program , Alnoor Specialist Hospital , Makkah , Saudi Arabia
8 Medical Genetics Unit , Maternity and Children Hospital , Makkah Healthcare Cluster , Ministry of Health , Makkah , Saudi Arabia
13 King Abdulaziz University , Jeddah , Saudi Arabia
10 Department of Clinical Pharmacy , College of Pharmacy , Prince Sattam Bin Abdulaziz University , Al-Kharj , Saudi Arabia
7 Plan and Research Department , General Directorate of Health Affairs
AuthorAffiliation_xml – name: 9 Department of Pharmacy Practice , Faculty of Pharmacy , Bahauddin Zakariya Univrsity , Multan , Pakistan
– name: 10 Department of Clinical Pharmacy , College of Pharmacy , Prince Sattam Bin Abdulaziz University , Al-Kharj , Saudi Arabia
– name: 11 Pharmaceutical Care Department , Alnoor Specialist Hospital , Ministry of Health , Makkah , Saudi Arabia
– name: 4 Department of Pharmaceutics , College of Pharmacy , Umm Al-Qura University , Makkah , Saudi Arabia
– name: 3 Department of Clinical Pharmacy , Faculty of Clinical Pharmacy , Al Baha University , Al Baha , Saudi Arabia
– name: 8 Medical Genetics Unit , Maternity and Children Hospital , Makkah Healthcare Cluster , Ministry of Health , Makkah , Saudi Arabia
– name: 5 Department of Infection Prevention and Control Program , Alnoor Specialist Hospital , Makkah , Saudi Arabia
– name: 12 General Department of Pharmaceutical Care , Ministry of Health , Riyadh , Saudi Arabia
– name: 14 Usher Institute , The University of Edinburgh , Edinburgh , United Kingdom
– name: 6 Infectious Diseases Department , Alnoor Specialist Hospital , Makkah , Saudi Arabia
– name: 2 Department of Microbiology , Faculty of Medicine , Umm Al-Qura University , Makkah , Saudi Arabia
– name: 13 King Abdulaziz University , Jeddah , Saudi Arabia
– name: 1 Department of Clinical Pharmacy , College of Pharmacy , Umm Al-Qura University , Makkah , Saudi Arabia
– name: 7 Plan and Research Department , General Directorate of Health Affairs of Makkah Region , Ministry of Health , Makkah , Saudi Arabia
Author_xml – sequence: 1
  givenname: Abdul
  surname: Haseeb
  fullname: Haseeb, Abdul
– sequence: 2
  givenname: Hani Saleh
  surname: Faidah
  fullname: Faidah, Hani Saleh
– sequence: 3
  givenname: Saleh
  surname: Alghamdi
  fullname: Alghamdi, Saleh
– sequence: 4
  givenname: Amal F.
  surname: Alotaibi
  fullname: Alotaibi, Amal F.
– sequence: 5
  givenname: Mahmoud Essam
  surname: Elrggal
  fullname: Elrggal, Mahmoud Essam
– sequence: 6
  givenname: Ahmad J.
  surname: Mahrous
  fullname: Mahrous, Ahmad J.
– sequence: 7
  givenname: Safa S. Almarzoky
  surname: Abuhussain
  fullname: Abuhussain, Safa S. Almarzoky
– sequence: 8
  givenname: Najla A.
  surname: Obaid
  fullname: Obaid, Najla A.
– sequence: 9
  givenname: Manal
  surname: Algethamy
  fullname: Algethamy, Manal
– sequence: 10
  givenname: Abdullmoin
  surname: AlQarni
  fullname: AlQarni, Abdullmoin
– sequence: 11
  givenname: Asim A.
  surname: Khogeer
  fullname: Khogeer, Asim A.
– sequence: 12
  givenname: Zikria
  surname: Saleem
  fullname: Saleem, Zikria
– sequence: 13
  givenname: Muhammad Shahid
  surname: Iqbal
  fullname: Iqbal, Muhammad Shahid
– sequence: 14
  givenname: Sami S.
  surname: Ashgar
  fullname: Ashgar, Sami S.
– sequence: 15
  givenname: Rozan Mohammad
  surname: Radwan
  fullname: Radwan, Rozan Mohammad
– sequence: 16
  givenname: Alaa
  surname: Mutlaq
  fullname: Mutlaq, Alaa
– sequence: 17
  givenname: Nayyra
  surname: Fatani
  fullname: Fatani, Nayyra
– sequence: 18
  givenname: Aziz
  surname: Sheikh
  fullname: Sheikh, Aziz
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36210807$$D View this record in MEDLINE/PubMed
BookMark eNp9kstu1TAQhiNUREvpA7BBWbLJwdc4YYFUlVulSmxgwcqa2OPWVRIH26dVeSwepM9Un3NK1bLAG3vsf74Za_6X1d4cZqyq15SsOO_6d265gLhihLFV3wpC5LPqgLYtb_qOsr1H5_3qKKVLUhbve96KF9U-bxklHVEH1c-PIWEdluwn_xuyD3MdXH37pxnBZJhSDXP2gw_Zm1T7uV7QeshxE8Fsa7DrMaf39XGdblLGqRBMHfHK4_Wr6rmDMeHR_X5Y_fj86fvJ1-bs25fTk-OzxohW5gakRNYah5wj6ZVRVHZMdIOkFhxF5YCQwUkl1SCd4gaU4EJ0zlFoRS8JP6xOd1wb4FIv0U8Qb3QAr7cXIZ5riKWtETXhwiqHbrC0Fc66wQ1DbyV0BsGhsIX1Ycda1sOE1uCcI4xPoE9fZn-hz8OV7iVnvWAF8PYeEMOvNaasJ58MjiPMGNZJM8W46MrH2yJ987jWQ5G_sykCuhOYGFKK6B4klOiNBfTWAnpjAb2zQMlR_-QYn7djLe368T-ZdyaKumY
CitedBy_id crossref_primary_10_3390_foods14020253
crossref_primary_10_1080_14787210_2024_2406466
crossref_primary_10_1016_j_ejps_2024_106859
crossref_primary_10_1016_j_jpp_2024_02_002
crossref_primary_10_1016_j_idnow_2023_104781
crossref_primary_10_1016_j_pedneo_2023_09_008
Cites_doi 10.1592/phco.28.6.691
10.1007/s40262-017-0602-9
10.1007/s40262-018-0682-1
10.1248/bpb.31.316
10.1007/s00134-013-3187-2
10.1128/AAC.00182-11
10.1097/ipc.0b013e31822e9bf5
10.1093/jac/dku465
10.3390/antibiotics11030409
10.1016/j.clinthera.2016.06.015
10.1016/j.jiac.2017.09.005
10.1002/phar.1567
10.1016/j.medin.2015.07.009
10.1093/cid/cis857
10.1002/jac5.1084
10.1016/j.diagmicrobio.2007.03.015
10.1007/s11096-016-0286-5
10.1016/s0924-8579(01)00329-6
