In Obese Patients With Type 2 Diabetes, Mast Cells in Omental Adipose Tissue Decrease the Surface Expression of CD45, CD117, CD203c, and FcϵRI

• Published in: Frontiers in endocrinology (Lausanne) Vol. 13; p. 818388
• Main Authors: Lopez-Perez, David, Redruello-Romero, Anaïs, Garcia-Rubio, Jesús, Arana, Carlos, Garcia-Escudero, Luis A, Tamayo, Francisco, Salmeron, Javier, Galvez, Julio, Leon, Josefa, Carazo, Ángel
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 15.03.2022
• Subjects: adipose tissue; Adipose Tissue - metabolism; bariatric surgery; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - metabolism; Endocrinology; flow cytometry; Humans; Leukocyte Common Antigens; mast cell; Mast Cells - physiology; obesity; Obesity, Morbid - complications; Phosphoric Diester Hydrolases; Proto-Oncogene Proteins c-kit; Pyrophosphatases; Receptors, IgE - metabolism; type 2 diabetes; adipose tissue; mast cell; flow cytometry; bariatric surgery; type 2 diabetes; obesity

The paradigm of mast cells in type 2 diabetes is changing. Although they were first considered deleterious inflammatory cells, now they seem to be important players driving adipose tissue homeostasis. Here we have employed a flow cytometry-based approach for measuring the surface expression of 4 pro...