Inhibition of SARS-CoV-2 by Targeting Conserved Viral RNA Structures and Sequences

• Published in: Frontiers in chemistry Vol. 9; p. 802766
• Main Authors: Hegde, Shalakha, Tang, Zhichao, Zhao, Junxing, Wang, Jingxin
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 23.12.2021
• Subjects: antisense oligonucleotide; antiviral; Chemistry; RNA-targeting; SARS-CoV-2; small molecule; untranslated region; SARS-CoV-2; small molecule; RIBOTAC; antisense oligonucleotide; antiviral; programmed frameshift; untranslated region; RNA-targeting

The ongoing COVID-19/Severe Acute Respiratory Syndrome CoV-2 (SARS-CoV-2) pandemic has become a significant threat to public health and has hugely impacted societies globally. Targeting conserved SARS-CoV-2 RNA structures and sequences essential for viral genome translation is a novel approach to in...