10.1007/s00228-018-02606-9
10.1097/pcc.0000000000001497
10.1128/AAC.00249-20
10.1093/ofid/ofz067
10.1093/jac/dkx093
10.3389/fphar.2020.00620
10.1007/s40262-019-00813-w
10.1016/j.jsps.2020.08.005
10.1128/AAC.04232-14
10.1093/infdis/159.2.281
10.1128/AAC.02089-15
10.1002/jcph.1752
10.1016/j.chest.2019.01.013
10.1128/AAC.41.9.2053
10.3389/fphar.2020.00551
10.3389/fphar.2020.570238
10.1093/jac/47.4.421
10.1093/jac/dkf130
10.1016/S1473-3099(14)70036-2
10.1186/1471-2334-7-21
10.1007/s11908-018-0613-1
10.1128/CMR.00022-16
10.1093/cid/ciu542
10.1093/jac/dkx427
10.1080/14787210.2017.1338139
10.1186/s40779-020-00238-8
10.1097/MCC.0b013e3282e2a98f
10.1016/s0002-9610(00)00388-3
10.1136/bmjgh-2020-003393
10.1093/jac/dkl478
10.1186/2046-4053-4-1
10.1007/s00134-022-06679-0
10.1128/AAC.02336-18
10.3389/fped.2021.624639
10.1186/s13054-014-0480-6
10.1128/AAC.00521-12
10.1128/aac.01318-06
10.1248/bpb.32.1139
10.1111/j.1365-2125.2011.04117.x
10.1186/s13054-019-2378-9
10.1086/510590
10.1128/AAC.02042-17
10.1345/aph.1G467
10.1186/2047-2994-3-33
10.1016/j.diagmicrobio.2004.08.019
10.3390/antibiotics9020065
10.5863/1551-6776-22.6.467
10.1345/aph.1S032
10.1186/cc8941
10.1186/s12879-019-4245-3
10.1093/jac/dku195
10.1371/journal.pone.0149623
10.2165/00003495-200565170-00006
10.2147/idr.s10018
10.1128/AAC.45.9.2436-2440.2001
10.3390/antibiotics10121454
10.1016/j.cmi.2015.05.002
10.1128/aac.01368-15
10.1097/01.pcc.0000538117.18545.8d
10.3389/fphar.2020.521933
10.1016/j.rmclc.2016.08.001
10.1248/bpb.b15-00334
10.1016/j.jiph.2019.07.003
10.1093/jac/dkv123
10.1093/jac/dky574
10.1007/s00134-010-2105-0
10.1007/s40121-016-0139-5
10.1128/AAC.01183-09
10.7860/JCDR/2013/5239.3052
10.1016/s0924-8579(02)00022-5
10.1007/s10096-019-03535-w
10.1093/cid/cis856
10.1128/AAC.48.5.1713-1718.2004
10.3390/antibiotics9100676
10.1016/j.ijantimicag.2008.10.025
10.1093/jac/dkw496
10.1016/s0924-8579(02)00027-4
10.3390/antibiotics10030280
10.1128/AAC.00997-16
10.1592/phco.31.8.767
10.5863/1551-6776-22.4.276
10.1093/jac/dkr137
10.1097/INF.0b013e3182a743c7
10.1016/j.ijantimicag.2009.10.008
10.1007/s00228-020-02939-4
10.1093/jac/49.1.121
10.1186/s13613-019-0622-8
10.1128/AAC.01149-05
10.1016/j.clinthera.2007.11.003
ContentType Journal Article
Copyright Copyright © 2022 Haseeb, Faidah, Alghamdi, Alotaibi, Elrggal, Mahrous, Abuhussain, Obaid, Algethamy, AlQarni, Khogeer, Saleem, Iqbal, Ashgar, Radwan, Mutlaq, Fatani and Sheikh.
Copyright © 2022 Haseeb, Faidah, Alghamdi, Alotaibi, Elrggal, Mahrous, Abuhussain, Obaid, Algethamy, AlQarni, Khogeer, Saleem, Iqbal, Ashgar, Radwan, Mutlaq, Fatani and Sheikh. 2022 Haseeb, Faidah, Alghamdi, Alotaibi, Elrggal, Mahrous, Abuhussain, Obaid, Algethamy, AlQarni, Khogeer, Saleem, Iqbal, Ashgar, Radwan, Mutlaq, Fatani and Sheikh
Copyright_xml – notice: Copyright © 2022 Haseeb, Faidah, Alghamdi, Alotaibi, Elrggal, Mahrous, Abuhussain, Obaid, Algethamy, AlQarni, Khogeer, Saleem, Iqbal, Ashgar, Radwan, Mutlaq, Fatani and Sheikh.
– notice: Copyright © 2022 Haseeb, Faidah, Alghamdi, Alotaibi, Elrggal, Mahrous, Abuhussain, Obaid, Algethamy, AlQarni, Khogeer, Saleem, Iqbal, Ashgar, Radwan, Mutlaq, Fatani and Sheikh. 2022 Haseeb, Faidah, Alghamdi, Alotaibi, Elrggal, Mahrous, Abuhussain, Obaid, Algethamy, AlQarni, Khogeer, Saleem, Iqbal, Ashgar, Radwan, Mutlaq, Fatani and Sheikh
DBID AAYXX
CITATION
NPM
7X8
5PM
DOA
DOI 10.3389/fphar.2022.964005
DatabaseName CrossRef
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
DatabaseTitleList PubMed

MEDLINE - Academic

CrossRef
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Pharmacy, Therapeutics, & Pharmacology
DocumentTitleAlternate Haseeb et al
EISSN 1663-9812
ExternalDocumentID oai_doaj_org_article_034d7fefbd164fdfbfbb9d5a8ceafe4d
PMC9532942
36210807
10_3389_fphar_2022_964005
Genre Systematic Review
GrantInformation_xml – fundername: ;
GroupedDBID 53G
5VS
9T4
AAFWJ
AAKDD
AAYXX
ACGFO
ACGFS
ACXDI
ADBBV
ADRAZ
AENEX
AFPKN
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BCNDV
CITATION
DIK
EMOBN
GROUPED_DOAJ
GX1
HYE
KQ8
M48
M~E
O5R
O5S
OK1
P2P
PGMZT
RNS
RPM
IPNFZ
NPM
RIG
7X8
5PM
ID FETCH-LOGICAL-c465t-a55e26cfe33e097c7158248b51daf1e7fa00bf5757b5f73ca743448ff1a649503
IEDL.DBID M48
ISSN 1663-9812
IngestDate Wed Aug 27 01:20:14 EDT 2025
Thu Aug 21 18:39:57 EDT 2025
Thu Jul 10 19:04:00 EDT 2025
Thu Apr 03 07:07:14 EDT 2025
Tue Jul 01 02:33:43 EDT 2025
Thu Apr 24 23:03:21 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords carbapenems
beta-Lactams
dose optimization
cephalosporins
penicillins
Language English
License Copyright © 2022 Haseeb, Faidah, Alghamdi, Alotaibi, Elrggal, Mahrous, Abuhussain, Obaid, Algethamy, AlQarni, Khogeer, Saleem, Iqbal, Ashgar, Radwan, Mutlaq, Fatani and Sheikh.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c465t-a55e26cfe33e097c7158248b51daf1e7fa00bf5757b5f73ca743448ff1a649503
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Undefined-1
ObjectType-Feature-3
content type line 23
