Role of Microbiota in Viral Infections and Pathological Progression

Viral infections are influenced by various microorganisms in the environment surrounding the target tissue, and the correlation between the type and balance of commensal microbiota is the key to establishment of the infection and pathogenicity. Some commensal microorganisms are known to resist or pr...

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Published inViruses Vol. 14; no. 5; p. 950
Main Authors Mizutani, Taketoshi, Ishizaka, Aya, Koga, Michiko, Tsutsumi, Takeya, Yotsuyanagi, Hiroshi
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.05.2022
MDPI
Subjects
Coronaviruses
Dysbacteriosis
Dysbiosis
Gastrointestinal Microbiome
Human papillomavirus
Humans
infectious disease
microbiome
Microbiota
Microorganisms
Pathogenicity
Review
SARS-CoV-2
Viral diseases
Viral infections
virome
Virus Diseases
Viruses
COVID-19
microbiota
virome
SARS-CoV-2
HIV
hepatitis virus
infectious disease
microbiome
HPV
dysbiosis
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Abstract Viral infections are influenced by various microorganisms in the environment surrounding the target tissue, and the correlation between the type and balance of commensal microbiota is the key to establishment of the infection and pathogenicity. Some commensal microorganisms are known to resist or promote viral infection, while others are involved in pathogenicity. It is also becoming evident that the profile of the commensal microbiota under normal conditions influences the progression of viral diseases. Thus, to understand the pathogenesis underlying viral infections, it is important to elucidate the interactions among viruses, target tissues, and the surrounding environment, including the commensal microbiota, which should have different relationships with each virus. In this review, we outline the role of microorganisms in viral infections. Particularly, we focus on gaining an in-depth understanding of the correlations among viral infections, target tissues, and the surrounding environment, including the commensal microbiota and the gut virome, and discussing the impact of changes in the microbiota (dysbiosis) on the pathological progression of viral infections.
AbstractList Viral infections are influenced by various microorganisms in the environment surrounding the target tissue, and the correlation between the type and balance of commensal microbiota is the key to establishment of the infection and pathogenicity. Some commensal microorganisms are known to resist or promote viral infection, while others are involved in pathogenicity. It is also becoming evident that the profile of the commensal microbiota under normal conditions influences the progression of viral diseases. Thus, to understand the pathogenesis underlying viral infections, it is important to elucidate the interactions among viruses, target tissues, and the surrounding environment, including the commensal microbiota, which should have different relationships with each virus. In this review, we outline the role of microorganisms in viral infections. Particularly, we focus on gaining an in-depth understanding of the correlations among viral infections, target tissues, and the surrounding environment, including the commensal microbiota and the gut virome, and discussing the impact of changes in the microbiota (dysbiosis) on the pathological progression of viral infections.Viral infections are influenced by various microorganisms in the environment surrounding the target tissue, and the correlation between the type and balance of commensal microbiota is the key to establishment of the infection and pathogenicity. Some commensal microorganisms are known to resist or promote viral infection, while others are involved in pathogenicity. It is also becoming evident that the profile of the commensal microbiota under normal conditions influences the progression of viral diseases. Thus, to understand the pathogenesis underlying viral infections, it is important to elucidate the interactions among viruses, target tissues, and the surrounding environment, including the commensal microbiota, which should have different relationships with each virus. In this review, we outline the role of microorganisms in viral infections. Particularly, we focus on gaining an in-depth understanding of the correlations among viral infections, target tissues, and the surrounding environment, including the commensal microbiota and the gut virome, and discussing the impact of changes in the microbiota (dysbiosis) on the pathological progression of viral infections.
Viral infections are influenced by various microorganisms in the environment surrounding the target tissue, and the correlation between the type and balance of commensal microbiota is the key to establishment of the infection and pathogenicity. Some commensal microorganisms are known to resist or promote viral infection, while others are involved in pathogenicity. It is also becoming evident that the profile of the commensal microbiota under normal conditions influences the progression of viral diseases. Thus, to understand the pathogenesis underlying viral infections, it is important to elucidate the interactions among viruses, target tissues, and the surrounding environment, including the commensal microbiota, which should have different relationships with each virus. In this review, we outline the role of microorganisms in viral infections. Particularly, we focus on gaining an in-depth understanding of the correlations among viral infections, target tissues, and the surrounding environment, including the commensal microbiota and the gut virome, and discussing the impact of changes in the microbiota (dysbiosis) on the pathological progression of viral infections.
Author Ishizaka, Aya
Koga, Michiko
Tsutsumi, Takeya
Yotsuyanagi, Hiroshi
Mizutani, Taketoshi
AuthorAffiliation 1 Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba 277-8562, Japan
3 Department of Infectious Diseases and Applied Immunology, IMSUT Hospital of Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
2 Division of Infectious Diseases, Advanced Clinical Research Center, the Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan; ishizaka@ims.u-tokyo.ac.jp (A.I.); michiko@ims.u-tokyo.ac.jp (M.K.); tsutsumi@ims.u-tokyo.ac.jp (T.T.); yotsudid@ims.u-tokyo.ac.jp (H.Y.)
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– name: 2 Division of Infectious Diseases, Advanced Clinical Research Center, the Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan; ishizaka@ims.u-tokyo.ac.jp (A.I.); michiko@ims.u-tokyo.ac.jp (M.K.); tsutsumi@ims.u-tokyo.ac.jp (T.T.); yotsudid@ims.u-tokyo.ac.jp (H.Y.)
– name: 3 Department of Infectious Diseases and Applied Immunology, IMSUT Hospital of Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/35632692$$D View this record in MEDLINE/PubMed
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Copyright_xml – notice: 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Issue 5
Keywords COVID-19
microbiota
virome
SARS-CoV-2
HIV
hepatitis virus
infectious disease
microbiome
HPV
dysbiosis
Language English
License https://creativecommons.org/licenses/by/4.0
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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SubjectTerms Coronaviruses
Dysbacteriosis
Dysbiosis
Gastrointestinal Microbiome
Human papillomavirus
Humans
infectious disease
microbiome
Microbiota
Microorganisms
Pathogenicity
Review
SARS-CoV-2
Viral diseases
Viral infections
virome
Virus Diseases
Viruses
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Title Role of Microbiota in Viral Infections and Pathological Progression
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