Allosteric Inhibition of a Zinc-Sensing Transcriptional Repressor: Insights into the Arsenic Repressor (ArsR) Family - Campanello, Gregory C.; Ma, Zhen; Grossoehme, Nicholas E.; Guerra, Alfredo J.; Ward, Brian P.; DiMarchi, Richard D.; Ye, Yuzhen; Dann, Charles E.; Giedroc, David P. (Journal of molecular biology, 2013)
Keywords: Allosteric Regulation; allostery; Amino Acid Substitution; ArsR; Bacterial Proteins; Bacterial Proteins - chemistry; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Binding Sites; Binding Sites - genetics; Binding, Competitive; chemistry; Crystallography, X-Ray; DNA; DNA-Binding Proteins; DNA-Binding Proteins - chemistry; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; energy; evolution; genetics; Hydrogen Bonding; Kinetics; metabolism; metal homeostasis; metal ions; Models, Molecular; mutants; Mutation; Protein Binding; Protein Multimerization; Protein Structure, Secondary; Protein Structure, Tertiary; proteins; Repressor Proteins; Repressor Proteins - chemistry; Repressor Proteins - genetics; Repressor Proteins - metabolism; Staphylococcus aureus; Staphylococcus aureus - genetics; Staphylococcus aureus - metabolism; statistical coupling analysis; Thermodynamics; transcription (genetics); Transcription, Genetic; zinc; Zinc - chemistry; Zinc - metabolism; zinc sensor; SCA; TROSY; statistical coupling analysis; zinc sensor; ITC; metal homeostasis; HSQC; TCEP; allostery; ArsR