This article was submitted to Pharmacology of Infectious Diseases, a section of the journal Frontiers in Pharmacology
Reviewed by: Alan Abdulla, Erasmus Medical Center, Netherlands
Edited by: Jessica K. Roberts, Cognigen, United States
Muhammad Usman, University of Veterinary and Animal Sciences, Pakistan
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.3389/fphar.2022.964005
PMID 36210807
PQID 2723484656
PQPubID 23479
ParticipantIDs doaj_primary_oai_doaj_org_article_034d7fefbd164fdfbfbb9d5a8ceafe4d
pubmedcentral_primary_oai_pubmedcentral_nih_gov_9532942
proquest_miscellaneous_2723484656
pubmed_primary_36210807
crossref_primary_10_3389_fphar_2022_964005
crossref_citationtrail_10_3389_fphar_2022_964005
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2022-09-21
PublicationDateYYYYMMDD 2022-09-21
PublicationDate_xml – month: 09
  year: 2022
  text: 2022-09-21
  day: 21
PublicationDecade 2020
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
PublicationTitle Frontiers in pharmacology
PublicationTitleAlternate Front Pharmacol
PublicationYear 2022
Publisher Frontiers Media S.A
Publisher_xml – name: Frontiers Media S.A
References Lesprit (B69) 2008; 21
Cheatham (B13) 2008; 28
Cies (B15); 19
Crandon (B23) 2011; 37
Moher (B83) 2015; 4
De Cock (B27) 2015; 59
Sime (B104); 21
Masich (B81); 20
Neely (B87) 2018; 62
Luyt (B76) 2014; 18
De Cock (B28) 2017; 72
Nielsen (B90) 2011; 55
Gijsen (B41) 2022; 48
Haseeb (B51) 2020; 28
Dow (B32); 19
Hanes (B47) 2000; 179
Delattre (B31) 2017; 15
Sulis (B105) 2020; 5
Felton (B36) 2012; 56
Cies (B19) 2019; 74
Pickens (B96) 2019; 156
Higgins (B55) 2019
Masich (B80); 20
Tam (B106) 2002; 50
Joynt (B57) 2001; 47
Gross (B42) 2019
Gustafsson (B45) 2001; 45
Yokoyama (B117) 2018; 24
Buijk (B9) 2002; 49
Haseeb (B50) 2022; 11
He (B54) 2020
Lodise (B70); 44
Cies (B18) 2015; 35
Owens (B93) 2005; 51
Mouton (B85) 2004; 48
Cies (B16); 22
Lodise (B71); 58
Roberts (B98) 2014; 14
Atif (B5) 2020; 13
Shah (B102) 2013; 38
Xu (B114) 2019; 75
Grupper (B43) 2016; 29
Hammond (B46) 2019; 2
Mouton (B86) 2007; 13
Onufrak (B92) 2016; 38
Guilhaumou (B44) 2019; 23
Olguin (B91) 2008; 31
Lee (B67) 2017; 6
Kasiakou (B61) 2005; 65
Cies (B14); 22
Hsaiky (B56) 2013; 47
Laterre (B66) 2015; 70
Nichols (B88) 2016; 60
Haseeb (B53); 10
Thakuria (B109) 2013; 7
Abdulla (B1) 2021; 9
Béranger (B6) 2019; 58
Georges (B39) 2012; 73
Cies (B17); 19
Tan (B107) 2018; 19
Alghamdi (B3) 2021; 10
Lorente (B73) 2007; 29
Khan (B62) 2016; 11
Roberts (B99) 2007; 59
Mettler (B82) 2007; 7
Wu (B113) 2021; 61
Kaki (B58) 2011; 66
MacGowan (B78) 2002; 19
Hartman (B49) 2020; 59
Sakka (B101) 2007; 51
Béranger (B7) 2018; 57
Crandon (B24) 2010; 54
Khan (B63) 2020; 76
Pollack (B97) 2014; 59
Kuti (B65) 2016; 27
Manduru (B79) 1997; 41
Tang (B108) 2019; 63
Sime (B103); 70
Lu (B75) 2016; 60
Cotta (B21) 2015; 39
Hartman (B48) 2019; 38
Pacios (B94) 2020; 9
D’Agate (B25) 2020; 11
Dow (B33)
Haseeb (B52); 11
Andes (B4) 2002; 19
Lorente (B72) 2009; 33
van Limburg (B110) 2014; 3
De Waele (B29); 80
Ma (B77) 2020; 7
Pandey (B95) 2020
Yokoyama (B116) 2016; 38
Giannoni (B40) 2006; 50
Kang (B59) 2020; 64
Kantasiripitak (B60) 2020; 11
Cies (B20) 2014; 33
Adembri (B2) 2020; 9
Frymoyer (B37) 2020; 11
Fukumoto (B38) 2009; 32
Chapuis (B12) 2010; 14
Yost (B118) 2011; 31
Falagas (B35) 2013; 56
Leggett (B68) 1989; 159
Wangai (B111) 2019; 19
De Waele (B30); 40
Kothekar (B64) 2020; 10
De Cock (B26) 2016; 72
Cousson (B22) 2015; 59
Dulhunty (B34) 2013; 56
Caron (B11) 2010; 3
Yokoyama (B115) 2015; 38
Nicolau (B89) 2001; 17
Wells (B112) 2014
Bozcal (B8) 2017
Lorente (B74) 2006; 40
Roberts (B100) 2010; 35
Carlier (B10) 2014; 69
Mouton (B84) 2018; 73
References_xml – volume: 28
  start-page: 691
  year: 2008
  ident: B13
  article-title: Steady‐state pharmacokinetics and pharmacodynamics of meropenem in hospitalized patients
  publication-title: Pharmacotherapy
  doi: 10.1592/phco.28.6.691
– volume-title: Beta lactam antibiotics
  year: 2020
  ident: B95
– volume: 57
  start-page: 867
  year: 2018
  ident: B7
  article-title: Population pharmacokinetic model to optimize cefotaxime dosing regimen in critically ill children
  publication-title: Clin. Pharmacokinet.
  doi: 10.1007/s40262-017-0602-9
– volume: 58
  start-page: 223
  year: 2019
  ident: B6
  article-title: Piperacillin population pharmacokinetics and dosing regimen optimization in critically ill children with normal and augmented renal clearance
  publication-title: Clin. Pharmacokinet.
  doi: 10.1007/s40262-018-0682-1
– volume: 31
  start-page: 316
  year: 2008
  ident: B91
  article-title: Effect of severity disease on the pharmacokinetics of cefuroxime in children with multiple organ system failure
  publication-title: Biol. Pharm. Bull.
  doi: 10.1248/bpb.31.316
– volume: 40
  start-page: 380
  ident: B30
  article-title: Therapeutic drug monitoring-based dose optimisation of piperacillin and meropenem: A randomised controlled trial
  publication-title: Intensive Care Med.
