Functional Characterization of Glycoprotein Nonmetastatic Melanoma Protein B in Scleroderma Fibrosis

• Published in: Frontiers in immunology Vol. 13; p. 814533
• Main Authors: Palisoc, Pamela J., Vaikutis, Leah, Gurrea-Rubio, Mikel, Model, Ellen N., O’mara, Morgan M., Ory, Sarah, Vichaikul, Sirapa, Khanna, Dinesh, Tsou, Pei-Suen, Sawalha, Amr H.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 24.02.2022
• Subjects: autoimmunity; dermal fibroblasts; Fibrosis; Glycoproteins; GPNMB; Humans; Immunology; Melanoma; Membrane Glycoproteins - genetics; Receptors, Fc; scleroderma; Scleroderma, Diffuse; Scleroderma, Localized; Scleroderma, Systemic - pathology; dermal fibroblasts; fibrosis; GPNMB; autoimmunity; scleroderma
• ISSN: 1664-3224; 1664-3224
• DOI: 10.3389/fimmu.2022.814533

Glycoprotein nonmetastatic melanoma protein B (GPNMB) is involved in various cell functions such as cell adhesion, migration, proliferation, and differentiation. In this study, we set forth to determine the role of GPNMB in systemic sclerosis (SSc) fibroblasts. Dermal fibroblasts were isolated from...