Poor Sleep Quality is Linked to Elevated Extracellular Vesicle-Associated Inflammatory Cytokines in Warfighters With Chronic Mild Traumatic Brain Injuries

• Published in: Frontiers in pharmacology Vol. 12; p. 762077
• Main Authors: Gottshall, Jackie L, Guedes, Vivian A, Pucci, Josephine U, Brooks, Daniel, Watson, Nora, Sheth, Phorum, Gabriel, Ainslee, Mithani, Sara, Leete, Jacqueline J, Lai, Chen, Qu, Bao-Xi, Devoto, Christina, Gill, Jessica M, Kenney, Kimbra, Werner, J Kent
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 27.01.2022
• Subjects: cytokines; extracellular vesicles; IL-6; inflammation; Pharmacology; sleep; traumatic brain injury; sleep; extracellular vesicles; inflammation; tNF-alpha; traumatic brain injury; cytokines; IL-10; IL-6

Elevations of inflammatory cytokine levels occur immediately after mild traumatic brain injury (mTBI) and can persist for years. These elevations have been associated with neuropsychological outcomes, including depression and PTSD symptoms. Sleep disorders, another common sequelae of mTBI, are indep...