  doi: 10.1007/s00134-013-3187-2
– volume: 55
  start-page: 4619
  year: 2011
  ident: B90
  article-title: Pharmacokinetic/pharmacodynamic (PK/PD) indices of antibiotics predicted by a semimechanistic PKPD model: A step toward model-based dose optimization
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.00182-11
– volume: 19
  start-page: 413
  ident: B32
  article-title: Retrospective study of prolonged versus intermittent infusion piperacillin-tazobactam and meropenem in intensive care unit patients at an academic medical center
  publication-title: Infect. Dis. Clin. Pract. Balt. Md.
  doi: 10.1097/ipc.0b013e31822e9bf5
– volume: 70
  start-page: 891
  year: 2015
  ident: B66
  article-title: Temocillin (6 g daily) in critically ill patients: Continuous infusion versus three times daily administration
  publication-title: J. Antimicrob. Chemother.
  doi: 10.1093/jac/dku465
– volume: 11
  start-page: 409
  year: 2022
  ident: B50
  article-title: A systematic review on clinical safety and efficacy of vancomycin loading dose in critically ill patients
  publication-title: Antibiotics
  doi: 10.3390/antibiotics11030409
– volume: 38
  start-page: 1930
  year: 2016
  ident: B92
  article-title: Pharmacokinetic and pharmacodynamic principles of anti-infective dosing
  publication-title: Clin. Ther.
  doi: 10.1016/j.clinthera.2016.06.015
– volume: 24
  start-page: 92
  year: 2018
  ident: B117
  article-title: Dosing optimization of meropenem based on a pharmacokinetic analysis in patients receiving hemodiafiltration and an in vitro model
  publication-title: J. Infect. Chemother.
  doi: 10.1016/j.jiac.2017.09.005
– volume: 35
  start-page: e32
  year: 2015
  ident: B18
  article-title: Pharmacokinetics of continuous-infusion meropenem for the treatment of Serratia marcescens ventriculitis in a pediatric patient
  publication-title: Pharmacotherapy
  doi: 10.1002/phar.1567
– volume: 39
  start-page: 563
  year: 2015
  ident: B21
  article-title: Antibiotic dose optimization in critically ill patients
  publication-title: Med. Intensiva
  doi: 10.1016/j.medin.2015.07.009
– volume: 56
  start-page: 272
  year: 2013
  ident: B35
  article-title: Clinical outcomes with extended or continuous versus short-term intravenous infusion of carbapenems and piperacillin/tazobactam: A systematic review and meta-analysis
  publication-title: Clin. Infect. Dis.
  doi: 10.1093/cid/cis857
– volume: 2
  start-page: 468
  year: 2019
  ident: B46
  article-title: Perceptions and practices for beta‐lactam antibiotic dosing, administration, and monitoring in critically ill patients: Current views and use among critical care and infectious diseases pharmacists
  publication-title: J. Am. Coll. Clin. Pharm.
  doi: 10.1002/jac5.1084
– volume: 58
  start-page: 445
  ident: B71
  article-title: Comparison of the probability of target attainment between ceftriaxone and cefepime in the cerebrospinal fluid and serum against Streptococcus pneumoniae
  publication-title: Diagn. Microbiol. Infect. Dis.
  doi: 10.1016/j.diagmicrobio.2007.03.015
– start-page: 205
  volume-title: Assessing risk of bias in a randomized trial
  year: 2019
  ident: B55
– volume: 38
  start-page: 771
  year: 2016
  ident: B116
  article-title: The pharmacokinetics of ampicillin–sulbactam in anuric patients: Dosing optimization for prophylaxis during cardiovascular surgery
  publication-title: Int. J. Clin. Pharm.
  doi: 10.1007/s11096-016-0286-5
– volume: 17
  start-page: 497
  year: 2001
  ident: B89
  article-title: Continuous versus intermittent administration of ceftazidime in intensive care unit patients with nosocomial pneumonia
  publication-title: Int. J. Antimicrob. Agents
  doi: 10.1016/s0924-8579(01)00329-6
– volume: 75
  start-page: 595
  year: 2019
  ident: B114
  article-title: Pharmacokinetics of meropenem in plasma and cerebrospinal fluid in patients with intraventricular hemorrhage after lateral ventricle drainage
  publication-title: Eur. J. Clin. Pharmacol.
  doi: 10.1007/s00228-018-02606-9
– volume: 19
  start-page: e292
  ident: B15
  article-title: Ceftaroline for suspected or confirmed invasive methicillin-resistant Staphylococcus aureus: A pharmacokinetic case series
  publication-title: Pediatr. Crit. Care Med.
  doi: 10.1097/pcc.0000000000001497
– volume: 19
  start-page: e292
  ident: B17
  article-title: Ceftaroline for suspected or confirmed invasive methicillin-resistant Staphylococcus aureus: A pharmacokinetic case series.
  publication-title: Pediatr. Crit. Care Med.
  doi: 10.1097/pcc.0000000000001497
– volume: 64
  start-page: e00249-20
  year: 2020
  ident: B59
  article-title: Dose optimization of cefpirome based on population pharmacokinetics and target attainment during extracorporeal membrane oxygenation
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.00249-20
– volume-title: Open forum infectious diseases
  year: 2019
  ident: B42
  article-title: Successful implementation of an antibiotic stewardship program in an academic dental practice
  doi: 10.1093/ofid/ofz067
– volume: 72
  start-page: 2002
  year: 2017
  ident: B28
  article-title: Dose optimization of piperacillin/tazobactam in critically ill children
  publication-title: J. Antimicrob. Chemother.
  doi: 10.1093/jac/dkx093
– volume: 11
  start-page: 620
  year: 2020
  ident: B60
  article-title: Software tools for model-informed precision dosing: How well do they satisfy the needs?
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2020.00620
– volume: 59
  start-page: 173
  year: 2020
  ident: B49
  article-title: Pharmacokinetics and target attainment of antibiotics in critically ill children: A systematic review of current literature
  publication-title: Clin. Pharmacokinet.
  doi: 10.1007/s40262-019-00813-w
– volume: 28
  start-page: 1166
  year: 2020
  ident: B51
  article-title: Evaluation of antimicrobial stewardship programs (ASPs) and their perceived level of success at makkah region hospitals, kingdom of Saudi arabia
  publication-title: Saudi Pharm. J.
  doi: 10.1016/j.jsps.2020.08.005
– volume: 59
  start-page: 1905
  year: 2015
  ident: B22
  article-title: Lung concentrations of ceftazidime administered by continuous versus intermittent infusion in patients with ventilator-associated pneumonia
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.04232-14
– volume: 159
  start-page: 281
  year: 1989
  ident: B68
  article-title: Comparative antibiotic dose-effect relations at several dosing intervals in murine pneumonitis and thigh-infection models
  publication-title: J. Infect. Dis.
