The Comprehensive Analysis Identified an Autophagy Signature for the Prognosis and the Immunotherapy Efficiency Prediction in Lung Adenocarcinoma

• Published in: Frontiers in immunology Vol. 13; p. 749241
• Main Authors: Li, Xizhe, Dai, Ziyu, Wu, Xianning, Zhang, Nan, Zhang, Hao, Wang, Zeyu, Zhang, Xun, Liang, Xisong, Luo, Peng, Zhang, Jian, Liu, Zaoqu, Zhou, Yanwu, Cheng, Quan, Chang, Ruimin
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 22.04.2022
• Subjects: Adenocarcinoma of Lung - genetics; Adenocarcinoma of Lung - therapy; autophagy; Autophagy - genetics; Biomarkers, Tumor - genetics; DRAM1; Gene Expression Profiling; gene signature; Humans; immune checkpoint therapy; Immunology; Immunotherapy; lung adenocarcinoma; Lung Neoplasms - diagnosis; Lung Neoplasms - genetics; Lung Neoplasms - therapy; Prognosis; Programmed Cell Death 1 Receptor - genetics; TCGA; DRAM1; autophagy; gene signature; immune checkpoint therapy; TCGA; lung adenocarcinoma

Lung adenocarcinoma (LUAD) is a fatal malignancy in the world. Growing evidence demonstrated that autophagy-related genes regulated the immune cell infiltration and correlated with the prognosis of LUAD. However, the autophagy-based signature that can predict the prognosis and the efficiency of chec...