Vestibular prepulse inhibition of the human blink reflex

• Published in: Clinical neurophysiology Vol. 167; pp. 1 - 11
• Main Authors: Ciocca, Matteo, Hosli, Sarah, Hadi, Zaeem, Mahmud, Mohammad, Tai, Yen F, Seemungal, Barry M
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2024
• Subjects: Adult; Aged; Blink reflex; Blinking - physiology; Electric Stimulation - methods; Female; Galvanic vestibular stimulation; Humans; Male; Middle Aged; Neurology; Pedunculopontine nucleus; Prepulse inhibition; Prepulse Inhibition - physiology; Reflex, Vestibulo-Ocular - physiology; Vestibular system; Vestibule, Labyrinth - physiology; Young Adult; Vestibular system; Blink reflex; Galvanic vestibular stimulation; Pedunculopontine nucleus; Prepulse inhibition

•This is the first report of a vestibular prepulse inhibition of the blink reflex.•A vestibular prepulse inhibits the R2 and R2c area in healthy subjects but not in patients with bilateral peripheral vestibular failure.•Vestibular PPI is a potential neurophysiological marker of vestibulo-motor integ...