  doi: 10.1093/infdis/159.2.281
– volume: 60
  start-page: 522
  year: 2016
  ident: B88
  article-title: Population pharmacokinetics and pharmacodynamics of extended-infusion piperacillin and tazobactam in critically ill children
  publication-title: Antimicrob. Agents Chemother.Antimicrobial Agents Chemother.
  doi: 10.1128/AAC.02089-15
– volume: 61
  start-page: 538
  year: 2021
  ident: B113
  article-title: Population pharmacokinetics and dosing optimization of amoxicillin in Chinese infants
  publication-title: J. Clin. Pharmacol.
  doi: 10.1002/jcph.1752
– volume: 156
  start-page: 163
  year: 2019
  ident: B96
  article-title: Principles and practice of antibiotic stewardship in the ICU
  publication-title: Chest
  doi: 10.1016/j.chest.2019.01.013
– volume: 41
  start-page: 2053
  year: 1997
  ident: B79
  article-title: In vitro pharmacodynamics of ceftazidime against Pseudomonas aeruginosa isolates from cystic fibrosis patients
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.41.9.2053
– volume: 11
  start-page: 551
  year: 2020
  ident: B37
  article-title: Model-informed precision dosing of vancomycin in hospitalized children: Implementation and adoption at an academic children's hospital
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2020.00551
– volume: 21
  start-page: 344
  year: 2008
  ident: B69
  publication-title: Hosp. Antibiot. Steward.
– volume: 11
  start-page: 570238
  ident: B52
  article-title: Evaluation of a multidisciplinary antimicrobial stewardship program in a Saudi critical care unit: A quasi-experimental study
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2020.570238
– volume: 47
  start-page: 421
  year: 2001
  ident: B57
  article-title: The pharmacokinetics of once-daily dosing of ceftriaxone in critically ill patients
  publication-title: J. Antimicrob. Chemother.
  doi: 10.1093/jac/47.4.421
– volume: 50
  start-page: 425
  year: 2002
  ident: B106
  article-title: Pharmacodynamics of cefepime in patients with Gram-negative infections
  publication-title: J. Antimicrob. Chemother.
  doi: 10.1093/jac/dkf130
– volume: 14
  start-page: 498
  year: 2014
  ident: B98
  article-title: Individualised antibiotic dosing for patients who are critically ill: Challenges and potential solutions
  publication-title: Lancet. Infect. Dis.
  doi: 10.1016/S1473-3099(14)70036-2
– volume: 7
  start-page: 21
  year: 2007
  ident: B82
  article-title: Empirical use of antibiotics and adjustment of empirical antibiotic therapies in a university hospital: A prospective observational study
  publication-title: BMC Infect. Dis.
  doi: 10.1186/1471-2334-7-21
– volume: 20
  start-page: 9
  ident: B81
  article-title: Pharmacokinetic/pharmacodynamic considerations of beta-lactam antibiotics in adult critically ill patients
  publication-title: Curr. Infect. Dis. Rep.
  doi: 10.1007/s11908-018-0613-1
– volume: 29
  start-page: 759
  year: 2016
  ident: B43
  article-title: Continuous and prolonged intravenous β-lactam dosing: Implications for the clinical laboratory
  publication-title: Clin. Microbiol. Rev.
  doi: 10.1128/CMR.00022-16
– volume: 59
  start-page: S97
  year: 2014
  ident: B97
  article-title: Core elements of hospital antibiotic stewardship programs from the Centers for Disease Control and Prevention
  publication-title: Clin. Infect. Dis.
  doi: 10.1093/cid/ciu542
– volume: 73
  start-page: 564
  year: 2018
  ident: B84
  article-title: MIC-Based dose adjustment: Facts and fables.
  publication-title: J. Antimicrob. Chemother.
  doi: 10.1093/jac/dkx427
– volume: 15
  start-page: 677
  year: 2017
  ident: B31
  article-title: Optimizing β-lactams treatment in critically-ill patients using pharmacokinetics/pharmacodynamics targets: Are first conventional doses effective?
  publication-title: Expert Rev. anti. Infect. Ther.
  doi: 10.1080/14787210.2017.1338139
– volume: 7
  start-page: 7
  year: 2020
  ident: B77
  article-title: Methodological quality (risk of bias) assessment tools for primary and secondary medical studies: What are they and which is better?
  publication-title: Mil. Med. Res.
  doi: 10.1186/s40779-020-00238-8
– volume-title: Newcastle-Ottawa quality assessment scale cohort studies
  year: 2014
  ident: B112
– volume: 13
  start-page: 598
  year: 2007
  ident: B86
  article-title: Continuous infusion of beta-lactams
  publication-title: Curr. Opin. Crit. Care
  doi: 10.1097/MCC.0b013e3282e2a98f
– volume: 179
  start-page: 436
  year: 2000
  ident: B47
  article-title: Intermittent and continuous ceftazidime infusion for critically ill trauma patients
  publication-title: Am. J. Surg.
  doi: 10.1016/s0002-9610(00)00388-3
– volume: 5
  start-page: e003393
  year: 2020
  ident: B105
  article-title: Antibiotic overuse in the primary health care setting: A secondary data analysis of standardised patient studies from India, China and Kenya
  publication-title: BMJ Glob. Health
  doi: 10.1136/bmjgh-2020-003393
– volume: 59
  start-page: 285
  year: 2007
  ident: B99
  article-title: Is continuous infusion ceftriaxone better than once-a-day dosing in intensive care?
  publication-title: J. Antimicrob. Chemother.
  doi: 10.1093/jac/dkl478
– volume: 4
  start-page: 1
  year: 2015
  ident: B83
  article-title: Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement
  publication-title: Syst. Rev.
  doi: 10.1186/2046-4053-4-1
– volume: 48
  start-page: 768
  year: 2022
  ident: B41
  article-title: The TARGET trial as a plea for model-informed precision dosing of piperacillin/tazobactam in patients with sepsis
  publication-title: Intensive Care Med.
  doi: 10.1007/s00134-022-06679-0
– volume: 63
  start-page: e02336-18
  year: 2019
  ident: B108
  article-title: Population pharmacokinetics and dosing optimization of amoxicillin in neonates and young infants
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.02336-18
– volume: 9
  start-page: 624639
  year: 2021
  ident: B1
  article-title: Model-informed precision dosing of antibiotics in pediatric patients: A narrative review
  publication-title: Front. Pediatr.
  doi: 10.3389/fped.2021.624639
– volume: 18
  start-page: 1
  year: 2014
  ident: B76
  article-title: Antibiotic stewardship in the intensive care unit
  publication-title: Crit. Care (Houten).
  doi: 10.1186/s13054-014-0480-6
– volume: 56
  start-page: 4087
  year: 2012
  ident: B36
  article-title: Population pharmacokinetics of extended-infusion piperacillin-tazobactam in hospitalized patients with nosocomial infections
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.00521-12
– volume: 51
  start-page: 3304
  year: 2007
  ident: B101
  article-title: Population pharmacokinetics and pharmacodynamics of continuous versus short-term infusion of imipenem-cilastatin in critically ill patients in a randomized, controlled trial
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/aac.01318-06
– volume: 32
  start-page: 1139
  year: 2009
  ident: B38
  article-title: Pharmacokinetics of ceftriaxione, a third-generation cephalosporin, in pediatric patients
  publication-title: Biol. Pharm. Bull.
  doi: 10.1248/bpb.32.1139
– volume: 73
  start-page: 588
  year: 2012
  ident: B39
  article-title: Ceftazidime dosage regimen in intensive care unit patients: From a population pharmacokinetic approach to clinical practice via Monte Carlo simulations
  publication-title: Br. J. Clin. Pharmacol.
  doi: 10.1111/j.1365-2125.2011.04117.x
– volume: 23
  start-page: 104
  year: 2019
  ident: B44
  article-title: Optimization of the treatment with beta-lactam antibiotics in critically ill patients—guidelines from the French Society of Pharmacology and Therapeutics (Société Française de Pharmacologie et Thérapeutique—SFPT) and the French Society of Anaesthesia and Intensive Care Medicine (Société Française d’Anesthésie et Réanimation—SFAR)
  publication-title: Crit. Care
  doi: 10.1186/s13054-019-2378-9
– volume: 44
  start-page: 357
  ident: B70
  article-title: Piperacillin-tazobactam for Pseudomonas aeruginosa infection: Clinical implications of an extended-infusion dosing strategy
  publication-title: Clin. Infect. Dis.
  doi: 10.1086/510590
– volume: 80
  start-page: 1302
  ident: B29
  article-title: Extended versus bolus infusion of meropenem and piperacillin: A pharmacokinetic analysis
  publication-title: Minerva Anestesiol.
– start-page: 413
  volume-title: Retrospective Study of Prolonged Versus Intermittent Infusion Piperacillin-Tazobactam and Meropenem in Intensive Care Unit Patients at an Academic Medical Center
  ident: B33
– volume: 62
  start-page: e02042-17
  year: 2018
  ident: B87
  article-title: Prospective trial on the use of trough concentration versus area under the curve to determine therapeutic vancomycin dosing
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.02042-17
– volume: 20
  start-page: 9
  ident: B80
  article-title: Pharmacokinetic/pharmacodynamic considerations of beta-lactam antibiotics in adult critically ill patients
  publication-title: Curr. Infect. Dis. Rep.
  doi: 10.1007/s11908-018-0613-1
– start-page: 87
  volume-title: Toxicity of β-lactam antibiotics: Pathophysiology, molecular biology and possible recovery strategies
  year: 2017
  ident: B8
  article-title: Simplified techniques for analysis
– volume: 40
  start-page: 219
  year: 2006
  ident: B74
  article-title: Meropenem by continuous versus intermittent infusion in ventilator-associated pneumonia due to gram-negative bacilli
  publication-title: Ann. Pharmacother.
  doi: 10.1345/aph.1G467
– volume: 3
  start-page: 33
  year: 2014
  ident: B110
  article-title: Evaluation of early implementations of antibiotic stewardship program initiatives in nine Dutch hospitals
  publication-title: Antimicrob. Resist. Infect. Control
  doi: 10.1186/2047-2994-3-33
– volume: 51
  start-page: 45
  year: 2005
  ident: B93
  article-title: Assessment of pharmacokinetic–pharmacodynamic target attainment of gemifloxacin against Streptococcus pneumoniae
  publication-title: Diagn. Microbiol. Infect. Dis.
  doi: 10.1016/j.diagmicrobio.2004.08.019
– volume: 9
  start-page: 65
  year: 2020
  ident: B94
  article-title: Strategies to combat multidrug-resistant and persistent infectious diseases
  publication-title: Antibiotics
  doi: 10.3390/antibiotics9020065
– volume: 22
  start-page: 467
  ident: B14
  article-title: Therapeutic drug monitoring of prolonged infusion aztreonam for multi-drug resistant Pseudomonas aeruginosa: A case report
  publication-title: J. Pediatr. Pharmacol. Ther.
  doi: 10.5863/1551-6776-22.6.467
– volume: 47
  start-page: 999
  year: 2013
  ident: B56
  article-title: Standard versus prolonged doripenem infusion for treatment of gram-negative infections
  publication-title: Ann. Pharmacother.
  doi: 10.1345/aph.1S032
– volume: 14
  start-page: R51
  year: 2010
  ident: B12
  article-title: Prospective monitoring of cefepime in intensive care unit adult patients
  publication-title: Crit. Care
  doi: 10.1186/cc8941
– volume: 19
  start-page: 1
  year: 2019
  ident: B111
  article-title: Methicillin-resistant Staphylococcus aureus (MRSA) in East Africa: Red alert or red herring?
  publication-title: BMC Infect. Dis.
  doi: 10.1186/s12879-019-4245-3
– volume: 69
  start-page: 2797
  year: 2014
  ident: B10
  article-title: Population pharmacokinetics and dosing simulations of cefuroxime in critically ill patients: Non-standard dosing approaches are required to achieve therapeutic exposures
  publication-title: J. Antimicrob. Chemother.
  doi: 10.1093/jac/dku195
– volume: 11
  start-page: e0149623
  year: 2016
  ident: B62
  article-title: Perceptions and practices of community pharmacists towards antimicrobial stewardship in the state of selangor, Malaysia
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0149623
– volume: 65
  start-page: 2499
  year: 2005
  ident: B61
  article-title: Continuous versus intermittent intravenous administration of antibacterials with time-dependent action: A systematic review of pharmacokinetic and pharmacodynamic parameters
  publication-title: Drugs
  doi: 10.2165/00003495-200565170-00006
– volume: 3
  start-page: 25
  year: 2010
  ident: B11
  article-title: Prevention strategies for antimicrobial resistance: A systematic review of the literature
  publication-title: Infect. Drug Resist.
  doi: 10.2147/idr.s10018
– volume: 45
  start-page: 2436
  year: 2001
  ident: B45
  article-title: Pharmacokinetic and pharmacodynamic parameters for antimicrobial effects of cefotaxime and amoxicillin in an in vitro kinetic model
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.45.9.2436-2440.2001
– volume: 10
  start-page: 1454
  ident: B53
  article-title: Dose optimization of colistin: A systematic review
  publication-title: Antibiotics
  doi: 10.3390/antibiotics10121454
– volume: 21
  start-page: 886
  ident: B104
  article-title: Optimization of dosing regimens and dosing in special populations
  publication-title: Clin. Microbiol. Infect.
  doi: 10.1016/j.cmi.2015.05.002
– volume: 59
  start-page: 7027
  year: 2015
  ident: B27
  article-title: Augmented renal clearance implies a need for increased amoxicillin-clavulanic acid dosing in critically ill children
  publication-title: Antimicrob. Agents Chemother.Antimicrobial Agents Chemother.
  doi: 10.1128/aac.01368-15
– start-page: 1807
  volume-title: A Systematic Review of Vancomycin Dosing in Patients with Hematologic Malignancies or Neutropenia
  year: 2020
  ident: B54
– volume: 19
  start-page: 253
  year: 2018
  ident: B107
  article-title: Abstract PCCLB-32: Optimal dosing of meropenem in critically ill asian children receiving continuous renal replacement therapy using population pharmacokinetics
  publication-title: Pediatr. Crit. Care Med.
  doi: 10.1097/01.pcc.0000538117.18545.8d
– volume: 11
  start-page: 521933
  year: 2020
  ident: B25
  article-title: Dose rationale for amoxicillin in neonatal sepsis when referral is not possible
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2020.521933
– volume: 27
  start-page: 615
  year: 2016
  ident: B65
  article-title: Optimizing antimicrobial pharmacodynamics: A guide for your stewardship program
  publication-title: Rev. Medica Clin. Las Condes
  doi: 10.1016/j.rmclc.2016.08.001
– volume: 38
  start-page: 1817
  year: 2015
  ident: B115
  article-title: Pharmacokinetics of prophylactic ampicillin-sulbactam and dosing optimization in patients undergoing cardiovascular surgery with cardiopulmonary bypass
  publication-title: Biol. Pharm. Bull.
  doi: 10.1248/bpb.b15-00334
– volume: 13
  start-page: 118
  year: 2020
  ident: B5
  article-title: Community pharmacists as antibiotic stewards: A qualitative study exploring the current status of antibiotic stewardship program in bahawalpur, Pakistan.
  publication-title: J. Infect. Public Health
  doi: 10.1016/j.jiph.2019.07.003
– volume: 70
  start-page: 2369
  ident: B103
  article-title: Can therapeutic drug monitoring optimize exposure to piperacillin in febrile neutropenic patients with haematological malignancies? A randomized controlled trial
  publication-title: J. Antimicrob. Chemother.
  doi: 10.1093/jac/dkv123
– volume: 74
  start-page: 1342
  year: 2019
  ident: B19
  article-title: Pharmacokinetics of cefazolin delivery via the cardiopulmonary bypass circuit priming solution in infants and children
  publication-title: J. Antimicrob. Chemother.
  doi: 10.1093/jac/dky574
– volume: 37
  start-page: 632
  year: 2011
  ident: B23
  article-title: Optimization of meropenem dosage in the critically ill population based on renal function
  publication-title: Intensive Care Med.
  doi: 10.1007/s00134-010-2105-0
– volume: 6
  start-page: 103
  year: 2017
  ident: B67
  article-title: Clinical impact of an antibiotic stewardship program at a children's hospital.
  publication-title: Infect. Dis. Ther.
  doi: 10.1007/s40121-016-0139-5
– volume: 54
  start-page: 1111
  year: 2010
  ident: B24
  article-title: Clinical pharmacodynamics of cefepime in patients infected with Pseudomonas aeruginosa
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.01183-09
– volume: 7
  start-page: 1207
  year: 2013
  ident: B109
  article-title: The beta lactam antibiotics as an empirical therapy in a developing country: An update on their current status and recommendations to counter the resistance against them
  publication-title: J. Clin. Diagn. Res.
  doi: 10.7860/JCDR/2013/5239.3052
– volume: 19
  start-page: 261
  year: 2002
  ident: B4
  article-title: Animal model pharmacokinetics and pharmacodynamics: A critical review
  publication-title: Int. J. Antimicrob. Agents
  doi: 10.1016/s0924-8579(02)00022-5
– volume: 38
  start-page: 1255
  year: 2019
  ident: B48
  article-title: Target attainment of cefotaxime in critically ill children with meningococcal septic shock as a model for cefotaxime dosing in severe pediatric sepsis
  publication-title: Eur. J. Clin. Microbiol. Infect. Dis.
  doi: 10.1007/s10096-019-03535-w
– volume: 38
  start-page: 462
  year: 2013
  ident: B102
  article-title: Evaluating the appropriate use of piperacillin/tazobactam in a community health system: A retrospective chart review
  publication-title: P Throughput
– volume: 56
  start-page: 236
  year: 2013
  ident: B34
  article-title: Continuous infusion of beta-lactam antibiotics in severe sepsis: A multicenter double-blind, randomized controlled trial.
  publication-title: Clin. Infect. Dis.
  doi: 10.1093/cid/cis856
– volume: 48
  start-page: 1713
  year: 2004
  ident: B85
  article-title: Use of Monte Carlo simulations to select therapeutic doses and provisional breakpoints of BAL9141
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.48.5.1713-1718.2004
– volume: 9
  start-page: 676
  year: 2020
  ident: B2
  article-title: Some suggestions from PK/PD principles to contain resistance in the clinical setting—focus on ICU patients and gram-negative strains
  publication-title: Antibiotics
  doi: 10.3390/antibiotics9100676
– volume: 33
  start-page: 464
  year: 2009
  ident: B72
  article-title: Clinical cure of ventilator-associated pneumonia treated with piperacillin/tazobactam administered by continuous or intermittent infusion
  publication-title: Int. J. Antimicrob. Agents
  doi: 10.1016/j.ijantimicag.2008.10.025
– volume: 72
  start-page: dkw496
  year: 2016
  ident: B26
  article-title: Population pharmacokinetics of cefazolin before, during and after cardiopulmonary bypass to optimize dosing regimens for children undergoing cardiac surgery
  publication-title: J. Antimicrob. Chemother.
  doi: 10.1093/jac/dkw496
– volume: 19
  start-page: 291
  year: 2002
  ident: B78
  article-title: Developments in PK/PD: Optimising efficacy and prevention of resistance. A critical review of PK/PD in in vitro models
  publication-title: Int. J. Antimicrob. Agents
  doi: 10.1016/s0924-8579(02)00027-4
– volume: 10
  start-page: 280
  year: 2021
  ident: B3
  article-title: Antimicrobial stewardship program implementation in a Saudi medical city: An exploratory case study
  publication-title: Antibiotics
  doi: 10.3390/antibiotics10030280
– volume: 60
  start-page: 6619
  year: 2016
  ident: B75
  article-title: Population pharmacokinetics and dosing regimen optimization of meropenem in cerebrospinal fluid and plasma in patients with meningitis after neurosurgery
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.00997-16
– volume: 31
  start-page: 767
  year: 2011
  ident: B118
  article-title: The retrospective cohort of extended-infusion piperacillin-tazobactam (RECEIPT) study: A multicenter study
  publication-title: Pharmacotherapy
  doi: 10.1592/phco.31.8.767
– volume: 22
  start-page: 276
  ident: B16
  article-title: Population pharmacokinetics and pharmacodynamic target attainment of meropenem in critically ill young children
  publication-title: J. Pediatr. Pharmacol. Ther.
  doi: 10.5863/1551-6776-22.4.276
– volume: 66
  start-page: 1223
  year: 2011
  ident: B58
  article-title: Impact of antimicrobial stewardship in critical care: A systematic review
  publication-title: J. Antimicrob. Chemother.
  doi: 10.1093/jac/dkr137
– volume: 33
  start-page: 168
  year: 2014
  ident: B20
  article-title: Population pharmacokinetics of piperacillin/tazobactam in critically ill young children.
  publication-title: Pediatr. Infect. Dis. J.
  doi: 10.1097/INF.0b013e3182a743c7
– volume: 35
  start-page: 156
  year: 2010
  ident: B100
  article-title: First-dose and steady-state population pharmacokinetics and pharmacodynamics of piperacillin by continuous or intermittent dosing in critically ill patients with sepsis
  publication-title: Int. J. Antimicrob. Agents
  doi: 10.1016/j.ijantimicag.2009.10.008
– volume: 76
  start-page: 1547
  year: 2020
  ident: B63
  article-title: Population pharmacokinetics and dose optimization of ceftriaxone for children with community-acquired pneumonia
  publication-title: Eur. J. Clin. Pharmacol.
  doi: 10.1007/s00228-020-02939-4
– volume: 49
  start-page: 121
  year: 2002
  ident: B9
  article-title: Pharmacokinetics of ceftazidime in serum and peritoneal exudate during continuous versus intermittent administration to patients with severe intra-abdominal infections
  publication-title: J. Antimicrob. Chemother.
  doi: 10.1093/jac/49.1.121
– volume: 10
  start-page: 4
  year: 2020
  ident: B64
  article-title: Clinical pharmacokinetics of 3-h extended infusion of meropenem in adult patients with severe sepsis and septic shock: Implications for empirical therapy against gram-negative bacteria
  publication-title: Ann. Intensive Care
  doi: 10.1186/s13613-019-0622-8
– volume: 50
  start-page: 2563
  year: 2006
  ident: B40
  article-title: Prospective determination of plasma imipenem concentrations in critically ill children
  publication-title: Antimicrob. Agents Chemother.Antimicrobial Agents Chemother.
  doi: 10.1128/AAC.01149-05
– volume: 29
  start-page: 2433
  year: 2007
  ident: B73
  article-title: Comparison of clinical cure rates in adults with ventilator-associated pneumonia treated with intravenous ceftazidime administered by continuous or intermittent infusion: A retrospective, nonrandomized, open-label, historical chart review
  publication-title: Clin. Ther.
  doi: 10.1016/j.clinthera.2007.11.003
SSID ssj0000399364
Score 2.3357093
SecondaryResourceType review_article
Snippet Background: β-lactams remain the cornerstone of the empirical therapy to treat various bacterial infections. This systematic review aimed to analyze the data...
β-lactams remain the cornerstone of the empirical therapy to treat various bacterial infections. This systematic review aimed to analyze the data describing...
Background: β-lactams remain the cornerstone of the empirical therapy to treat various bacterial infections. This systematic review aimed to analyze the data...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 964005
SubjectTerms beta-Lactams
carbapenems
cephalosporins
dose optimization
penicillins
Pharmacology
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Lat0wEBUlq25K33VfqFCyKHFjy3rY3aWPEAotWSSQrszIHpELiX2pbxb5rXxIvqkzlu-rlHbTrSVhMTPSzEEzZ4R4y09lqINJDViT6oA-9aAwtQFLIJVrpbga-dt3e3Sqv56Zs41WX5wTFumBo-D2s0K3LmDwLQX2oQ0-eF-1BsoGIaBu-fYln7cBpsY7mP2u1fEZk1BYtR_m58D8n0q9rywZrtlyRCNf_5-CzN9zJTecz-F9cW-KGuVB3O0DcQe7h2L3ONJOX-_Jk3UV1bAnd-XxmpD6-pH48bkfUPZ0OVxOVZeyD_L2Jr2AZgGXgyTpzvys59Vy1sn5sn0Hj7RypOgYPsgDuaZ9lrHk5bE4Pfxy8ukonVoqpI22ZpGCMahsE7AoMKtc43JTKl16k7cQcnQBsswHCuGcN8EVDVCAQQAuhBwsQamseCJ2ur7DZ0IS9gFCazSVIBVmFgANRWdV1ngoSMCJyJbyrZuJb5zbXlzUhDtYJfWokppVUkeVJOLdask8km38bfJHVtpqIvNkjx_IeurJeup_WU8i3ixVXtO54scS6LC_GmrlVKFLZpNLxNNoAqtfkdPn1EyXCLdlHFt72R7pZucjd3dFMqID8Px_bP6FuMvy4OwVlb8UO4ufV_iKQqSFfz2ehl83qRZE
  priority: 102
  providerName: Directory of Open Access Journals
Title Dose optimization of β-lactams antibiotics in pediatrics and adults: A systematic review
URI https://www.ncbi.nlm.nih.gov/pubmed/36210807
https://www.proquest.com/docview/2723484656
https://pubmed.ncbi.nlm.nih.gov/PMC9532942
https://doaj.org/article/034d7fefbd164fdfbfbb9d5a8ceafe4d
Volume 13
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBYhvfRS-q77CCqUHEqc2rIedqGU9BFCISWHLKQnM7KlZGFjb9cb6P6t_pD-ps7I3t1uWXrq1ZKwmU-jmc-SvmHsFW2VOelVrECrWHpnYwvCxdq7HBByKQTdRj79qk9G8suFuthhy_JWgwG7rdSO6kmNZpPDH98X79Hh3xHjxHj7xk-vgKQ9hTgstAyKprcwMBkqaHA6ZPthYaZgrGW_t7l95EZ0CiL-2zLPvw9Q_hGRju-yO0MqyY967O-xHdfcZ_tnvRb14oCfr69WdQd8n5-tVaoXD9i3T23neIsrxvVwFZO3nv_6GU-gmsN1x9HkYztuaTQfN3y6rOlBLTUPuh3dW37E11rQvL8H85CNjj-ffzyJhzoLcSW1mseglBO68i7LXFKYyqQqFzK3Kq3Bp854SBLrMa8zVnmTVYBZB7I671PQyK-S7BHbbdrGPWEcCREghcOuyLNcogGcwpStSCoLGRo4YsnSvmU1iJBTLYxJiWSEICkDJCVBUvaQROz1asi0V-D4V-cPBNqqI4lnhwft7LIcfLFMMlkb77ytkSv62ltvbVEryCsH3sk6Yi-XkJfobLSDAo1rb7pSGJHJnCTmIva4nwKrV2EmQOc1TcTMxuTY-JbNlmZ8FQS9C7QResXT__Hxz9htsgcdaRHpc7Y7n924F5g3ze1e-N-wF3ziN_tLHc8
linkProvider Scholars Portal
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Dose+optimization+of+%CE%B2-lactams+antibiotics+in+pediatrics+and+adults%3A+A+systematic+review&rft.jtitle=Frontiers+in+pharmacology&rft.au=Abdul+Haseeb&rft.au=Hani+Saleh+Faidah&rft.au=Saleh+Alghamdi&rft.au=Amal+F.+Alotaibi&rft.date=2022-09-21&rft.pub=Frontiers+Media+S.A&rft.eissn=1663-9812&rft.volume=13&rft_id=info:doi/10.3389%2Ffphar.2022.964005&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_034d7fefbd164fdfbfbb9d5a8ceafe4d
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1663-9812&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1663-9812&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1663-9812&client=summon